Discover and read the best of Twitter Threads about #immunotherapies
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Really chuffed to share our latest work from Sanjana Lab out in @nature today (nature.com/articles/s4158…).
We tested >12,000 genes to find positive regulators of T cell proliferation to be used for next-gen #immunotherapies.
A thread...
We tested >12,000 genes to find positive regulators of T cell proliferation to be used for next-gen #immunotherapies.
A thread...
(2/28) T cell therapies have shown the potential to cure patients from #cancer – but even in B cell cancers, relapses outnumber cures… One of the problems is limited T cell persistence. #celltherapy #CARTcell
(3/28) We wanted to find new genes (including genes never expressed in T cells) that could improve T cell persistence. Now, the question was: should we use #crispr activation or directly deliver target genes on a #lentivirus?
Cool history in this article 👉 But, IMO, #immunology will not “come of age” until it becomes common practice to study the human #immune response in concert w/ the genetic + metabolic activity of the body’s microbial/viral ecosystems
For example, we should study T cell #immunotherapies in concert with the activity of #tumor-associated microbiomes☝️ This study is a good example of how that trend has potential: cancerdiscovery.aacrjournals.org/content/early/…
We also now realize that billions (trillions?) of #phages persist in human tissue/blood 👉 And certain phages can modulate innate #immunity via phagocytosis and cytokine responses..+ adaptive immunity via effects on antibody production: ncbi.nlm.nih.gov/m/pubmed/30585…
