Discover and read the best of Twitter Threads about #FMT
Most recents (18)
[World #IBSAwarenessMonth] Dear #HCPs👩⚕️ & #Microbiota community👨🔬, April is dedicated to raising awareness about #IrritableBowelSyndrome
During the month, @Microbiota_Inst will provide you with content about #IBS, a common & complex #disease
#GutHealth #LetsTalkIBS #thread👇
During the month, @Microbiota_Inst will provide you with content about #IBS, a common & complex #disease
#GutHealth #LetsTalkIBS #thread👇
[World #IBSAwarenessMonth]
🔎 You will:
👉better understand the🔗between #IBS & #microbiota
👉discover potential ways to manage the #disease
👉learn to make a #diagnosis with our #CME courses, #videos & a professionally designed #tool
👉improve communication with your #patients
🔎 You will:
👉better understand the🔗between #IBS & #microbiota
👉discover potential ways to manage the #disease
👉learn to make a #diagnosis with our #CME courses, #videos & a professionally designed #tool
👉improve communication with your #patients
[World #IBSAwarenessMonth]
1️⃣ In this sequence, learn more about the link between #microbiota and #IrritableBowelSyndrome.
#IBS #MedTwitter #GITwitter #GutHealth #LetsTalkIBS #DGBI #FGID #GIfellows #TakeIBSSeriously
Take a look! 👇
1️⃣ In this sequence, learn more about the link between #microbiota and #IrritableBowelSyndrome.
#IBS #MedTwitter #GITwitter #GutHealth #LetsTalkIBS #DGBI #FGID #GIfellows #TakeIBSSeriously
Take a look! 👇
@juanpabloarab now covers the therapy landscape for alcohol-associated hepatitis - steroids suboptimal with benefits beyond 1 month limited #TLM22
Microbiota-based therapeutics in the treatment of recurrent Clostridioides difficile 🦠
@DrPaulGastro @Khanna_S @caterina_oneto
#MedTwitter #GITwitter #IDTwitter #ACG2022 #Cdiff
@DrPaulGastro @Khanna_S @caterina_oneto
#MedTwitter #GITwitter #IDTwitter #ACG2022 #Cdiff
Pathogenesis of CDI
1. Disruption of #microbiome (antibiotics) ▶️ loss of colonization resistance
2. Colonization
3. Spore ▶️ vegetative ▶️ toxin
4. Recurrence cycle or restoration of microbiota
1. Disruption of #microbiome (antibiotics) ▶️ loss of colonization resistance
2. Colonization
3. Spore ▶️ vegetative ▶️ toxin
4. Recurrence cycle or restoration of microbiota
Antibiotics control acute disease, but do not protect against recurrence
🧵Microbiota: can they prevent #TID?
Incidence of T1D is rising particularly in the young.
Environmental factors could drive this pattern observed across the globe.
-N. Hanssen
#ISPAD #ISPAD2022 #dedoc°voices #NothingAboutUsWithoutUs #payitforward @dedocORG @ispad_org 1/n
Incidence of T1D is rising particularly in the young.
Environmental factors could drive this pattern observed across the globe.
-N. Hanssen
#ISPAD #ISPAD2022 #dedoc°voices #NothingAboutUsWithoutUs #payitforward @dedocORG @ispad_org 1/n
Microbiota: can they prevent #TID?
+ rapid destruction of #BetaCells in kids than adults.
#PwD with residual beta cells have higher #TIR.
-N. Hanssen
#ISPAD #ISPAD2022 #dedoc°voices #NothingAboutUsWithoutUs #payitforward @dedocORG @ispad_org 2/n
+ rapid destruction of #BetaCells in kids than adults.
#PwD with residual beta cells have higher #TIR.
-N. Hanssen
#ISPAD #ISPAD2022 #dedoc°voices #NothingAboutUsWithoutUs #payitforward @dedocORG @ispad_org 2/n
Microbiota: can they prevent #TID?
Poor discrimination between self/not self [#autoimmunity] happens with loss of gut microbiome.
-N. Hanssen
#ISPAD #ISPAD2022 #dedoc°voices #NothingAboutUsWithoutUs #payitforward @dedocORG @ispad_org 3/n
Poor discrimination between self/not self [#autoimmunity] happens with loss of gut microbiome.
-N. Hanssen
#ISPAD #ISPAD2022 #dedoc°voices #NothingAboutUsWithoutUs #payitforward @dedocORG @ispad_org 3/n
Very pleased (& proud) that our meta-study of microbiome dynamics following #FMT is out today in @NatureMedicine
Congrats to @simone_s_li @BorkLab & collaborators @embl @amsterdamumc @WUR & CDD.
What happens after FMT? It's messy...
1/
nature.com/articles/s4159…
Congrats to @simone_s_li @BorkLab & collaborators @embl @amsterdamumc @WUR & CDD.
