Discover and read the best of Twitter Threads about #Lung

Ivan Zanoni

@Lo_Zanzi

#location location location: thrilled to share our work @CellCellPress! #interferons dictate #COVID19 severity! Specific #IFNs are produced along the #airways in response to #SARSCoV2 and drive protective or detrimental #transcriptional programs! 1/7 doi.org/10.1016/j.cell…

IFNs are driven by high #viral #loads, suggesting that viral recognition is only achieved when #SARSCoV2 reaches a certain threshold! Efficient induction of protective IFNs is preferentially achieved by younger patients, further explaining susceptibility of elders to #COVID19 2/7

#IFNL1 & #IFNL3 characterize mild illness & drive potent anti-#SARSCoV2 #ISGs in the upper #airways. Severe patients show #typeI IFN & #IFNL2 along the respiratory tract but lack ISGs, dampen cell proliferation programs associated to #repair and boost #apoptotic #p53 pathways 3/7

Read 7 tweets

Medical Science and Technology #earlytreatments

@MedicalScitech

🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…

Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.

Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.

Read 213 tweets

Medical Science and Technology #earlytreatments

@MedicalScitech

Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.

🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.

High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others

Read 236 tweets

Medical Science and Technology #earlytreatments

@MedicalScitech

⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.

⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.

⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.

Read 235 tweets

Amy Proal, PhD

@microbeminded2

1/ This excellent study by @aaronmring/@VirusesImmunity and team found that COVID-19 patients exhibit dramatic increases in the production of antibodies against thousands of human extracellular and secreted proteins (the exoproteome) compared to controls 👇

https://twitter.com/virusesimmunity/status/1337574470878449665

2/ The million dollar question is: what molecular mechanisms underly this antibody/#autoantibody production? It is worth interpreting the findings via the lens of human #microbiome/#virome activity + the activity of persistent pathogens (such as EBV) harbored by study subjects.

3/ Every study subject harbored extensive microbiome/virome communities comprised of trillions of organisms during #COVID-19 infection…with such ecosystems now understood to persist beyond just the gut but also in other body sites (#lung, liver etc).

Read 15 tweets

beena sarwar

@beenasarwar

#Thread #COVIDSecondWave
Dire warning from Dr Darayus Gazder, a young doctor in #Karachi: Second wave is very strong, patients are highly critical and sick. We have a waiting list of over 10 per bed. People are dying/suffering alone w no one to say goodbye!
It's painful
1/n

Some deteriorate within minutes. Others who survive COVID have permanent severe #lung damage, can't eat a single meal w/o high flow oxygen, later die painfully as if #drowning once respiratory/cardiac muscles can't compensate as oxygen is depleted.
- Dr Darayus Gazher 2/n

Educated people should take this seriously. But they are Instead throwing parties, weddings, going to sports events, malls, shopping, eating out with no precautions, even mocking the disease. This selfish behaviour must end as it endangers ALL age groups
- Dr Darayus Gazder 3/n

Read 8 tweets

Andrés Hidalgo

@AndrsHidalgo16

How long do #neutrophils live? Are they all equal or do they adapt to tissues?
Get answers to these & more questions in our new paper just out online at @CellCellPress!
Led by our fabulous @AndreaRP88 & @ivanbamartin!
Key points in thread 👇

embargoed.www.cell.com/action/showFul…

Neutrophils are almost ubiquitous in the body. At varying levels, but present in almost every tissue

This is a finding in line with our previous work by @Casanova_Acebes @NicolasAvilaJA & Jackson Li @JExpMed 2018

Read 12 tweets

Abby Philips M.D., D.M. (Hepatology)

@drabbyphilips

So this #Stupidity hits close to home. So a #discussion on #arsenicum album 30.
📌30 means 30 times diluted, standard for #Homeopathy
📌What is #diluted? ➡️ #Arsenic trioxide
📌#homeopath says only 0.443mg of compound per pellet
📌Thats #safety levels right? ➡️ NO.
Read on
2/n

#Arsenic whatever form, concentration, level, is #dangerous #harmful to #humans.
📌Even LOW DOSE intermediate to #long use can lead to #Cancer
📌Actually, many types of #Cancers - #skin, #liver, #bladder, #kidney, #lung
📌Those with #diabetes #heartdisease its #deathwish
👇
3/n

📌NOT one proper #study on this #drug in #Medical #history
📌Read artilce @AltNewsScience debunking fake evidence: bit.ly/2Xra5KY
📌#traditional use was in #diarrhea
📌#pseudoscience at its best
👇 Arsenic is As and not ARS
🔥Even though arsenicum album is #crap
4/n

Read 5 tweets

Lancelot Pinto

@lancelot_pinto

1/4 Saw this at Bandstand today. As a chest physician, this made me very happy! Pigeons are responsible for an interstitial lung disease (ILD) called hypersensitivity pneumonitis or extrinsic allergic alveolitis.

2/4 Most chest physicians and radiologists in the city will tell you how the number of patients with the disease has consistently increased over the years, paralleling the increase in the pigeon population of the city.

3/4 Thank you, whoever was responsible for this, and I hope this awareness increases! #interstitiallungdisease #lunghealth #lung #pigeon #mumbai #bandstand #ild @RajaniSurendarB @bandrabuzz @RupsaChak @AlexandraUlmer

Read 4 tweets

Martin Borch Jensen

@MartinBJensen

[Thread]
Two #ASGCT20 morning sessions focused on lung delivery. Cool work, but it seems to me that the big issues for clinical stage haven't really been addressed:

#AAV can target specific cell types in the lung, and multiple groups have rescued mouse models of genetic diseases. But both new and old lung-trophic capsids seem to hit T2 epithelial cells, which turn over and lose non-integrating transgenes.

