Discover and read the best of Twitter Threads about #Pathophysiology
Most recents (15)
Sarcopenia and Cardiovascular Diseases: @CircAHA
From the Geriatric Cardiology Leadership Council: @ACCinTouch
Main congratulations to @Dr_Alfaraidy: a board certified geriatrician and a cardiology fellow - she is amazing AND the best: @ParagGoyalMD 👏
Summary👇👇👇
From the Geriatric Cardiology Leadership Council: @ACCinTouch
Main congratulations to @Dr_Alfaraidy: a board certified geriatrician and a cardiology fellow - she is amazing AND the best: @ParagGoyalMD 👏
Summary👇👇👇
1/ 🚨 Sarcopenia is the loss of muscle strength, mass & function, worsened by chronic illness like CVD, kidney disease, & cancer 😷🩺
2/ 👴👵 Older adults face higher risks: faster CVD progression, mortality, falls, & reduced quality of life 📉
#MiniTweetorial #Part1 on #RVFailure based on the @NEJM paper by @RyanTedfordMD @Brian_Houston12 !
A must read for all cardiology #ACCFIT fellows and @ACPIMPhysicians residents!
nejm.org/doi/pdf/10.105…
Let's begin !
Part 1 - Mechanisms of RV failure
A must read for all cardiology #ACCFIT fellows and @ACPIMPhysicians residents!
nejm.org/doi/pdf/10.105…
Let's begin !
Part 1 - Mechanisms of RV failure
Let's get started with a poll.
Do you know the various mechanisms of RV failure?
Do you know the various mechanisms of RV failure?
#1 #Pathophysiology
4 Mechanical Mechanisms➡️ >1 can co-exist and are interconnected :
✅Increased preload
✅Increased afterload
✅Decreased contractility
✅Decreased lucitropy
4 Mechanical Mechanisms➡️ >1 can co-exist and are interconnected :
✅Increased preload
✅Increased afterload
✅Decreased contractility
✅Decreased lucitropy
Bench to bedside series: Lung COPD part 1/3
Respiratory histology (via @drawittoknowit)
Health & COPD Lung @TheLancet
#4KMedEd #meded #foamed #medtwitter #MedEd #MedTwitter #Pulmtwitter #scRNAseq #Bioinformatics
Respiratory histology (via @drawittoknowit)
Health & COPD Lung @TheLancet
#4KMedEd #meded #foamed #medtwitter #MedEd #MedTwitter #Pulmtwitter #scRNAseq #Bioinformatics
Bench to bedside series: Lung COPD part 2/3
2. #Pathophysiology of #COPD via @EricWong_MD
#4KMedEd #meded #foamed #medtwitter #MedEd #MedTwitter #Pulmtwitter #scRNAseq #Bioinformatics
2. #Pathophysiology of #COPD via @EricWong_MD
#4KMedEd #meded #foamed #medtwitter #MedEd #MedTwitter #Pulmtwitter #scRNAseq #Bioinformatics
Bench to bedside series: Lung COPD part 3/3
#scRNAseq paper: Human distal airways contain a multipotent secretory cell that can regenerate alveoli
1. RASCs (new cell-type) + #stemcell properties in distal airways 2. faulty RASC-to-AT2 transformation in COPD
#Bioinformatics #MedEd
#scRNAseq paper: Human distal airways contain a multipotent secretory cell that can regenerate alveoli
1. RASCs (new cell-type) + #stemcell properties in distal airways 2. faulty RASC-to-AT2 transformation in COPD
#Bioinformatics #MedEd
Healthy Lung vs. Lung with Chronic Obstructive Pulmonary Disease (COPD)
h/t @PatologCritica
#4KMedEd #meded #foamed #medtwitter #MedEd #MedTwitter #Pulmtwitter #lung #COPD #INNOMed
h/t @PatologCritica
#4KMedEd #meded #foamed #medtwitter #MedEd #MedTwitter #Pulmtwitter #lung #COPD #INNOMed
Bench to bedside series: Lung COPD part 1/3
Respiratory histology (via @drawittoknowit)
Health & COPD Lung @TheLancet
#4KMedEd #meded #foamed #medtwitter #MedEd #MedTwitter #Pulmtwitter #scRNAseq #Bioinformatics
Respiratory histology (via @drawittoknowit)
Health & COPD Lung @TheLancet
#4KMedEd #meded #foamed #medtwitter #MedEd #MedTwitter #Pulmtwitter #scRNAseq #Bioinformatics
Bench to bedside series: Lung COPD part 2/3
2. #Pathophysiology of #COPD via @EricWong_MD
#4KMedEd #meded #foamed #medtwitter #MedEd #MedTwitter #Pulmtwitter #scRNAseq #Bioinformatics
2. #Pathophysiology of #COPD via @EricWong_MD
#4KMedEd #meded #foamed #medtwitter #MedEd #MedTwitter #Pulmtwitter #scRNAseq #Bioinformatics
1) Welcome to a new #accredited #tweetorial on #hypertrophic #cardiomyopathy #HCM. Our expert author is Ahmad Masri MD @MasriAhmadMD of @OHSUCardio where he leads the Hypertrophic Cardiomyopathy Ctr. See a previous program from him, on #Fabry disease, at cardiometabolic-ce.com/cardiorenal-fa….
