Discover and read the best of Twitter Threads about #CELL
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Research indicates that metabolic pathways play a significant role in regulating the aging process of organisms, suggesting that manipulating metabolism can potentially enhance healthspan and lifespan. (1/15)
So much so, that scientists are currently exploring dietary interventions and compounds that can modulate metabolism as potential anti-aging strategies. (2/15) doi.org/10.1016/j.bj.2…
One particular focus of metabolic interventions aimed at delaying aging is cellular senescence. (3/15)
1/As promised & after reading $CRSP latest Q4 2022 #financial #report here is my impression regarding @CRISPRTX latest corporate status. I have focused only on the main issues that I found to be the most interesting & relevant. #CRISPR #BioTech #FinTwit #Genomics #GeneEditing 🧵 
2/IMO the most significant corporate event in Q4 was $CRSP announcement that regulatory Exa-cel submissions of both #SickleCell & #BetaThalassemia validated in the #EU & #UK & that the @US_FDA BLA submission is on track by the end of Q1 ‘23 - possibly reaching the #markets in ‘23
3/Exa-cel/CTX001 - the key program in $CRSP portfolio, is an #autologous Ex-Vivo #CRISPR/#Cas9 #GeneEditing therapy aimed for patients suffering from #TDT or severe #SCD. The latest readout for both programs was phenomenal with 42/44 TDT & 31/31(!) demonstrated remarkable results
1/@LineageCell announced it entered an exclusive option & license agreement with $ERNA for the development of novel B2M deficient induced pluripotent #stem #cell #iPSC by using Eterna’s #GeneEditing technology thus developing therapies for #CNS diseases. #BioTech #CRISPR $LCTX
2/The new cell lines - to be developed by $ERNA, will support the creation of additional product candidates at $LCTX and specifically for the treatment of central #nervoussystem #CNS disorders & other #neurology targets via Eterna’s IP #CRISPR collaboration with @FactorBio
3/This agreement will also allow @LineageCell to enter the #CRISPR field and will provide $LCTX an option to obtain an exclusive license to utilize & sublicense $ERNA novel #GeneEditing cell lines for #preclinical, #clinical, & commercial purposes in the field of CNS diseases.
Una chica acusa a @auronplay de ********
Claudia Galera, nació el 29 de diciembre del 1998.
Estos son todos sus @ que tiene o tenía.
Twitter:
@ xkaysua
@ KlauConxdemixta
@ killedByDeath__
@ KISSMEG00DBYE
Instagram:
@ kissedbydeath_
@ xKay.mua
@ Killedbydeath__
Sigo...
Claudia Galera, nació el 29 de diciembre del 1998.
Estos son todos sus @ que tiene o tenía.
Twitter:
@ xkaysua
@ KlauConxdemixta
@ killedByDeath__
@ KISSMEG00DBYE
Instagram:
@ kissedbydeath_
@ xKay.mua
@ Killedbydeath__
Sigo...
Confirmamos que Claudia era menor de edad en aquella época ( 2013)
DNI, última letra del apellido acaba por A, ella se apellida "Galera", como hemos podido encontrar en diversas publicaciones.
(maquilladora)
DNI, última letra del apellido acaba por A, ella se apellida "Galera", como hemos podido encontrar en diversas publicaciones.
(maquilladora)
Si que es verdad que se relacionaba con gente mayor que ella, siempre ha sido así desde hace tiempo.
Sus amigas, en 2013, muchas mayores de edad como @ misfitstormer, que gracias a sus historias se puede saber que es mayor que Claudia.
O @ gingernyx (Del 1993)
Sus amigas, en 2013, muchas mayores de edad como @ misfitstormer, que gracias a sus historias se puede saber que es mayor que Claudia.
O @ gingernyx (Del 1993)
1/2 Compelling share from @oliver_phil...
"Remarkably, previously #hospitalized and #nonhospitalized patients remained with decreased numbers of CD1c+ #myeloid DCs and pDCs seven months after #SARSCoV2 #infection."
#COVID19 IS NOT #mild
"Remarkably, previously #hospitalized and #nonhospitalized patients remained with decreased numbers of CD1c+ #myeloid DCs and pDCs seven months after #SARSCoV2 #infection."
