Discover and read the best of Twitter Threads about #peptide
Most recents (3)
1/4 "Using #PEPMatch, a newly developed #bioinformatics package which predicts #peptide similarity within specific #amino #acid mismatching parameters consistent with published #MHC binding capacity,..."
nature.com/articles/s4159…
nature.com/articles/s4159…
2/4 "... we discovered that #nucleocapsid #protein shares significant overlap with 22 #multiple #sclerosis (#MS)-associated proteins, including #myelin #proteolipid #protein (#PLP).
#MultipleSclerosis
#MultipleSclerosis
3/4 "Further computational evaluation demonstrated that this #overlap may have #critical #implications for #Tcell responses in #multiple #sclerosis (#MS) patients and is likely unique to #SARSCoV2 among the major #human #coronaviruses."
Le #cellule #Car-T “peptide-centriche” contro i #tumori solidi: in questo caso ha come #target i #frammenti proteici nelle cellule di #neuroblastoma. Studio di #Nature riassunto in questo thread un po' lungo ma spero interessante. 1/13 
Le basi/1. Le terapie CAR-T si basano sull’ingegnerizzazione delle #cellule T (o #linfociti T) del sistema #immunitario del #paziente, che vengono “potenziate” per combattere il #tumore. 2/13
Le basi/2. Per farlo gli scienziati usano un #vettore #virale inattivato contenente un #gene in grado di far esprimere sulla superficie delle cellule T un #recettore chimerico (il recettore dell’antigene chimerico, #CAR, a cui la terapia deve il suo nome). 3/13
#SARSCoV2 There are several kinds of #vaccines, whereby all share the goal of generating adaptive #immunity via 1) #antibodies via B cells, and 2) T-cell receptors (#TCRs) via T cells:
1) live-attenuated, where you produce an actual #virus in an egg or cell line
2) #recombinant, where you introduce #DNA into yeast, bacteria, or cell lines — you produce pieces of the #virus #proteins, then either administer them as-is or typically by linking them to immunogenic substrates like albumin, BSA and KLH