2a) This program is intended for #healthcare providers and is supported by an educational grant from Bristol-Myers Squibb. Statement of accreditation and faculty disclosures at cardiometabolic-ce.com/disclosures/. FOLLOW US for the most timely expert education in #cardiometabolic care!
2b) #Physicians #Nurses #PhysicianAssociates #NursePractitioners #Pharmacists earn a full 1⃣ hour of 🆓CE/#CME credit from following this 🧵. For educational purposes, Twitter still works!! 😁
Though not its intention, this study from #OW2022 illustrated the concepts of satiation vs satiety very well
Colloquially we use these terms interchangeable
But they are technically different
#obesity #science #research #physiology #pathophysiology
#weight
1/
Colloquially we use these terms interchangeable
But they are technically different
#obesity #science #research #physiology #pathophysiology
#weight
1/
Satiation is the feeling of fullness WITHIN a meal while satiety is the feeling of fullness IN BETWEEN meals
Even though current meds like GLP1s seem to affect both, it’s an impt distinction especially when some peptides (eg, amylin)
Even though current meds like GLP1s seem to affect both, it’s an impt distinction especially when some peptides (eg, amylin)
may only effect satiation (⬇️meal size) and not satiety (change meal frequency)
[btw This study was an intracerebral injection of calcitonin into male rats and calcitonin is an agonist at the amylin receptor in the ventral tegmental area]
[btw This study was an intracerebral injection of calcitonin into male rats and calcitonin is an agonist at the amylin receptor in the ventral tegmental area]
Bench to bed series: Lung COPD part 1/3
1. #Respiratory #histology (via @drawittoknowit)
#4KMedEd #meded #foamed #medtwitter #MedEd #MedTwitter #Pulmtwitter #scRNAseq #Bioinformatics
1. #Respiratory #histology (via @drawittoknowit)
#4KMedEd #meded #foamed #medtwitter #MedEd #MedTwitter #Pulmtwitter #scRNAseq #Bioinformatics
Bench to bed series: Lung COPD part 2/3
2. #Pathophysiology of #COPD via @EricWong_MD
#4KMedEd #meded #foamed #medtwitter #MedEd #MedTwitter #Pulmtwitter #scRNAseq #Bioinformatics
2. #Pathophysiology of #COPD via @EricWong_MD
#4KMedEd #meded #foamed #medtwitter #MedEd #MedTwitter #Pulmtwitter #scRNAseq #Bioinformatics
Bench to bed series: Lung COPD part 3/3
#scRNAseq paper: Human distal airways contain a multipotent secretory cell that can regenerate alveoli
1. RASCs (new cell-type) + #stemcell properties in distal airways 2. faulty RASC-to-AT2 transformation in COPD
#Bioinformatics #meded
#scRNAseq paper: Human distal airways contain a multipotent secretory cell that can regenerate alveoli
1. RASCs (new cell-type) + #stemcell properties in distal airways 2. faulty RASC-to-AT2 transformation in COPD
#Bioinformatics #meded
1) Welcome to a new #accredited #tweetorial on Clinical and Laboratory Manifestations of #DKD in #T2D: From Early Identification to Monitoring Management. Your expert author is @edgarvlermamd.
2a) This activity is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers. It is accredited for #physicians #physicianassistants #nurses #NPs #pharmacists. Check out @cardiomet_ce for more🆓CE/#CME.