#COVID19 IS NOT #mild
2/2 "Moreover, the expression of #dendritic #cell (DC) markers such as #CD86 and #CD4 were only restored in previously #nonhospitalized patients, while no restoration of integrin β7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed."
#CovidIsNotOver
#CovidIsNotOver
1/@GraphiteBio presented preclinical results supporting the use of a single-#cell #RNA #sequencing method to assess #gene correction outcomes in #patients treated with nulabeglogene autogedtemcel (nula-cel) - GPH-101. #BioTech #CRISPR #GeneEditing #Genomics $GRPH #ASH22
2/GPH101 (nula-cel) is a #CRISPR #Cas9 #GeneEditing autologous #stem #cell-based #therapy in clinical development aimed to treat #SickleCellDisease. GPH101 is designed to directly correct the underlying mutation, thereby decreasing HbS production & restoring HbA expression #ASH22
3 $GRPH gene correction platform involves editing hematopoietic #stem cells found in the #bonemarrow that develop into various types of #blood #cells. Since red blood cells lose their genomic DNA during maturation-tracking #GeneEditing in mature cells via sequencing is impossible
#1 #Covid19 #Supplement thread for #LongCovid #LongHaul #PostCovid. This may help, if you suffer from #fatigue #brainfog #jointpain #inflammation #weakness #depression #anxiety #SOB #clots #fibrosis #myocarditis #heartattack #stroke #alz #memory frontiersin.org/articles/10.33…
#2 B-COMPLEX/MULTI VITAMIN. Buy a liposomal or other form that increases bio-availability. Take 1 capsule w/Breakfast and Lunch. If you have stomach upset, try sublingual (under tongue) EZ Melt B-Complex in AM & Multi w/iron for Dinner. amazon.com/Liposomal-Meth…
#3 OMEGA 3s. Fish Oil, Krill Oil, Algae Oil are all good sources of Omega 3. Be careful the EPA/DHA ratio. EPA helps with inflammation/DHA helps with cognition. You need both! Opt for a 1:1 or 2:1 ratio of DHA to EPA (2:1 ratio eg. 800 DHA/400EPA) amazon.com/3Care-Concentr…
How precise are noisy #morphogen gradients in #tissue #patterning?
It turns out that the positional information they convey to #cells in the #neuraltube is much more accurate than previously estimated!
Our new #devbio paper is out in @NatureComms: rdcu.be/cH8Fx
It turns out that the positional information they convey to #cells in the #neuraltube is much more accurate than previously estimated!
Our new #devbio paper is out in @NatureComms: rdcu.be/cH8Fx
A methodological subtlety has previously led to overestimated positional errors of the morphogen gradients in the mouse neural tube. We reanalysed the noisy gradients and found that the positional information they can convey to cells is actually orders of magnitude more precise.
Also, morphogen gradients in differently sized tissues must not be pooled and rescaled to their mean length, or else an artificial positional error is added.
Just a friendly reminder @moderna_tx told the @SECGov that the @US_FDA defines #mRNA as gene therapy. And called it an unprecedented new category of #medicines tho they really want that #vaccine classification anyways for liability protections & fear the public wouldn’t take it.
We want to shed some light on what's going on in recent media reports about #5G signal interference and civilian aircraft. So, what are we talking about?
Thread:
Thread:
All communications equipment like #cell phones, connected home devices and smart watches operate at a specific #radio frequency, meaning the device is designed to send and receive signals only on approved allocated #frequency bands.
For example, you're probably familiar with the #radio in your car. No not your streaming service, your regular ol' trusty radio.
🟢[Long-thread] Face à #Omicron :
Immunité humorale réduite
Immunité cellulaire reste préservée
2 doses de vaccin sont insuffisantes =) ↗️Infections
3 doses de vaccin offrent une meilleure protection
Peu de formes graves observées
Tests antigéniques moins sensibles
1/24⤵️
Immunité humorale réduite
Immunité cellulaire reste préservée
2 doses de vaccin sont insuffisantes =) ↗️Infections
3 doses de vaccin offrent une meilleure protection
Peu de formes graves observées
Tests antigéniques moins sensibles
1/24⤵️
1⃣Immunité humorale réduite avec #Omicron
Ce rapport a montré que : #Omicron échappe à la plupart des thérapies par anticorps monoclonaux et dans une large mesure, aux anticorps provoqués par les vaccins.