What happens after FMT? It's messy...
1/
nature.com/articles/s4159…
We started from the realisation that diff smaller studies on #FMT had come to v diff conclusions on microbiome dynamics. So we collected public and newly generated data from 316 FMTs across different indications and conducted a metagenomic meta-study.
2/
2/
We built #pangenome|s from 47k newly generated MAGs and 25k ref genomes for a total of >1k species and profiled strain populations in each sample based on microbial Single Nucleotide Variants and gene presence/absence.
3/
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@halesj126 @MondayNightIBD @dunleavy_katie @SanjeevaniTomar @yaransarkis @RomyChamoun @BassiMehak @JosephHabibi_MD @DCharabaty @DSTEINGIMD @BeniwalPatelMD #CDI treatment:
💎🚫 oral 💊 metronidazole in #IBD
💎@AmCollegeGastro 👇
bit.ly/ACG-Guideline-…
💎IDSA : fidaxo > vanco
💎IBD pts might require a longer course
Non-severe:
💊 fidaxo x 10d
OR
💊 vanco x 14-21d
Severe:
💊 fidaxo x 10d
OR
💊 vanco x 21d
➕/➖ 💉 metronidazole
💎🚫 oral 💊 metronidazole in #IBD
💎@AmCollegeGastro 👇
bit.ly/ACG-Guideline-…
💎IDSA : fidaxo > vanco
💎IBD pts might require a longer course
Non-severe:
💊 fidaxo x 10d
OR
💊 vanco x 14-21d
Severe:
💊 fidaxo x 10d
OR
💊 vanco x 21d
➕/➖ 💉 metronidazole
@halesj126 @MondayNightIBD @dunleavy_katie @SanjeevaniTomar @yaransarkis @RomyChamoun @BassiMehak @JosephHabibi_MD @DCharabaty @DSTEINGIMD @BeniwalPatelMD @AmCollegeGastro #CDI treatment cont’d:
Fulminant:
💊 vanco
➕
💉 metronidazole
➕
Vanco enema if ileus
Additionally:
✳️ supportive cares
✳️ 🔪 consult
✳️ 🤔 #FMT 💩🔦
Fulminant:
💊 vanco
➕
💉 metronidazole
➕
Vanco enema if ileus
Additionally:
✳️ supportive cares
✳️ 🔪 consult
✳️ 🤔 #FMT 💩🔦
@halesj126 @MondayNightIBD @dunleavy_katie @SanjeevaniTomar @yaransarkis @RomyChamoun @BassiMehak @JosephHabibi_MD @DCharabaty @DSTEINGIMD @BeniwalPatelMD @AmCollegeGastro As the saying goes an algorithm is worth a 1000 words and fortunately, we have the great @wabillin algo on how to approach CDI in IBD
🧵12 scientific Twitter accounts you should go follow for the latest updates on #GutMicrobiome-host interaction research: 🦠👩🔬🧪⬇️
#aging #immune #nutrition #probiotics #brain #SciComm
#aging #immune #nutrition #probiotics #brain #SciComm
1/12. @bykriscampbell - Kristina Campbell, MSc, is a #SciComm extraordinaire. Her tweets give excellent summaries of cutting edge #GutMicrobiome-host publications primarily #FMT #probiotics and #Disease
2/12. @john_damianosMD - Dr. John Damianos tweets about all things #Microbes and #Medicine. We're talking #Probiotics, #IBD, and more, from the prospective of a clinician.
#Probiotics, #antibiotics, #FMT, and other #microbiome therapies in C. difficile with @DrPaulGastro
@AmCollegeGastro #ACG2021
@AmCollegeGastro #ACG2021
Spore phase is resistant to gastric acid and alcohol-based hand sanitizers.
A healthy #microbiome protects against the development of CDI
Read 27 tweets
⭐️The new C. difficile guidelines!
Here are the 🧠s behind the new guidelines!
What's in a name?
Clostridium difficile ▶️ clostridioides difficile
Clostridium difficile ▶️ clostridioides difficile
A 🧵on our new work on preclinical #FaecalMicrobiomeTransplantation studies!
A while back, I began to plan my own #FMT study.
Turns out, the literature is wildly varied but mainly it is pretty difficult to find a protocol that has all the nitty gritty detail you need.
1/
A while back, I began to plan my own #FMT study.
Turns out, the literature is wildly varied but mainly it is pretty difficult to find a protocol that has all the nitty gritty detail you need.
1/
So me and my team (@kate_secombe @GhanyahA @CourtneySubra11 @JacquiScott0 @YsabellaVan @JoanneBowen_UoA) and some incredible collaborators (@jfcryan @CassGheorghe @caitlincowanPhD @Matt_Snelson @UCCpsychiatry) decided to do something about it!
@Pharmabiotic @UniofAdelaide
2/
@Pharmabiotic @UniofAdelaide
2/
We systematically reviewed all #FMT studies (in mice) in the past decade, extracting all the methodological details they used/reported.
