Discover and read the best of Twitter Threads about #metabolites
Most recents (8)
Divonne-les-Bains : Karin Schneider, l'insolente qui fait du vin ...
Elle réfléchit déjà au vin qu'elle veut faire l'année prochaine, certainement avec du raisin en culture biologique ou en biodynamique. latribunerepublicaine.fr/43801/article/… #biodynamie
Elle réfléchit déjà au vin qu'elle veut faire l'année prochaine, certainement avec du raisin en culture biologique ou en biodynamique. latribunerepublicaine.fr/43801/article/… #biodynamie
Le Hofgut Rengoldshausen célèbre 800 ans de ferme et 90 ans d'agriculture biodynamique. Depuis la fondation au XIIIe siècle, une ferme progressiste s'est développée et les femmes sont toujours influentes. #Biodynamique
suedkurier.de/region/bodense…
suedkurier.de/region/bodense…
Château d’Estoublon: le jardin provençal du couple Bruni-Sarkozy Depuis longtemps conduite en agriculture biologique, les vignes se voient appliquer les principes de la biodynamie depuis quelques années. terredevins.com/actualites/cha… 
Alors, avant de vous faire bourrer le mou par mes amis @coquelicots_ un petit mot sur les #metabolites de #pesticides, je ne met pas volontairement d'* car cela concerne aussi les #pesticides #bio
voila le lien vers le document guide pour les évaluer ec.europa.eu/food/sites/foo…
je l'appellerai 221/2000 par la suite. Donc cela fait bien depuis les années 2000 qu'ils sont étudiés et évalués. Ce sont les #metabolites retrouvés dans les eaux souterraines
je l'appellerai 221/2000 par la suite. Donc cela fait bien depuis les années 2000 qu'ils sont étudiés et évalués. Ce sont les #metabolites retrouvés dans les eaux souterraines
donc de boisson potentiellement. Donc dans l'eau du robinet. Bon heureusement que les #pesticides se décomposent en métabolites, sinon on en retrouverait partout et ça serait vraiment un problème.
Donc on étudie toutes les transformations
Donc on étudie toutes les transformations
Important #autism article 👉 Pulls together literature showing oral #microbiome dysbiosis in patients w/ the disorder, and explains how activity of certain oral communities/pathogens can dysregulate both gut + brain signaling to drive cognitive symptoms: ncbi.nlm.nih.gov/pmc/articles/P…
2/ Key are sections explaining how “oral #bacteria can find their way to the #brain through a number of pathways following routine #dental procedures”....and sections detailing how #metabolites created by oral bacteria can directly impact brain function 👇
3/ It’s worth noting that dominant oral #pathogen p. gingivalis - and the gingipain proteins it creates to drive inflammation - have now been identified in both #Alzheimer’s brain tissue (ncbi.nlm.nih.gov/m/pubmed/30746…) and in Parkinson’s blood (ncbi.nlm.nih.gov/pmc/articles/P…) 👇
Cool history in this article 👉 But, IMO, #immunology will not “come of age” until it becomes common practice to study the human #immune response in concert w/ the genetic + metabolic activity of the body’s microbial/viral ecosystems
For example, we should study T cell #immunotherapies in concert with the activity of #tumor-associated microbiomes☝️ This study is a good example of how that trend has potential: cancerdiscovery.aacrjournals.org/content/early/…
We also now realize that billions (trillions?) of #phages persist in human tissue/blood 👉 And certain phages can modulate innate #immunity via phagocytosis and cytokine responses..+ adaptive immunity via effects on antibody production: ncbi.nlm.nih.gov/m/pubmed/30585…
Yes 👉 And when #bacteria enter the #blood, they are even more likely to infect + persist inside the cells of the immune system 👉 There, the proteins + #metabolites they create can directly modulate the activity of human genes that regulate #metabolism + immune response etc
Also a growing # of organisms can persist in the #blood itself 👉 This @StanfordMed study found 1000s of never before discovered bacteria + #viruses in the blood of immunocompromised patients (99% of microbes identified were previously unknown to science): pnas.org/content/early/…
A team has grown functioning human #blood vessels in the lab (to help study stroke/#diabetes etc)👇 A truly impressive feat, but I’m worried this model system will not contain the organisms + #microbe/derived metabolites naturally present in human blood?: google.com/amp/s/www.the-…
For example, in this seminal study, @kadzuis and team demonstrated a significant effect of the gut #microbiome on mammalian blood metabolites (in germ-free mice): pnas.org/content/106/10…
Or, this study identified novel associations b/t gut microbiota and fasting serum (#blood) levels of many #metabolites: fatty acids, amino acids, lipids + glucose☝️metabolites that can influence metabolic + cardiovascular disease traits: genomebiology.biomedcentral.com/articles/10.11…
THIS 👉 While the authors frame their findings in a postitive light, the primary mechanism described below (molecular #mimicry b/t #microbial + host signaling molecules) 👉 is also a central mechanism by which organisms can dysregulate host #metabolism in chronic disease
Bacteria in the study create #ligands very similar in size/shape to human ligands that control human GPCR receptor signaling 👉 if such #bacteria change their activity due to #dysbiosis/immunosuppression☝️the ligands they create may begin to dysregulate GPCR receptor signaling
To better understand what I’m talking about read the following sections of my latest paper👇Although the paper focuses on the illness #ME/CFS 👉what I explain about molecular mimicry b/t #microbial + host #metabolites/proteins pertains to many conditions: frontiersin.org/articles/10.33…
Paper proposes that changes to the maternal gut #microbiome during #pregnancy alter levels of microbial #metabolites (including neurotransmitters + neuropeptides)👉 If these metabolites cross the placental barrier, they may impact fetal #brain development:ncbi.nlm.nih.gov/pmc/articles/P…
It follows that gut #microbiome dysbiosis in the mother may change how #microbial metabolites regulate + prime infant #microglia and other neuroimmune cells 👉 This dysregulation may contribute to the development of neurodevelopmental disorders including #autism:
Quote from paper 👉 “We address an emerging #hypothesis behind neurodevelopmental disorders, which implicates #microbiome dysbiosis in the atypical programming of neuroimmune cells, namely microglia”: ncbi.nlm.nih.gov/pmc/articles/P…