2/24⤵️
Ce rapport a montré que : #Omicron échappe à la plupart des thérapies par anticorps monoclonaux et dans une large mesure, aux anticorps provoqués par les vaccins.
2/24⤵️
Selon cet article publié dans #Nature le 23/12 : Pour tous les participants (infectés et vaccinés , vaccinés seulement) : le titre moyen d’anticorps a diminué de 1963 avec le virus ancestral à 89 avec Omicron, donc une baisse du titre d'Ac d’un facteur 22 avec Omicron.
3/24⤵️
3/24⤵️
Inadvertent Pumping in too much of Zinc!could this also be contributing to this epidemic of #mucormycosis #blackfungus in association with other risk factors...!? @MoHFW_INDIA @ProfSomashekhar @BagaiDr @iiscbangalore @ShamikaRavi @ICMRDELHI @ARanganathan72
ncbi.nlm.nih.gov/pmc/articles/P…
ncbi.nlm.nih.gov/pmc/articles/P…
ipen.br/biblioteca/200… is this coincidental...!!
ncbi.nlm.nih.gov/pmc/articles/P… we seem to be pushing the already susceptible by feeding the #BlackFungus with more and more #zinc by negating the “nutritional immunity”...
After 6 months of #lockdown and #lab shutdown I spent a full day 9 am-8 pm in lab doing experiments! New #grad students in #lifesciences: There is always light 💡 and #fluorescent images at the end of the tunnel! Filing a #patent on my #invention from #phd work soon @OrganOnAChip
This is an Organ on a Chip platform that enables mimicking #tissues and #organs in a high throughput manner! The main focus will be towards developing #mucosal organs with tissue resident #immune cells and lining #epithelial cells for #testing #COVID19 treatments #covidvaccines
I recently gave a talk at #oooc2020 organized by @GVNlab at @Columbia. In the talk I demonstrated the #ease of fabrication, #functionality, and #modularity of this platform.
We’re open to #collaborate with interested #researchers! Interested to learn more:
We’re open to #collaborate with interested #researchers! Interested to learn more:
#Advice - #DONT drink #AloeVera or eat its #extracts
📌Very #liver #toxic, especially #cirrhosis
📌Possibly cause #Cancer
📌Damage #cell #DNA
See: bit.ly/2BXHcyy & bit.ly/31gINb4
👇patient #liverbiopsy - lightpink area all liver cells #DEAD
#livertwitter
1/2
📌Very #liver #toxic, especially #cirrhosis
📌Possibly cause #Cancer
📌Damage #cell #DNA
See: bit.ly/2BXHcyy & bit.ly/31gINb4
👇patient #liverbiopsy - lightpink area all liver cells #DEAD
#livertwitter
1/2
📌Check your #nutrition #supplements
📌Double check #famous #weightloss supplements
📌Aloe-Vera = #Herbal liver injury
📌Some benefit in #skincare #dermatology, nothingelse! bit.ly/33h0rOO
📌Always disclose to your #Doctor
#MedTwitter #MedStudentTwitter #Ayurveda
2/2
📌Double check #famous #weightloss supplements
📌Aloe-Vera = #Herbal liver injury
📌Some benefit in #skincare #dermatology, nothingelse! bit.ly/33h0rOO
📌Always disclose to your #Doctor
#MedTwitter #MedStudentTwitter #Ayurveda
2/2
Nobody follows this. Whole #plant is mostly used! #plantbased supplemental diets with whole Aloe-Vera for treating conditions like #diabetes and #jaundice leads to #catastrophe
#regulation = 0 in #India. All Aloe Vera treatments by #WhatsApp #Doctors
#regulation = 0 in #India. All Aloe Vera treatments by #WhatsApp #Doctors
@WhoWouldWin13 First, let's look at physicality.
@RondaRousey is 5 feet 7 inches tall and normally weighs 145-150 (Her walking weight. When she dehydrated before a UFC fight she got down to 135). @JordynneGrace however is five feet 3 and 150-160 pounds. Ronda obviously has a reach advantage
@RondaRousey is 5 feet 7 inches tall and normally weighs 145-150 (Her walking weight. When she dehydrated before a UFC fight she got down to 135). @JordynneGrace however is five feet 3 and 150-160 pounds. Ronda obviously has a reach advantage
@WhoWouldWin13 @RondaRousey @JordynneGrace right off the bat, but Jordynne has a sleight weight advantage.
