Discover and read the best of Twitter Threads about #angioedema
Most recents (6)
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1/As promised & after reading $NTLA latest Q1 2022 financial report here is my analysis regarding @intelliatx latest corporate status. I have focused only on the main issues that I found to be the most interesting & relevant. #CRISPR #GeneEditing #BioTech #FinTwit #Genomics👇
2/NTLA-2001 is the most advanced In-Vivo #CRISPR/#Cas9 #GeneEditing program in $NTLA portfolio & is aimed to treat Transthyretin Amyloidosis - (ATTR). NTLA-2001 could potentially halt & reverse the disease in a “one time” treatment by knocking out the TTR gene with a single dose
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1/🧵 Let’s learn about Ace inh-induced angioedema
His lips & tongue swelled up hours after taking a blood pressure med he’d been on 10 years - lisinopril.
📍What’s the treatment?
📍Is it an allergy?
📍What’s a common thought error?
(Pic w Perm - trigger warning tweets 2 & 4)
His lips & tongue swelled up hours after taking a blood pressure med he’d been on 10 years - lisinopril.
📍What’s the treatment?
📍Is it an allergy?
📍What’s a common thought error?
(Pic w Perm - trigger warning tweets 2 & 4)
2/ Angioedema is potentially life-threatening
It’s very scary to see the tongue & lips swelling up so much and the airway compromised.
The patients are watched in the ICU so that intubation and even tracheostomy can occur emergently if required.
What’s the Dz Mechanism?
It’s very scary to see the tongue & lips swelling up so much and the airway compromised.
The patients are watched in the ICU so that intubation and even tracheostomy can occur emergently if required.
What’s the Dz Mechanism?
3/ Is ACE-inh induced Angioedema an allergy?
NO! It’s not an IGE mediated allergic reaction.
💥 Pro Tip:
People can get angioedema from allergies, but they would be very itchy, and my patient was not itching at all.
That's because it's mediated by a buildup of bradykinin.
NO! It’s not an IGE mediated allergic reaction.
💥 Pro Tip:
People can get angioedema from allergies, but they would be very itchy, and my patient was not itching at all.
That's because it's mediated by a buildup of bradykinin.
⭐️FIVE Little Allergy/Immunology Lessons from 5 Big Days on Consults ⭐️ @mghaifellows @MGHAllergy. #Urticaria #Angioedema #vaccine reactions eosinophilia and #drugallergy /1
ONE-To treat acute urticaria (hives), antihistamines should be nonsedating and scheduled (not diphenhydramine PRN). Allegra/fexofenadine and Zyrtec/cetirizine have large therapeutic windows and are used safely at 4+ times the daily allergic rhinitis dose/2
TWO-Angioedema in an adult without skin itching/hives/rash—check if they on an ACE inhibitor! Although ~10% get it w/in 30d, many happen after years of uneventfully being on it /3 ncbi.nlm.nih.gov/pmc/articles/P…
While on the topic on #Angioedema with @EMBoardBombs
It was mentioned about tPA causing angioedema. It is scary and happened to me. I didn't know about it until it happened to me.
Follow along for a short #medtweetorial case report with some tips. ncbi.nlm.nih.gov/pmc/articles/P…
It was mentioned about tPA causing angioedema. It is scary and happened to me. I didn't know about it until it happened to me.
Follow along for a short #medtweetorial case report with some tips. ncbi.nlm.nih.gov/pmc/articles/P…
The most dreaded adverse effect of tPA, hemorrhagic conversion of an ischemic stroke.
But there is another scary, unusual & potentially life-threatening adverse effect of tPA. ANGIOEDEMA
It usually affects the side of the tongue ipsilateral to the stroke.
But there is another scary, unusual & potentially life-threatening adverse effect of tPA. ANGIOEDEMA
It usually affects the side of the tongue ipsilateral to the stroke.
The patient in the picture presented with left side weakness/facial droop and his stroke was on the right brain. Hence the left-sided tongue swelling.
What is Angioedema?
It is an acute well-demarcated swelling involving the deeper layers of skin of the skin.
What is Angioedema?
It is an acute well-demarcated swelling involving the deeper layers of skin of the skin.
THREAD from the new #bradykinin research (pre-print) from 🇳🇱:
"We propose that the severity of the disease and many deaths are due to a local vascular problem due to activation of B1 receptors on #endothelial cells in the lungs."
#COVID19 #kinins
preprints.org/manuscript/202…
"We propose that the severity of the disease and many deaths are due to a local vascular problem due to activation of B1 receptors on #endothelial cells in the lungs."
#COVID19 #kinins
preprints.org/manuscript/202…
➡️"the B1 receptor on endothelial cells is upregulated by proinflammatory #cytokines
➡️ Without #ACE2 acting as a guardian to inactivate the ligands of B1, the lung environment is prone for local vascular leakage leading to #angioedema"
...
#bradykinin #COVID19
➡️ Without #ACE2 acting as a guardian to inactivate the ligands of B1, the lung environment is prone for local vascular leakage leading to #angioedema"
...
#bradykinin #COVID19
