Discover and read the best of Twitter Threads about #endothelial
Most recents (8)
#WeekendLecture
#GeneticsAndStroke
#Genetics is involved in several #stroke related conditions, such as small vessel disease #SVD, aneurysms, dissections, cavernomas, and intracranial #hemorrhages
Check this 🧵!
Prepared by @J_Rosales_MD
Edited by @interneurona
#GeneticsAndStroke
#Genetics is involved in several #stroke related conditions, such as small vessel disease #SVD, aneurysms, dissections, cavernomas, and intracranial #hemorrhages
Check this 🧵!
Prepared by @J_Rosales_MD
Edited by @interneurona
#Weekendlecture
#Genetic & #SVD
🧬🧠
✅1,5% of cerebral #SVD are #monogenic disorders
✅AR, AD or X-linked
☝🏼Absence of family history doesn't rule out diagnosis because of
👉de novo mutation
👉reduced expression or
👉incomplete penetrance
✅ahajournals.org/doi/10.1161/ST…
#Genetic & #SVD
🧬🧠
✅1,5% of cerebral #SVD are #monogenic disorders
✅AR, AD or X-linked
☝🏼Absence of family history doesn't rule out diagnosis because of
👉de novo mutation
👉reduced expression or
👉incomplete penetrance
✅ahajournals.org/doi/10.1161/ST…
#Weekendlecture
#Genetic & #SVD
When to #suspect?🕵️♀️
✅early onset stroke without vascular RFs
✅systemic features and neuroimaging of an specific monogenic disorder
✅consanguinity
✅negative work up for other causes of SVD
👉ahajournals.org/doi/10.1161/ST…
#Genetic & #SVD
When to #suspect?🕵️♀️
✅early onset stroke without vascular RFs
✅systemic features and neuroimaging of an specific monogenic disorder
✅consanguinity
✅negative work up for other causes of SVD
👉ahajournals.org/doi/10.1161/ST…
We know that the two Ad-vector based vaccines, #AstraZeneca & #JNJ lead to clot-related complications like cerebral venous sinus thrombosis. We also know these events are referred to as ‘Vaccine induced Thrombotic Thrombocytopenia’ (VITT). But what lead to these complications? 1/
Now a new explanation for VITT seen with vector vaccines. “Vaccine-Induced #Covid19 Mimicry” Syndrome: Splice reactions within the #SARSCoV2 Spike ORF result in ‘Spike protein variants’ that may cause thromboembolic events in patients immunized with vector-based vaccines 2/
These soluble Spike #variants may initiate severe side effects when binding to #ACE2-expressing #endothelial cells in blood vessels 3/
Endothelial-derived microvesicles play a pathogenic role in vascular #inflammation, causing #endothelial barrier dysfunction by impairing adherens junctions and activating #neutrophils
More here: bit.ly/3g1FpH7
#Cardiotwitter #CardiovascularResearch
#Tweetorial below!
More here: bit.ly/3g1FpH7
#Cardiotwitter #CardiovascularResearch
#Tweetorial below!
#Microvesicles (MV) are formed from the outward blebbing of the plasma membrane and carry a diverse cargo that regulate multiple processes.
During #inflammation these are produced by activated endothelial cells and released into the #circulation. TEM image of plasma MVs: (2/8)
During #inflammation these are produced by activated endothelial cells and released into the #circulation. TEM image of plasma MVs: (2/8)
THREAD from the new #bradykinin research (pre-print) from 🇳🇱:
"We propose that the severity of the disease and many deaths are due to a local vascular problem due to activation of B1 receptors on #endothelial cells in the lungs."
#COVID19 #kinins
preprints.org/manuscript/202…
"We propose that the severity of the disease and many deaths are due to a local vascular problem due to activation of B1 receptors on #endothelial cells in the lungs."
#COVID19 #kinins
preprints.org/manuscript/202…
➡️"the B1 receptor on endothelial cells is upregulated by proinflammatory #cytokines
➡️ Without #ACE2 acting as a guardian to inactivate the ligands of B1, the lung environment is prone for local vascular leakage leading to #angioedema"
...
#bradykinin #COVID19
➡️ Without #ACE2 acting as a guardian to inactivate the ligands of B1, the lung environment is prone for local vascular leakage leading to #angioedema"
...
#bradykinin #COVID19
Dermatologist are seeing more and more #skin symptoms related to #COVID19 . Acral lesions (i.e. hands and feet) are particularly frequent, specially in #children and #youngadult with no or few COVID symptoms. After seeing many cases, here is my vision: #Thread 👇
I think that these kind of lesions can be classified in four types. 1. Chilblain-like lesions, which are the most described, usually affecting many fingers / toes, either symmetrically or not. Pruritic and/or painful.