3/
3/
🚨New @AmCollegeGastro guidelines for the treatment of irritable bowel syndrome! I will summarize in this🧵 ⬇️⬇️⬇️
journals.lww.com/ajg/Abstract/9…
Authors: #BrianLacy, @MarkPimentelMD, @dbrennerGIMD, @umfoodoc, @drlauriekeefer, @MLongMD, @BMoshiree
#GITwitter #GI #IBS #gut #MedEd
journals.lww.com/ajg/Abstract/9…
Authors: #BrianLacy, @MarkPimentelMD, @dbrennerGIMD, @umfoodoc, @drlauriekeefer, @MLongMD, @BMoshiree
#GITwitter #GI #IBS #gut #MedEd
🔘In pts w diarrhea, rule out #celiac disease🍞
🔘In pts w diarrhea + no🚨features, check fecal calprotectin/fecal leukocytes AND CRP to rule out #IBD
🔘❌routine 💩testing for enteric pathogens in #IBS
🔘❌colonoscopy in IBS if <45 and no🚨s
🔘Make POSITIVE IBS dx (Rome), ❌DOE
🔘In pts w diarrhea + no🚨features, check fecal calprotectin/fecal leukocytes AND CRP to rule out #IBD
🔘❌routine 💩testing for enteric pathogens in #IBS
🔘❌colonoscopy in IBS if <45 and no🚨s
🔘Make POSITIVE IBS dx (Rome), ❌DOE
🔘Identify #IBS subtype to target therapy
🔘❌testing for food allergies/sensitivities
🔘Test anorectal physiology in pts w IBS + symptoms suggestive of pelvic floor disorder +/or refractory #constipatoin
🔘Limited trial of low-#FODMAP #diet
🔘✅soluble fiber,❌insoluble fiber
🔘❌testing for food allergies/sensitivities
🔘Test anorectal physiology in pts w IBS + symptoms suggestive of pelvic floor disorder +/or refractory #constipatoin
🔘Limited trial of low-#FODMAP #diet
🔘✅soluble fiber,❌insoluble fiber
Recapping @AmCollegeGastro's #VirtualGrandRounds on #IBS! Let's begin!
🟣IBS can be diagnosed with the Rome criteria
🟣Making a positive diagnosis is very helpful to patients, many of whom have gone years without a name for their symptoms
🟣IBS can be diagnosed with the Rome criteria
🟣Making a positive diagnosis is very helpful to patients, many of whom have gone years without a name for their symptoms
#IBS is heterogeneous, and so are its pathogenesis and pathophysiology.
🟣Identifying underlying factors in patients can help target treatment!
@AmCollegeGastro
🟣Identifying underlying factors in patients can help target treatment!
@AmCollegeGastro
1mo writing, 4mo #PeerReview
Finally! Our invited #publication on #infections in #cirrhosis World Journal of #Hepatology
Update on diagnosis and management of sepsis in cirrhosis
Full paper: bit.ly/32shuv6
Exhaustive discussions, new stuff..1/4
#livertwitter #MedTwitter
Finally! Our invited #publication on #infections in #cirrhosis World Journal of #Hepatology
Update on diagnosis and management of sepsis in cirrhosis
Full paper: bit.ly/32shuv6
Exhaustive discussions, new stuff..1/4
#livertwitter #MedTwitter
...a lot of important defining and prognosis powered scoring systems used in #sepsis 2/4
#MedStudentTwitter
#MedStudentTwitter
Team tests hypothesis that #FMT from aged donor mice into adult recipients cld impact #brain functions associated w/ #aging 👉 Find that FMT from aged donors led to impaired spatial learning and memory in adult recipients: biorxiv.org/content/10.110…
2/ FMT from aged mice also modulated expression of a variety of proteins implicated in maintenance of #synaptic plasticity + neurotransmission in the #hippocampus☝️and #microglia cells of the hippocampus fimbria acquired an aging-like phenotype
3/ The trends must be replicated/tested in humans! 👉 But, it makes my long-held contention that the #microbiome is involved in #aging processes less “crazy”😉 For more background check out this webinar I did on the topic w/ @mike_lustgarten + @subC0smos:
This! The activity of the host #immune response largely determines whether #pathobionts acquired from an #FMT donor might become capable of virulence 👉 So including immune status in the study of FMT outcomes would be extremely informative
IMO immune status should be included in the general study of #antibiotic resistant infection 👉 It’s no coincidence that most “superbug” infections occur in immunocompromised patients, often in hospitals (w/ patients on cocktails of steroids for procedures like organ transplants)
Because extrapolate that trend and consider that the immunosuppressive biologics used to palliate “#autoimmune” disease symptoms are the top selling medications in the world 👉 With top side effects of such drugs being “serious #infection by viruses, fungi or bacteria”(see below)
