Discover and read the best of Twitter Threads about #Senescence
Most recents (7)
1/5 Fascinating work from Jae-Hyun Yang and colleagues on #mammalian #aging, published in Cell...
An abstract thread 🧵...
"All living things experience an increase in #entropy, manifested as a loss of #genetic and #epigenetic information."
cell.com/cell/fulltext/…
An abstract thread 🧵...
"All living things experience an increase in #entropy, manifested as a loss of #genetic and #epigenetic information."
cell.com/cell/fulltext/…
2/5 "In #yeast, #epigenetic information is lost over time due to the relocalization of #chromatin-modifying proteins to #DNA breaks, causing cells to lose their identity, a hallmark of yeast #aging."
3/5 "Using a system called “#ICE” (#inducible changes to the #epigenome), we find that the act of faithful #DNA #repair advances aging at #physiological, #cognitive, and #molecular #levels, including #erosion of the #epigenetic #landscape,..."
Study from @salkinstitute found that partial reprogramming using the #Yamanaka transcription factors (#Oct4, #Sox2, #Klf4 & #cMyc) for short periods of time:
-restored a youthful #epigenetic signature to #aging cells & extends the life span of a #premature #aging mouse model.
-restored a youthful #epigenetic signature to #aging cells & extends the life span of a #premature #aging mouse model.
-long-term partial reprogramming led to rejuvenating effects in different tissues, such as the #kidney & #skin, and at the #organismal level; duration of the treatment determined the extent of the beneficial effects.
-The rejuvenating effects were associated with a reversion of the #epigenetic clock and metabolic and #transcriptomic changes, including reduced expression of genes involved in the #inflammation, #senescence & #stressresponse pathways.
nature.com/articles/s4358…
nature.com/articles/s4358…
#vaccins #ARNm & #dissensus : une longue vulgarisation de qualité ici sur leur mécanique, le risque de retranscription ADN et les précautions associées...
Jean-Yves Bilien interviewe le Dr Nawrocki qui débunke les mythes des jeunes médecins surs d'eux 😳 odysee.com/@Glorian:b/Dr-…
Jean-Yves Bilien interviewe le Dr Nawrocki qui débunke les mythes des jeunes médecins surs d'eux 😳 odysee.com/@Glorian:b/Dr-…
#sûreté #vaccinale : Accrochez-vous 😳 en très gros, le Spike serait mortel à petit feu, car induisant des anticorps contre la cardiolipine, sorte de gardien cellulaire dont l'absence déclenche la mort cellulaire... 😱 sources en bas du thread ⏬ Qui veut un 💉 au spike?
#sureté #vaccinale : Nouvelle alerte sur le risque de maladies dégénératives induites par la #présence de Spike dans le cerveau 😱
Livetweets from the 7th Annual Aging Research and Drug Discovery conference #ARDD2020. I can't attend every talk to coverage will be intermittent. Apologies to any speakers left out!
Christian Riedel from @karolinskainst presenting aging clocks. There are a lot of these, but excited to see him (A) making a human clock predicting time to death, not just age, and (B) deconvoluting both their human and model org clocks into FUNCTIONAL parameters. Sorely needed.
Now haut.ai from Estonia arguing that hand photos are more robust than faces for AI-based aging biomarkers, and that we need more explicit skin tone features for broadly applicable tools.
PS, Estonia is probably the world leader in digital health/EHRs.
PS, Estonia is probably the world leader in digital health/EHRs.
Cool #Senescence paper #2, in @JCI_insight: insight.jci.org/articles/view/….
@marissa_schafer, Xu Zhang, @NKLeBRASSEUR & team dive into the details of SASP, the Senescence Associated Secretory Phenotype first discovered in the Campisi lab @BuckInstitute.
@marissa_schafer, Xu Zhang, @NKLeBRASSEUR & team dive into the details of SASP, the Senescence Associated Secretory Phenotype first discovered in the Campisi lab @BuckInstitute.
SASP is a prime suspect for how #Senescent cells cause #Inflammation, #Cancer and #Fibrosis. But SASP is a mix of many secreted proteins, so the @MayoClinic looked closely at 24 factors.
1st, they show which factors are secreted by different cell types (in culture).
1st, they show which factors are secreted by different cell types (in culture).
Next, and more exciting, they measured which SASP factors increase with age in human blood. #ChronicInflammation is an important mechanism of aging, but really defining #ChronicInflammation is hard and often not even attempted. So this detailed analysis is great.
Time to catch up on some #Senescence papers, starting with beautiful work by @corina_amor_MD, Judith Freucht & @JosefLeibold. They used #CART #CellTherapy to clear #Senescent cells, and you'll never guess what happened next! nature.com/articles/s4158…
Just kidding, you guessed it: disease model mice got better. Props to the authors for A) inducing #Senescence in 3 different ways, B) using 2 models of #NASH/liver #Fibrosis, and C) validating their senescence observations in human samples of #Cancer and #Atherosclerosis.
The linchpin of the paper was identifying a specific membrane marker on #Senescent cells, uPAR. They used bulk #Transcriptomics to identify candidates, then narrowed down with #Proteomic data. Go #Omics!
They didn't explore whether uPAR is causative for the #Senescent phenotype.
They didn't explore whether uPAR is causative for the #Senescent phenotype.
Nostalgic to be back at Bay Area Aging Meeting #BAAM. Shortly after moving to the Bay, I remember being blown away that this free, local symposium was of the same caliber as a Keystone meeting. Meeting is bigger than ever, as #agingbiology goes mainstream. #creatingtime.
Great talks by students and postdocs from @BrunetLab, @wysscoray lab, @czbiohub, @RobertoZoncu lab, @VilledaLab, and many more. Other than the keynote by @DMSabatini, everything is focused on giving #trainees a chance to present unpublished work.💚
@BrunetLab @wysscoray @czbiohub @RobertoZoncu @VilledaLab @DMSabatini And @calico is finally giving talks, after lurking at our meeting for several years😄 Scott McIsaac talking about their MAD machine for collecting old yeast cells out of a continuously replicating population. They can get millions of cells for genomics assays.
