Discover and read the best of Twitter Threads about #mimicry
Most recents (2)
1/4 "Using #PEPMatch, a newly developed #bioinformatics package which predicts #peptide similarity within specific #amino #acid mismatching parameters consistent with published #MHC binding capacity,..."
nature.com/articles/s4159…
nature.com/articles/s4159…
2/4 "... we discovered that #nucleocapsid #protein shares significant overlap with 22 #multiple #sclerosis (#MS)-associated proteins, including #myelin #proteolipid #protein (#PLP).
#MultipleSclerosis
#MultipleSclerosis
3/4 "Further computational evaluation demonstrated that this #overlap may have #critical #implications for #Tcell responses in #multiple #sclerosis (#MS) patients and is likely unique to #SARSCoV2 among the major #human #coronaviruses."
THIS 👉 While the authors frame their findings in a postitive light, the primary mechanism described below (molecular #mimicry b/t #microbial + host signaling molecules) 👉 is also a central mechanism by which organisms can dysregulate host #metabolism in chronic disease
Bacteria in the study create #ligands very similar in size/shape to human ligands that control human GPCR receptor signaling 👉 if such #bacteria change their activity due to #dysbiosis/immunosuppression☝️the ligands they create may begin to dysregulate GPCR receptor signaling 
To better understand what I’m talking about read the following sections of my latest paper👇Although the paper focuses on the illness #ME/CFS 👉what I explain about molecular mimicry b/t #microbial + host #metabolites/proteins pertains to many conditions: frontiersin.org/articles/10.33…
