Discover and read the best of Twitter Threads about #transcriptional

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Ivan Zanoni
@Lo_Zanzi
#location location location: thrilled to share our work @CellCellPress! #interferons dictate #COVID19 severity! Specific #IFNs are produced along the #airways in response to #SARSCoV2 and drive protective or detrimental #transcriptional programs! 1/7 doi.org/10.1016/j.cell…
IFNs are driven by high #viral #loads, suggesting that viral recognition is only achieved when #SARSCoV2 reaches a certain threshold! Efficient induction of protective IFNs is preferentially achieved by younger patients, further explaining susceptibility of elders to #COVID19 2/7
#IFNL1 & #IFNL3 characterize mild illness & drive potent anti-#SARSCoV2 #ISGs in the upper #airways. Severe patients show #typeI IFN & #IFNL2 along the respiratory tract but lack ISGs, dampen cell proliferation programs associated to #repair and boost #apoptotic #p53 pathways 3/7
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#location #reviewers #epithelial #RIG #apoptotic #IFNL1 #typeI #protein #SARSCoV2 #inflammatory #blood #typeIII #editors #IFNs #repair #ISGs #lungs #dsRNA #IFNL2 #viral #interferons #DAMPs #p53 #COVID19

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