Discover and read the best of Twitter Threads about #recombinant
Most recents (4)
New #PANGO designations - BA.2.*
BA.2.4Alias of B.1.1.529.2.4, #Singapore lineage
BA.2.5Alias of B.1.1.529.2.5, lineage in #Portugal and other countries
BA.2.6Alias of B.1.1.529.2.6, lineage in #France and other countries
BA.2.7Alias of B.1.1.529.2.7, #USA lineage
BA.2.4Alias of B.1.1.529.2.4, #Singapore lineage
BA.2.5Alias of B.1.1.529.2.5, lineage in #Portugal and other countries
BA.2.6Alias of B.1.1.529.2.6, lineage in #France and other countries
BA.2.7Alias of B.1.1.529.2.7, #USA lineage
These are new designations - branching from the BA.2 subvariant
more to follow ..... will update key mutational differences and transmission advantage (if any)
more to follow ..... will update key mutational differences and transmission advantage (if any)
BA.2.4 (aka B.1.1.529.2.4) | prevalent in Singapore
Key mutation: ORF6:M58K
COV-spectrum predicts a growth advantage of 14% over BA.2 and 46% over BA.1.1 in #Singapore
BA.2 and BA.1.1 are currently the dominant lineages in circulation in Singapore
Key mutation: ORF6:M58K
COV-spectrum predicts a growth advantage of 14% over BA.2 and 46% over BA.1.1 in #Singapore
BA.2 and BA.1.1 are currently the dominant lineages in circulation in Singapore
Tracking sequences with both #omicron and #delta signatures
Flagged by @GISAID as "ML" sequence under investigation (#Recombinant or #Contamination ?)
Sequences are under investigation: 4511
Tracker: tinyurl.com/4cbpnz46
Flagged by @GISAID as "ML" sequence under investigation (#Recombinant or #Contamination ?)
Sequences are under investigation: 4511
Tracker: tinyurl.com/4cbpnz46
#USA has 2423 sequences under investigation from multiple laboratories.
They contain signatures from both #Delta and #omicron #variants
ML sequence #hotspots: #California, #Texas, #NewYork, #Arkansas and #Minnesota
#deltamicron or #deltacron or #contamination?
They contain signatures from both #Delta and #omicron #variants
ML sequence #hotspots: #California, #Texas, #NewYork, #Arkansas and #Minnesota
#deltamicron or #deltacron or #contamination?
#India has 568 sequences under investigation from multiple laboratories.
They contain signatures from both #Delta and #omicron #variants
ML sequence #hotspots: #Karnataka, #TamilNadu, #Maharashtra, #Gujarat, #WestBengal, #NewDelhi
#deltamicron/#deltacron or #contamination?
They contain signatures from both #Delta and #omicron #variants
ML sequence #hotspots: #Karnataka, #TamilNadu, #Maharashtra, #Gujarat, #WestBengal, #NewDelhi
#deltamicron/#deltacron or #contamination?
"The live SARS-like coronavirus SL-CoV-WIV1 has been isolated for the first time from bat droppings; and such virus has been confirmed to invade the host cells through the ACE2 of human beings..."
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964
In this study, we have developed a fast and cost-effective method
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily.
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily.
#SARSCoV2 There are several kinds of #vaccines, whereby all share the goal of generating adaptive #immunity via 1) #antibodies via B cells, and 2) T-cell receptors (#TCRs) via T cells:
1) live-attenuated, where you produce an actual #virus in an egg or cell line
2) #recombinant, where you introduce #DNA into yeast, bacteria, or cell lines — you produce pieces of the #virus #proteins, then either administer them as-is or typically by linking them to immunogenic substrates like albumin, BSA and KLH
