Discover and read the best of Twitter Threads about #TLM22
Most recents (4)
Calvin Pan now presents on maternal TDF for prevention of vertical transmission in highly viraemic mothers #TLM22 clinicaltrials.gov/ct2/show/NCT03…
280 HBeAg+ mothers gestational age 12-13 weeks randomised 1:1 to early TDF from GW 14, or control group of TDF at GW 28. All infants got active immunoprophylaxis and HBIg only given to infants in the control group; 1ry endpoint HBV transmission at 28 weeks #TLM22
Women in experimental arm had lower HBV DNA at delivery; there was no transmission of HBV to infants in either group. A sensitivity analysis suggested a conservative 2% infection rate in experimental arm. Safety similar, but small numbers #TLM22
@juanpabloarab now covers the therapy landscape for alcohol-associated hepatitis - steroids suboptimal with benefits beyond 1 month limited #TLM22
Some classic genetic stories, and some more recent ones… #TLM22 
Giving the Thomas Starzl transplant state of the art lecture this year is Peter Friend, on normothermic transplantation — the ice box is now the rate limiting step, especially for extended criteria organs #TLM22 @OxTxResearch
Published trials for benefits of normothermic perfusion devices accumulating, typically reduced acute liver injury, post-reperfusion syndrome, utilisation, and preservation time - but randomisation process in this setting introduces inherent selection biases #TLM22
Upcoming PLUS trial uses a prospective NMP arm and identical criteria retrospective control arm, given investigators unwilling to randomise higher risk of organs #TLM22