2b) Past programs are still eligible for credit & can be found at cardiometabolic-ce.com. Faculty disclosures are at cardiometabolic-ce.com/disclosures/.
#FOAMed #medtwitter #diabetesmanagement #kidneydisease #diabetickidneydisease #diabetes @goKDIGO @MedTweetorials @nephondemand
#FOAMed #medtwitter #diabetesmanagement #kidneydisease #diabetickidneydisease #diabetes @goKDIGO @MedTweetorials @nephondemand
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
Proposed COVID-19 Pathophysiology [Part 3 of (now) 4]:
Coagulopathy Strikes Back.
What happens when #COVID19 clashes with the world of hematology?
Buckle up again for a long one.
...let’s dive in like this macrophage (exploring all directions):
Coagulopathy Strikes Back.
What happens when #COVID19 clashes with the world of hematology?
Buckle up again for a long one.
...let’s dive in like this macrophage (exploring all directions):
First, what do you think is the predominant mechanism by which thrombosis occurs in COVID-19?
Where does thrombosis typically first occur?
Proposed COVID-19 Pathophysiology [Part 2 of 3]:
Enter the magnificent macrophage.
What do #COVID-19 and hemophagocytic lymphohistiocytosis (#HLH) potentially have in common?
...let’s continue our journey onward into the cytokine storm.
Enter the magnificent macrophage.
What do #COVID-19 and hemophagocytic lymphohistiocytosis (#HLH) potentially have in common?
...let’s continue our journey onward into the cytokine storm.
First, let’s briefly summarize what we covered before:
What mechanism may be partly responsible for heterogeneity of COVID-19 disease phenotype as well as its severity?
What mechanism may be partly responsible for heterogeneity of COVID-19 disease phenotype as well as its severity?
Correct! Antibody-dependent enhancement (ADE) is the result of producing sub-neutralizing antibodies which paradoxically enhance the rate of viral replication and severity of viremia.
Proposed COVID-19 Pathophysiology [Part 1 of 3]
What do #COVID-19 and #Dengue fever potentially have in common?
The answers have significant potential clinical implications in COVID-19.
Buckle up. It's a long one.
Let’s take a hematological walk on the zoonotic side.
What do #COVID-19 and #Dengue fever potentially have in common?
The answers have significant potential clinical implications in COVID-19.
Buckle up. It's a long one.
Let’s take a hematological walk on the zoonotic side.
Dengue is a flavivirus that is called “breakbone fever”, a nod to bone-breaking pains that occur during the infection.
There are four serotypes of the dengue virus.
Infection with one serotype does not fully protect one from contracting a different serotype.
There are four serotypes of the dengue virus.
Infection with one serotype does not fully protect one from contracting a different serotype.
True or false: The second or later infection with dengue is often much more dangerous.
The Tale of the Low Chloride
Once there was 34 year old man who used marijuana and was 🤮nauseous, vomitting, and confused. The resident 📞calls and says, "All the electrolytes are abnormal!! Can you help?"
renalfellow.org/2019/12/16/ske…
@TheSkeletonKG #FOAMED #medtwitter #tweetorial
Once there was 34 year old man who used marijuana and was 🤮nauseous, vomitting, and confused. The resident 📞calls and says, "All the electrolytes are abnormal!! Can you help?"
renalfellow.org/2019/12/16/ske…
@TheSkeletonKG #FOAMED #medtwitter #tweetorial
You say of course and see the patient. 🥼🩺His BP was 131/87 mmHg with a HR of 142 bpm. He was fatigued, but AOx3. Moist mucous membranes, normal skin turgor, and no LE edema.
💉Labs are shown and reveal a serum osmolality of 263 with ALL normal labs 3 months prior.
💉Labs are shown and reveal a serum osmolality of 263 with ALL normal labs 3 months prior.
Loving Nephrology🤓, you ask, "What about the urine?!"
He is making urine with a urine Cl of < 20.
(💭Learn more about FeK and Urine K/Cr ratio with our previous case! renalfellow.org/2019/11/14/the… @hotsaltrocks )
He is making urine with a urine Cl of < 20.
(💭Learn more about FeK and Urine K/Cr ratio with our previous case! renalfellow.org/2019/11/14/the… @hotsaltrocks )
