Discover and read the best of Twitter Threads about #agingbiology
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Something is changing about how scientific research is funded.
@Jasonmmast @endpts covers a growing set of science funding experiments: endpts.com/inside-the-mul…
@Jasonmmast @endpts covers a growing set of science funding experiments: endpts.com/inside-the-mul…
These include high-throughput grants (e.g. #Fast, #Impetus), new institutes (@ArcadiaScience, @AltosLabs, @arcinstitute... I guess A is for new beginnings?), and new structures like 'nonprofit startups' (@Convergent_FROs) & @newscienceorg.
As with all experiments, I expect that some of these will disappear and that others will be a central part of science in ten years.
But them happening at all is enough to renew a conversation about how science is funded and conducted.
But them happening at all is enough to renew a conversation about how science is funded and conducted.
💸 98 Longevity Impetus Grants were awarded in 2021, thanks to generous donations from @juanbenet @jamesfickel @VitalikButerin @JedMcCaleb @KarlPfleger @FEhrsam and 1 anonymous donor.
I'll summarize outcomes in this thread, awardees listed in prior one:
I'll summarize outcomes in this thread, awardees listed in prior one:
🦸🏽 While I've been doing most of the tweeting, the Longevity Apprentices @LNuzhna @kush__sharma @edmarferreira & Tara Mei are the real heroes for running the operations.
This has been a great Apprenticeship project, merging action and exposure to research
martinborchjensen.com/apprenticeship
This has been a great Apprenticeship project, merging action and exposure to research
martinborchjensen.com/apprenticeship
🚅 The review + awards process was fairly smooth, thanks in part to @kush__sharma's custom reviewer UI. Several reviewers told us unprompted that it was their best review experience ever; the UI took 2 wks to make, so there's low hanging fruit for other agencies in that area.
Thrilled to announce the Longevity #Impetus Grants, $21M+ towards basic research that could accelerate our understanding and control of human aging.
We welcome proposals from researchers in- and outside the #Aging field. Please share!
More info: impetusgrants.com & this 🧵
We welcome proposals from researchers in- and outside the #Aging field. Please share!
More info: impetusgrants.com & this 🧵
Impetus Grants are $10k-500k (w max 10% overhead). Smaller requests favored, to support more projects. No project period and no strings attached. Scientists at non-profits worldwide can apply with ideas that shift perspectives & capabilities in #Aging research, starting Sep 13th.
Inspiration came from @tylercowen & @patrickc's #COVID19 Fast Grants. Their team made funding decisions in 2 weeks, and the grants have already led to both discoveries and better tools for #testing.
If it's feasible to fund science this way, shouldn't we? future.a16z.com/what-we-learne…
If it's feasible to fund science this way, shouldn't we? future.a16z.com/what-we-learne…
I'm often asked how to learn about #AgingBiology, which I hope this thread can address.
Will first list recommended introductory resources, then contextualize and interpret.
There's exciting progress! But also many fanciful ideas, so you can't take everything at face value.
Will first list recommended introductory resources, then contextualize and interpret.
There's exciting progress! But also many fanciful ideas, so you can't take everything at face value.
Will mostly skip the Why/philosophy of #AntiAging, since those asking for resources are likely already bought in.
If interested I wrote a Why/Why not post back in 2016: martinborchjensen.com/hypotheses/agi…, and most of the websites I'll list have a version of this discussion too.
If interested I wrote a Why/Why not post back in 2016: martinborchjensen.com/hypotheses/agi…, and most of the websites I'll list have a version of this discussion too.
The most comprehensive #Aging primer is @ArtirKel's FAQ: nintil.com/longevity.
It does a great job of introducing the field, and distilling the science for non-biologists. Bonus points for contextualizing how biology is different from engineering.
It does a great job of introducing the field, and distilling the science for non-biologists. Bonus points for contextualizing how biology is different from engineering.
Cool #Senescence paper #2, in @JCI_insight: insight.jci.org/articles/view/….
@marissa_schafer, Xu Zhang, @NKLeBRASSEUR & team dive into the details of SASP, the Senescence Associated Secretory Phenotype first discovered in the Campisi lab @BuckInstitute.
@marissa_schafer, Xu Zhang, @NKLeBRASSEUR & team dive into the details of SASP, the Senescence Associated Secretory Phenotype first discovered in the Campisi lab @BuckInstitute.
SASP is a prime suspect for how #Senescent cells cause #Inflammation, #Cancer and #Fibrosis. But SASP is a mix of many secreted proteins, so the @MayoClinic looked closely at 24 factors.
1st, they show which factors are secreted by different cell types (in culture).
1st, they show which factors are secreted by different cell types (in culture).
Next, and more exciting, they measured which SASP factors increase with age in human blood. #ChronicInflammation is an important mechanism of aging, but really defining #ChronicInflammation is hard and often not even attempted. So this detailed analysis is great.
Nostalgic to be back at Bay Area Aging Meeting #BAAM. Shortly after moving to the Bay, I remember being blown away that this free, local symposium was of the same caliber as a Keystone meeting. Meeting is bigger than ever, as #agingbiology goes mainstream. #creatingtime.
Great talks by students and postdocs from @BrunetLab, @wysscoray lab, @czbiohub, @RobertoZoncu lab, @VilledaLab, and many more. Other than the keynote by @DMSabatini, everything is focused on giving #trainees a chance to present unpublished work.💚
@BrunetLab @wysscoray @czbiohub @RobertoZoncu @VilledaLab @DMSabatini And @calico is finally giving talks, after lurking at our meeting for several years😄 Scott McIsaac talking about their MAD machine for collecting old yeast cells out of a continuously replicating population. They can get millions of cells for genomics assays.
