Discover and read the best of Twitter Threads about #Senescent
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Cool #Senescence paper #2, in @JCI_insight: insight.jci.org/articles/view/….
@marissa_schafer, Xu Zhang, @NKLeBRASSEUR & team dive into the details of SASP, the Senescence Associated Secretory Phenotype first discovered in the Campisi lab @BuckInstitute.
@marissa_schafer, Xu Zhang, @NKLeBRASSEUR & team dive into the details of SASP, the Senescence Associated Secretory Phenotype first discovered in the Campisi lab @BuckInstitute.
SASP is a prime suspect for how #Senescent cells cause #Inflammation, #Cancer and #Fibrosis. But SASP is a mix of many secreted proteins, so the @MayoClinic looked closely at 24 factors.
1st, they show which factors are secreted by different cell types (in culture).
1st, they show which factors are secreted by different cell types (in culture).
Next, and more exciting, they measured which SASP factors increase with age in human blood. #ChronicInflammation is an important mechanism of aging, but really defining #ChronicInflammation is hard and often not even attempted. So this detailed analysis is great.
Time to catch up on some #Senescence papers, starting with beautiful work by @corina_amor_MD, Judith Freucht & @JosefLeibold. They used #CART #CellTherapy to clear #Senescent cells, and you'll never guess what happened next! nature.com/articles/s4158…
Just kidding, you guessed it: disease model mice got better. Props to the authors for A) inducing #Senescence in 3 different ways, B) using 2 models of #NASH/liver #Fibrosis, and C) validating their senescence observations in human samples of #Cancer and #Atherosclerosis.
The linchpin of the paper was identifying a specific membrane marker on #Senescent cells, uPAR. They used bulk #Transcriptomics to identify candidates, then narrowed down with #Proteomic data. Go #Omics!
They didn't explore whether uPAR is causative for the #Senescent phenotype.
They didn't explore whether uPAR is causative for the #Senescent phenotype.
Revolutionary study.
Resistance #exercise causes rapid clearance of #senescent cells in human skeletal muscle.
Resistance exercise is an ideal #senolytic
ncbi.nlm.nih.gov/pmc/articles/P…
Resistance #exercise causes rapid clearance of #senescent cells in human skeletal muscle.
Resistance exercise is an ideal #senolytic
ncbi.nlm.nih.gov/pmc/articles/P…
@Mangan150
If Resistance Exercise is a "Senolytic for the Muscle", a program should be developed for the very elderly especially including those in very bad health, who as i assume (not an expert) avoid resistance exercise, even if practicing something else
If Resistance Exercise is a "Senolytic for the Muscle", a program should be developed for the very elderly especially including those in very bad health, who as i assume (not an expert) avoid resistance exercise, even if practicing something else