Why does the virus end up in these cells? Are the T1 cells designed to reject microbes? What about fibroblasts and other cells, that do get transduced in some tissues?

Read 8 tweets

Francisco Marty, MD

@FranciscoMarty_

#Remdesivir begins distribution in the #USA today via #EUA.

I thought would write down some practical #tips based on my #qualitative anecdotal experience after personally treating close to 200 patients with #COVID19.

For quantitative results, wait for the papers¬—thread

“this juice works, doc!” When you hear similar expressions 1-2 days after starting #remdesivir multiple times, you start to wonder. Don't recall a similar proportion of patients smile after feeling so sick 1-2 days earlier with #COVID19. x/n? Wait for the papers.

Like #treatment for any severe infectious disease (meningitis, Gram-negative bacteremia, influenza pneumonia, etc), earlier is always better. #COVID19 is no different. #Remdesivir stops #SARS-CoV2 replication, but won’t heal the lung injury.

Read 13 tweets

COVID-19 Crisis Town Hall at UC Davis

@CovidTownHall

Starting! @AngelaHaczku is joining us for @ucdavisbiology's #CovidTownHall! Dr. Haczku is a physician & co-author on the paper describing the 1st US community transmission of COVID-19 at @UCDavisHealth (Paper: doi.org/10.1093/cid/ci…). Tune in live: facebook.com/watch/live/?v=…

@AngelaHaczku, M.D., Ph.D., is a Professor of #Medicine, Director of the UC Davis #Lung Center, and is Associate Dean of Translational Research for @UCDavisMed. She is internationally recognized expert in pulmonary immunology. #CovidTownHall #Covid19

@AngelaHaczku's research focuses on the effects of environmental exposures (air pollution, cigarette smoke, psychosocial stress) on respiratory health & disease. She’s authored ~100 peer-reviewed papers, has been federally funded for the past 15 years.
#CovidTownHall #Covid19

Read 30 tweets

Lumos Biotech

@lumosbio

THREAD from the new #bradykinin research (pre-print) from 🇳🇱:

"We propose that the severity of the disease and many deaths are due to a local vascular problem due to activation of B1 receptors on #endothelial cells in the lungs."

#COVID19 #kinins

preprints.org/manuscript/202…

➡️"the B1 receptor on endothelial cells is upregulated by proinflammatory #cytokines

➡️ Without #ACE2 acting as a guardian to inactivate the ligands of B1, the lung environment is prone for local vascular leakage leading to #angioedema"

...

#bradykinin #COVID19

➡️"... and might explain the typical #CTscans and the feeling of people that they drown.

➡️In some pt., this is followed by a clinical worsening of disease around day 9 due to the formation antibodies directed against the spike (S)-antigen of #SARSCoV2 that binds to #ACE2"

Read 12 tweets

VapingIT, SPE, EEI

@Vapingit

Let's journey back on the #FireTheSG movement, shall we?

December 2018, @Surgeon_General @JeromeAdamsMD convinced the public #media, inflating a false "epidemic" w/30-day use, not daily.

Lie #1: vapinglinks.blog/2019/01/06/epi…

Based on feelings, Google alerts, potential & inaccuracy.

No refuting vaping products help smokers quit, 👆above, continues below...

With #data he wanted to present, sentiment and "feelings" continued.

Lie #2: rodutobaccotruth.blogspot.com/2019/11/high-s…

Indifferent, bans & taxes ⏫increasing countrywide, & no care of helping smokers quit.

#FireTheSG

False statements, accusations continued. When corrected, he didn't like that and had to swallow his narrative.

In full, with @2Vaping, @TheLegionCmdr, @Surgeon_General & others:

vapinglinks.blog/2019/02/13/sur…

“If you repeat a lie often enough, it becomes the truth“

#FireTheSG

Read 20 tweets

Andrew Thompson

@vaper_the

A fisking of the opinion piece by Michelle Jongenelis (from the doghouse of @DrOliviaDoll1) in Fairfax media. No public link known (it appeared in a variety of regional newspapers around #Australia).

"THE recent death of a US man who contracted a serious lung disease after taking up #vaping comes as no surprise to many #PublicHealth advocates."
No mention of #BlackMarket, unregulated #cannabinoids, despite 6 US regions involved, explicitly mentioning it.

"Contrary to the messages being disseminated by the vaping industry (an industry now largely owned by #BigTobacco), .."
Wrong! Neither the majority of companies, nor vape sales, involve products ownership by the #TobaccoIndustry.

Read 35 tweets

Melanoma Barbie

@alexshoushtari

Hey #tipsfornewdocs #medtwitter folks! I wanted to review side effects of immune checkpoint inhibitors (ICIs) for a non-#oncology audience. Immune-related adverse events (irAEs) present across all medicine specialties so we are all in this together. 1/x

The most common ICIs are against PD-1 (e.g. nivolumab, pembrolizumab) and PD-L1 (e.g. atezolizumab, durvalumab). I use a blanket term “PD-1” throughout. Anti-CTLA-4 (ipilimumab) is a distant second; often in combo or directly after PD-1 in #melanoma #lung #kidney cancers. 2/x

They have led to pharma riches and Nobel Prizes and lots of TV commercials because they work really well for some patients. People with advanced #melanoma, #lcsm etc who used to live ~1 year now can hope to live for several years or more. 3/x

Read 17 tweets

Discover and read the best of Twitter Threads about #Lung

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Discover and read the best of Twitter Threads about #Lung

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