Discover and read the best of Twitter Threads about #fibrosis
Most recents (15)
¿Cómo debemos sospechar #aortitis y cuándo sospecharla?
Dr. Javier Loricera García
#25TenTopicsBCN #TenTopics
Dr. Javier Loricera García
#25TenTopicsBCN #TenTopics
¿Cómo debemos sospechar #aortitis y cuándo sospecharla? #Aortitis #infecciosa
#25TenTopicsBCN #TenTopics
#25TenTopicsBCN #TenTopics
Interstitial lung disease in rheumatic diseases
Dr. Vanessa Smith
#ILD #autoimmune 🫁🚨🩻
#25TenTopicsBCN #TenTopics
1⃣ Need for a multidisciplinary team
2⃣ Awareness in peers
Dr. Vanessa Smith
#ILD #autoimmune 🫁🚨🩻
#25TenTopicsBCN #TenTopics
1⃣ Need for a multidisciplinary team
2⃣ Awareness in peers
1) Welcome to a new #accredited #tweetorial on #hypertrophic #cardiomyopathy #HCM. Our expert author is Ahmad Masri MD @MasriAhmadMD of @OHSUCardio where he leads the Hypertrophic Cardiomyopathy Ctr. See a previous program from him, on #Fabry disease, at cardiometabolic-ce.com/cardiorenal-fa….
2a) This program is intended for #healthcare providers and is supported by an educational grant from Bristol-Myers Squibb. Statement of accreditation and faculty disclosures at cardiometabolic-ce.com/disclosures/. FOLLOW US for the most timely expert education in #cardiometabolic care!
2b) #Physicians #Nurses #PhysicianAssociates #NursePractitioners #Pharmacists earn a full 1⃣ hour of 🆓CE/#CME credit from following this 🧵. For educational purposes, Twitter still works!! 😁
SEMINAL ARTICLE re: #ICD11 Chapter 08 - Diseases of the #NervousSystem 🧠
Study Title: The #leptomeninges as a critical organ for normal #CNS development and function: first patient and public involved systematic review of #arachnoiditis (chronic #meningitis). @PLOSONE
Study Title: The #leptomeninges as a critical organ for normal #CNS development and function: first patient and public involved systematic review of #arachnoiditis (chronic #meningitis). @PLOSONE
LINK: journals.plos.org/plosone/articl… @PLOSONE
Abbreviations:
#CES- #CaudaEquina Syndrome
#DLM – Diseases of the #Leptomeninges
#ESI- #Epidural Steroid Injection
LM - #Leptomeninges
#LMF- #Leptomeningeal #Fibrosis
#NAA- #neuraxialanesthesia
PSR- PRISMA Systematic Review
Abbreviations:
#CES- #CaudaEquina Syndrome
#DLM – Diseases of the #Leptomeninges
#ESI- #Epidural Steroid Injection
LM - #Leptomeninges
#LMF- #Leptomeningeal #Fibrosis
#NAA- #neuraxialanesthesia
PSR- PRISMA Systematic Review
#SAH- #Subarachnoid Hemorrhage
#SAS- #Subarachnoid Space
Key Findings:
1. A varyingly described, and poorly characterized #CNS disease called #arachnoiditis (aka #adhesivearachnoiditis) was exhaustively systematically-reviewed for the first time.
#SAS- #Subarachnoid Space
Key Findings:
1. A varyingly described, and poorly characterized #CNS disease called #arachnoiditis (aka #adhesivearachnoiditis) was exhaustively systematically-reviewed for the first time.
There’s been some questions recently here about the types of #IBD research that @CrohnsColitisFn supports. I want to highlight some of the innovative projects that we are working on to bring us closer to our vision of a future free from #CrohnsDisease & #UlcerativeColitis.
.@CrohnsColitisFn is proud to be a collaborator on over 200 #IBD research projects in the US & around the world that are helping to improve patient quality of life and bring us closer to cures. Here are some examples:
We support the work of researchers at @ut_dallas who developed and are testing a wrist-watch like device that monitors sweat for biomarkers that could indicate an #IBD flare: crohnscolitisfoundation.org/blog/researche…
1) Welcome to our new #accredited #tweetorial on the Pathophysiology of #DKD in #T2D: Traditional Teaching and New Insights. Our expert author is Hans-Joachim Anders, MD, @hjanders_hans from @LMU_Uniklinikum of @LMU_Muenchen
2) This #accredited #tweetorial series on the foundations of #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists. Past programs still eligible for credit can be found at ckd-ce.com. Faculty disclosures & accreditation statement are at ckd-ce.com/disclosures/. FOLLOW US!