2. Insect-bite like lesions, that may also appear in the palm and the soles. Very #itchy and persistent (more than 2 weeks in some cases)
Sub-study of WISE @JACCJournals by @ahmedalbadrimd @lesleejshaw:
In women with signs & symptoms of ischemia
✅ low CFR (microvascular dysfunction) ➡️ ⬆️ major CV events
✅ endothelial dysfunction ➡️ ⬆️ angina hospitalization
onlinejacc.org/content/73/6/6…
@emorywomenheart @venkmurthy
In women with signs & symptoms of ischemia
✅ low CFR (microvascular dysfunction) ➡️ ⬆️ major CV events
✅ endothelial dysfunction ➡️ ⬆️ angina hospitalization
onlinejacc.org/content/73/6/6…
@emorywomenheart @venkmurthy
In this relatively large & very well-done study, 4 indices of coronary dz were invasively measured:
✅ CFR (adenosine): non-endo dependent CMD
✅ CBF (ACh): endo dependent CMD
✅ Nitro Δ CSA: non-endo dependent epicardial dz
✅ ACh Δ CSA: endo depedent epicardial dz
✅ CFR (adenosine): non-endo dependent CMD
✅ CBF (ACh): endo dependent CMD
✅ Nitro Δ CSA: non-endo dependent epicardial dz
✅ ACh Δ CSA: endo depedent epicardial dz
Findings:
1️⃣ low CFR associated with ⬆️ MACE
2️⃣ low CBF not associated with MACE
3️⃣ impaired ACh dilatation assocaited with ⬆️ angina hospitalization
4️⃣ impaired NTG dilatation not associated with MACE
@ahmedalbadrimd @lesleejshaw @gina_lundberg @CedarsSinai @Michel_CorbanMD
1️⃣ low CFR associated with ⬆️ MACE
2️⃣ low CBF not associated with MACE
3️⃣ impaired ACh dilatation assocaited with ⬆️ angina hospitalization
4️⃣ impaired NTG dilatation not associated with MACE
@ahmedalbadrimd @lesleejshaw @gina_lundberg @CedarsSinai @Michel_CorbanMD
What’s Your “Shear Stress”?
Want to Know More?
Relax & Read ⤵️ #Tweetorial by @CoronaryDoc + @arnavkumar
⚡️Coronary Wall Shear Stress in 12 Tweets ⚡️
1/12
Main Readings:
1) interventions.onlinejacc.org/content/early/…
2) ow.ly/XmD130mc9X8
3) link.springer.com/article/10.100…
#ACCImaging @ACCCardioEd
Want to Know More?
Relax & Read ⤵️ #Tweetorial by @CoronaryDoc + @arnavkumar
⚡️Coronary Wall Shear Stress in 12 Tweets ⚡️
1/12
Main Readings:
1) interventions.onlinejacc.org/content/early/…
2) ow.ly/XmD130mc9X8
3) link.springer.com/article/10.100…
#ACCImaging @ACCCardioEd
2/12
Wall shear stress (#WSS) is the frictional force of blood exerted tangential to endothelial surface of vessel wall & expressed in variety of units (1Pa=1N/m2=10 dynes/cm2)
It is derived from
• luminal geometry
• flow rate
• blood viscosity
• near wall velocity values
Wall shear stress (#WSS) is the frictional force of blood exerted tangential to endothelial surface of vessel wall & expressed in variety of units (1Pa=1N/m2=10 dynes/cm2)
It is derived from
• luminal geometry
• flow rate
• blood viscosity
• near wall velocity values
3/12
In vivo WSS calculations are derived from computational fluid dynamic (#CFD) simulations created from reconstructed 3D vessel geometries (from biplane angio/IVUS/OCT/CT/MR) combined with patient-specific pulsatile inlet/outlet velocity values (Doppler wire or other methods)
In vivo WSS calculations are derived from computational fluid dynamic (#CFD) simulations created from reconstructed 3D vessel geometries (from biplane angio/IVUS/OCT/CT/MR) combined with patient-specific pulsatile inlet/outlet velocity values (Doppler wire or other methods)
#Coronary Shear Stress & #Endothelial Dysfunction:
Final Piece of #Atherosclerosis & Local #Hemodynamic Puzzle Just Published @jacc
from our @emoryheart & @BME_GT_Emory: @arnavkumar @Michel_CorbanMD @habib_samady @emorywomenheart
interventions.onlinejacc.org/content/early/…
Final Piece of #Atherosclerosis & Local #Hemodynamic Puzzle Just Published @jacc
from our @emoryheart & @BME_GT_Emory: @arnavkumar @Michel_CorbanMD @habib_samady @emorywomenheart
interventions.onlinejacc.org/content/early/…
