Discover and read the best of Twitter Threads about #preclinical
Most recents (5)
1/@LineageCell announced it entered an exclusive option & license agreement with $ERNA for the development of novel B2M deficient induced pluripotent #stem #cell #iPSC by using Eterna’s #GeneEditing technology thus developing therapies for #CNS diseases. #BioTech #CRISPR $LCTX 
2/The new cell lines - to be developed by $ERNA, will support the creation of additional product candidates at $LCTX and specifically for the treatment of central #nervoussystem #CNS disorders & other #neurology targets via Eterna’s IP #CRISPR collaboration with @FactorBio
3/This agreement will also allow @LineageCell to enter the #CRISPR field and will provide $LCTX an option to obtain an exclusive license to utilize & sublicense $ERNA novel #GeneEditing cell lines for #preclinical, #clinical, & commercial purposes in the field of CNS diseases.
1/14 #Men and #women experience disease differently. This is reminiscent of #SyndromeX and other chronic disease like #MECFS, #slow #virus manifestations, and even #LongCovid and post-acute sequelae of #SARSCoV2.
A thread summary article 🧵
anu.edu.au/news/all-news/….
A thread summary article 🧵
anu.edu.au/news/all-news/….
2/14 "#Women are up to 75 per cent more likely to experience #adverse #reactions to #prescription #drugs than #men because of a range of differences in #traits between the #sexes, according to a new study from The #Australian #National #University (#ANU)."
3/14 "The researchers believe more should be done to take this into account when treating #diseases."
Our first paper authors.elsevier.com/a/1cRqD6tu0Cbo… is now out @CellStemCell! With @ionispharma & the Jamieson Lab @UCSanDiegoDRM, we found that selective #antisense oligonucleotides inhibiting #IRF4 reduce disease burden & #multiplemyeloma #regeneration in #cancer models. @CellPressNews 1/
IRF4 (interferon regulatory factor 4) is a key plasma cell transcription factor that is known to play a critical role in #myeloma progression. It's been shown to activate networks of #cellcycle and cancer regulators, including the notorious #cancer and #stemcell gene, #MYC. 2/
In this new work, the talented @PhoebeMondala & @AshniVora first dug deeper into the IRF4 networks activated in high-risk forms of #myeloma, including #plasmacellleukemia. IRF4 target genes (SLAMF7, BCMA) were widely induced, especially among genes regulating the #cellcycle. 3/
Our new paper in paper in blood 🩸 and CSF p-tau in #preclinical #Alzheimers 🧠 is out in @EmboMolMed ‼️
A great collaboration between #BarcelonaBeta @fpmaragall and @goteborgsuni
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embopress.org/doi/full/10.15…
A great collaboration between #BarcelonaBeta @fpmaragall and @goteborgsuni
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embopress.org/doi/full/10.15…
A collaboration between great scientists!
@TommyKakari @NicholasAshton @Marta_Mila_ @JuandoGispert @gesalbla @CarolinaMingui2 @ArenazaEider @GSBenavides and all the team of #BarcelonaBeta and the Blennow/Zetterberg lab in @goteborgsuni
A summary below
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@TommyKakari @NicholasAshton @Marta_Mila_ @JuandoGispert @gesalbla @CarolinaMingui2 @ArenazaEider @GSBenavides and all the team of #BarcelonaBeta and the Blennow/Zetterberg lab in @goteborgsuni
A summary below
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We investigated novel CSF and plasma p‐tau biomarkers in the preclinical stage of the Alzheimer’s continuum and compared them with the widely used CSF Mid‐p-tau181.
We hypothesized that they change when subtle changes in Aβ are detectable.
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We hypothesized that they change when subtle changes in Aβ are detectable.
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On #WorldBrainDay, the Neuronet programme is celebrating @IMI_JU's public-private partnerships in #neurodegeneration research; from fundamental science to clinical studies, data analysis to knowledge mining & beyond.
Keep your eyes peeled! #WeAreNeuronet
Keep your eyes peeled! #WeAreNeuronet
2/20 @bwfalcon, now a group leader at @MRC_LMB, worked on the structure of Tau filaments @imprind, showing how they are misfolded in the brains of people with #neurodegenerative diseases.
Read about his work here: bit.ly/IMPRIND-falcon #WorldBrainDay
Read about his work here: bit.ly/IMPRIND-falcon #WorldBrainDay
3/20 #WorldBrainDay 2020 is dedicated to raising awareness of #Parkinsons disease. There are currently no disease-modifying treatments for mild cognitive impairment in PD; the #PD-MIND project aims to test a new drug to treat this condition. Find out more:bit.ly/PD-MIND