📢Personalized medicine in #NAFLD by @DrLoomba
✅Current gaps in #NAFLD:
- Rapid progressors
- non-cirrhotic HCC
😧At risk NASH (F2 beyond)? Try these👇
✅FAST (low PPV) - exclude biopsy
✅MAST (PPV 91-97) - rule-in & treat
✅MEFIB (AUROC 0.9)
#ILC2022 #Livertwitter @EASLedu
✅Current gaps in #NAFLD:
- Rapid progressors
- non-cirrhotic HCC
😧At risk NASH (F2 beyond)? Try these👇
✅FAST (low PPV) - exclude biopsy
✅MAST (PPV 91-97) - rule-in & treat
✅MEFIB (AUROC 0.9)
#ILC2022 #Livertwitter @EASLedu
Personalized medicine in #NAFLD by @DrLoomba
🔥Gut microbiome (AUROC 0.936)
- Detect advanced #fibrosis
- Identify 1st-degree relative with #cirrhosis (ethnically universal)
👉DOI: 10.1016/j.cmet.2020.06.005
- FGF19 treatment response in #NASH
#ILC2022 #LiverTwitter @EASLedu
🔥Gut microbiome (AUROC 0.936)
- Detect advanced #fibrosis
- Identify 1st-degree relative with #cirrhosis (ethnically universal)
👉DOI: 10.1016/j.cmet.2020.06.005
- FGF19 treatment response in #NASH
#ILC2022 #LiverTwitter @EASLedu
Personalized #NASH treatment by @DrLoomba
Choose yr drugs based on🎯
⏩#Fibrosis reversal vs #NASH resolution?
✅Combination = way forward. Why?
⏫Efficacy
⏬Dose ( ?potentially ⏬AE)
#ILC2022 #LiverTwitter @jturnesv @aelsharkawy75 @IanARowe @DharJahnvi @drshafikuchay
Choose yr drugs based on🎯
⏩#Fibrosis reversal vs #NASH resolution?
✅Combination = way forward. Why?
⏫Efficacy
⏬Dose ( ?potentially ⏬AE)
#ILC2022 #LiverTwitter @jturnesv @aelsharkawy75 @IanARowe @DharJahnvi @drshafikuchay
1) Welcome to our new #accredited #tweetorial on the Pathophysiology of #DKD in #T2D: Traditional Teaching and New Insights. Our expert author is Hans-Joachim Anders, MD, @hjanders_hans from @LMU_Uniklinikum of @LMU_Muenchen
2) This #accredited #tweetorial series on the foundations of #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists 🇺🇸🇪🇺🇬🇧🇨🇦. Past programs still eligible for credit are at ckd-ce.com. Faculty disclosures are at ckd-ce.com/disclosures/. FOLLOW US for regular programs by expert faculty!
#1 #Covid19 #Supplement thread for #LongCovid #LongHaul #PostCovid. This may help, if you suffer from #fatigue #brainfog #jointpain #inflammation #weakness #depression #anxiety #SOB #clots #fibrosis #myocarditis #heartattack #stroke #alz #memory frontiersin.org/articles/10.33…
#2 B-COMPLEX/MULTI VITAMIN. Buy a liposomal or other form that increases bio-availability. Take 1 capsule w/Breakfast and Lunch. If you have stomach upset, try sublingual (under tongue) EZ Melt B-Complex in AM & Multi w/iron for Dinner. amazon.com/Liposomal-Meth…
#3 OMEGA 3s. Fish Oil, Krill Oil, Algae Oil are all good sources of Omega 3. Be careful the EPA/DHA ratio. EPA helps with inflammation/DHA helps with cognition. You need both! Opt for a 1:1 or 2:1 ratio of DHA to EPA (2:1 ratio eg. 800 DHA/400EPA) amazon.com/3Care-Concentr…
#COVID19: ACTUALIZACIÓN NOVIEMBRE 2020
Desde la nueva vacuna fase 3 de #Pfizer hasta las #reinfecciones, #secuelas e #inmunidad.
Hoy les hablare sobre lo que nos ha dado al evidencia científica al respecto de estos temas, pero lo haremos con memes de #BobEsponja.
Abro hilo 🧵
Desde la nueva vacuna fase 3 de #Pfizer hasta las #reinfecciones, #secuelas e #inmunidad.
Hoy les hablare sobre lo que nos ha dado al evidencia científica al respecto de estos temas, pero lo haremos con memes de #BobEsponja.
Abro hilo 🧵
De acuerdo a la revista médica #TheLancet, se define como evidencia científica al uso consciente, explícito y juicioso de datos válidos y disponibles procedentes de la investigación científica, con lo que podemos tomar decisiones clínicas.
Algo así como LA CARACOLA MAGICA ✨
Algo así como LA CARACOLA MAGICA ✨
6 THINGS YOU SHOULD KNOW ABOUT HEPATITIS B
1. Affects your liver
2. Extremely infectious
3. Many show no symptoms
4. Vaccine protects you
5. Can be treated
6. You can live a long, productive life with #HepatitisB infection if you treated.
A thread 🧵
{RT for awareness!}
1. Affects your liver
2. Extremely infectious
3. Many show no symptoms
4. Vaccine protects you
5. Can be treated
6. You can live a long, productive life with #HepatitisB infection if you treated.
A thread 🧵
{RT for awareness!}
First, #HepatitisB, like other viral hepatitis, loves the #liver.