She also has a strength advantage.
@JordynneGrace is a superbeast, arguably lbs for lbs the strongest woman in professional wrestling. She's not the strongest in the absolute sense (@NiaJaxWWE would be even
She also has a strength advantage.
@JordynneGrace is a superbeast, arguably lbs for lbs the strongest woman in professional wrestling. She's not the strongest in the absolute sense (@NiaJaxWWE would be even
@WhoWouldWin13 @RondaRousey @JordynneGrace @NiaJaxWWE stronger), but she's stronger than even @RondaRousey, and will be able to overpower her.
@RondaRousey is a former MMA fighter, but due to the quirks of Pro-Wrestling, she wont be able to bring her MMA skills fully to bear (otherwise she would be winning her matches far more
@RondaRousey is a former MMA fighter, but due to the quirks of Pro-Wrestling, she wont be able to bring her MMA skills fully to bear (otherwise she would be winning her matches far more
When you go home to do work, and your #SaskTel #cell #data are completely useless, you have to drive 30 kms to answer school emails in your car. Worst part? Calling customer service, put on hold... only to have a message saying closed. Really?!? Are rural people out of luck for?
This was tweeted from a parking lot, after 10 emails were responded to, I sent myself the links to the material I need tomorrow... oh, and I’ve been at work since 7:30am. Ya, I’m ticked. I don’t need the data - but to call out?!?
Finally... over an hour when I was hoping to be home and parked... with some semblance of signal. I know how First world I sound... but, my current role depends on these, and there was no notice or anything I could find hinting at the issue. End rant, hoping to relax/sleep.
"Life did not invent #DNA."
Experimental support for the #hotsprings hypothesis for life's origin: David Deamer of @ucsc on nucleic acid polymerization in the wet-dry cycling of Darwin's "warm little pond," powered by #geothermal. Lab results confirmed in #hydrothermal pools.
Experimental support for the #hotsprings hypothesis for life's origin: David Deamer of @ucsc on nucleic acid polymerization in the wet-dry cycling of Darwin's "warm little pond," powered by #geothermal. Lab results confirmed in #hydrothermal pools.
From "boring statistical partitioning" in the fission of early protocells to the complex #homeostasis-driven #mitosis of the cells we know - Doron Lancet of @WeizmannInstSci on the gradient between closure of #autocatalysis #networks to complex regulatory mechanisms of #biology.
"Life is an integrated nested network of dynamic #kinetic cycles."
Addy Pross emphasizes the importance of motion to the persistent forms of self-organizing #complexsystems at SFI today
Addy Pross emphasizes the importance of motion to the persistent forms of self-organizing #complexsystems at SFI today
New @dbkell paper describes how, in #Alzheimer’s disease, dormant #microbes in the #blood can re-activate to drive many forms of inflammation + #neuro symptoms 👉Microbe re-activation + virulence is tied to #iron dysregulation + resulting oxidative stress:frontiersin.org/articles/10.33…
The paper also describes mechanisms by which inflammation + oxidative stress (driven by re-activated blood #microbes)....can led to red blood #cell deformability and dysregulated nitric oxide (NO) synthesis in #Alzheimer’s patients:
Here are two images of deformed red #blood cells (RBCs) in #Alzheimer’s 👉 This #infection-induced deformability may impair delivery of #oxygen to the #brain☝️How do these findings compare to the RBC deformability recently described by @OpenMedF in ME/CFS?:bloodjournal.org/content/132/Su…
Hello, I am Edna Matta. I was born in #Ibague, known as #Colombia’s #CityofMusic. A beautiful place near snow-covered volcanos (Ruiz, Santa Isabel and Tolima), large expanses of paramo forest, lakes and streams where a diverse array of animal and plant species coexist
My story starts with #powerful, #strong #women in my #family. I was the third of 4 children and my mom #firstMentor had to raise us practically alone, since my father had to work in a different city, 20h away by car
My mom is a very #strong #woman that taught me #values, to #workhard and to be #self-sufficient #StrongWomen #StrongFamily
@IWS_Network #VoicesIWS /1
@IWS_Network #VoicesIWS /1
