Discover and read the best of Twitter Threads about #ligands
Most recents (3)
Daily Bookmarks to GAVNet 11/09/2021 greeneracresvaluenetwork.wordpress.com/2021/11/09/dai…
The shifting sands of ‘gain-of-function’ research
nature.com/articles/d4158…
#GainOfFunction #ResearchMethodology #ethics #narrative #consequences
nature.com/articles/d4158…
#GainOfFunction #ResearchMethodology #ethics #narrative #consequences
Structure of a ‘promiscuous’ protein will help scientists design better drugs
phys.org/news/2021-11-p…
#GutProtein #MolecularStructure #DrugDevelopment #DrugAbsorption #ResearchResults
phys.org/news/2021-11-p…
#GutProtein #MolecularStructure #DrugDevelopment #DrugAbsorption #ResearchResults
#SciTwitter Does anyone know how often #receptors or #ligands are the limiting factor for in vivo signaling pathways? Versus equilibrium where modulating either side even a little affects activity.
@keiser_lab @kevansf @srikosuri
@keiser_lab @kevansf @srikosuri
For posterity: As far as I can tell so far, when receptors are expressed constitutively at decent levels, ligands are usually limiting. Receptors that are conditionally expressed are usually limiting. Haven't figured out how hard 'limiting' applies in either case.
This is from conversations rather than primary research, so #CaveatEmptor.
THIS 👉 While the authors frame their findings in a postitive light, the primary mechanism described below (molecular #mimicry b/t #microbial + host signaling molecules) 👉 is also a central mechanism by which organisms can dysregulate host #metabolism in chronic disease
Bacteria in the study create #ligands very similar in size/shape to human ligands that control human GPCR receptor signaling 👉 if such #bacteria change their activity due to #dysbiosis/immunosuppression☝️the ligands they create may begin to dysregulate GPCR receptor signaling 
To better understand what I’m talking about read the following sections of my latest paper👇Although the paper focuses on the illness #ME/CFS 👉what I explain about molecular mimicry b/t #microbial + host #metabolites/proteins pertains to many conditions: frontiersin.org/articles/10.33…