Once infected, the virus goes straight to your liver, multiplies alarmingly, & tries to evade immune attacks.
In some, immune system clears the virus so they recover. In others, no, so they remain infected.
Once infected, the virus goes straight to your liver, multiplies alarmingly, & tries to evade immune attacks.
In some, immune system clears the virus so they recover. In others, no, so they remain infected.
People who remain infected with #hepatitisB over a long period of time may develop liver issues.
Such liver problems may include #fibrosis, #cirrhosis, #livercancer, & #liverfailure.
If not detected & treated on time, the person may die of these complications.
Such liver problems may include #fibrosis, #cirrhosis, #livercancer, & #liverfailure.
If not detected & treated on time, the person may die of these complications.
Cool #Senescence paper #2, in @JCI_insight: insight.jci.org/articles/view/….
@marissa_schafer, Xu Zhang, @NKLeBRASSEUR & team dive into the details of SASP, the Senescence Associated Secretory Phenotype first discovered in the Campisi lab @BuckInstitute.
@marissa_schafer, Xu Zhang, @NKLeBRASSEUR & team dive into the details of SASP, the Senescence Associated Secretory Phenotype first discovered in the Campisi lab @BuckInstitute.
SASP is a prime suspect for how #Senescent cells cause #Inflammation, #Cancer and #Fibrosis. But SASP is a mix of many secreted proteins, so the @MayoClinic looked closely at 24 factors.
1st, they show which factors are secreted by different cell types (in culture).
1st, they show which factors are secreted by different cell types (in culture).
Next, and more exciting, they measured which SASP factors increase with age in human blood. #ChronicInflammation is an important mechanism of aging, but really defining #ChronicInflammation is hard and often not even attempted. So this detailed analysis is great.
Time to catch up on some #Senescence papers, starting with beautiful work by @corina_amor_MD, Judith Freucht & @JosefLeibold. They used #CART #CellTherapy to clear #Senescent cells, and you'll never guess what happened next! nature.com/articles/s4158…
Just kidding, you guessed it: disease model mice got better. Props to the authors for A) inducing #Senescence in 3 different ways, B) using 2 models of #NASH/liver #Fibrosis, and C) validating their senescence observations in human samples of #Cancer and #Atherosclerosis.
The linchpin of the paper was identifying a specific membrane marker on #Senescent cells, uPAR. They used bulk #Transcriptomics to identify candidates, then narrowed down with #Proteomic data. Go #Omics!
They didn't explore whether uPAR is causative for the #Senescent phenotype.
They didn't explore whether uPAR is causative for the #Senescent phenotype.
1/13
Primer ensayo clínico fase 3 con resultados positivos en pacientes con esteatohepatitis no alcohólica (#NASH) ow.ly/28oF50xuGPY en @TheLancet. El ácido #obeticólico reduce el grado de fibrosis hepática en pacientes con NASH y fibrosis avanzada. ¿Es lo que esperábamos?
Primer ensayo clínico fase 3 con resultados positivos en pacientes con esteatohepatitis no alcohólica (#NASH) ow.ly/28oF50xuGPY en @TheLancet. El ácido #obeticólico reduce el grado de fibrosis hepática en pacientes con NASH y fibrosis avanzada. ¿Es lo que esperábamos?
@TheLancet 3/
Hay que valorar los resultados con cautela, se trata de un análisis interino a los 18 meses de tratamiento en pacientes con #NASH y fibrosis F2-F3. Incluye "solo" 931 pacientes con 2 biopsias de los 1968 aleatorizados. Los objetivos coprimarios son histológicos, y no clínicos
Hay que valorar los resultados con cautela, se trata de un análisis interino a los 18 meses de tratamiento en pacientes con #NASH y fibrosis F2-F3. Incluye "solo" 931 pacientes con 2 biopsias de los 1968 aleatorizados. Los objetivos coprimarios son histológicos, y no clínicos
IL11 signaling in fibroblasts in IPF biorxiv.org/content/10.110…. Follow up on a recent report on IL11 as a therapeutic target for IPF (stm.sciencemag.org/content/11/511…) - the original had good human data and some nice mouse models. @stuartacook1 #Immunology #Fibrosis
This preprint dissects out the signaling with a floxed IL11RA1, conditionally deleted in fibroblasts. This drives basically the entire phenotype, and there are striking reductions in fibrosis in the fibroblast-KO mice. There’s also substantially lower inflammation.
I’d like to see some earlier timepoints looking at the inflammation, since the earliest immunophenotyping looks like day 14 - after major damage has already started. It’d also be interesting to try inducible deletion of IL11RA1 after initial bleomycin administration.
