Discover and read the best of Twitter Threads about #StemCells
Most recents (15)
Peer-reviewed paper out today! Our research created induced pluripotent stem cells from bats, revealing an unusual entanglement between bats & viruses. Provides new insights into bat biology & virus-host relationships. #batstemcells #viralbiology @CellCellPress @IcahnMountSinai
Bats have fascinated humans for centuries, but how they tolerate viruses remains a mystery. We investigate evolutionary adaptations of bats to deal with viral infections. #batimmunesystem #viralpathogens Photo: Daniel Whitby 2/ 
1/ Out now on @ScienceAdvances!
#StemCells are a wonderful tool to create atrial cardiomyocytes that spontaneously and continuosly beat in a dish… but what happens if we transfect them with the highly potassium selective channelrhodopsin WiChR? #Thread
science.org/doi/full/10.11…
#StemCells are a wonderful tool to create atrial cardiomyocytes that spontaneously and continuosly beat in a dish… but what happens if we transfect them with the highly potassium selective channelrhodopsin WiChR? #Thread
science.org/doi/full/10.11…
2/ WiChR is a channel that comes from the marine species Wobblia Lunata.
Differently from previosly described K+-conducting channels such as HcKcR1, this channel is characterized by small photocurrent inactivation and improved light sensitivity. #Thread #Physiology #Optogenetics
Differently from previosly described K+-conducting channels such as HcKcR1, this channel is characterized by small photocurrent inactivation and improved light sensitivity. #Thread #Physiology #Optogenetics
An Israeli biotech company, Renewal Bio that recently created mouse embryos using stem cells, has announced plans to make human embryos to harvest tissue for organ transplants and anti-aging procedures.
#Stemcells #biotech #biology #Syntheticbiology #Aging #transplant
#Stemcells #biotech #biology #Syntheticbiology #Aging #transplant
The scientist behind the work clarified that:
The synthetic embryos were not "real" embryos and did not have the potential to develop into live animals. But that is partly because they don't have the technology, right now, to do so.
The synthetic embryos were not "real" embryos and did not have the potential to develop into live animals. But that is partly because they don't have the technology, right now, to do so.
He admits to taking his "ground-breaking" technology to the next level and creating human embryos. The purpose is to harvest tissue to be used in transplant treatments meant to lengthen a person's life and health.
🔬An international consortium, led by #IRBBarcelona & the biotech company @MerusNV, reports the discovery of MCLA-158, the first clinical candidate screened in #organoids targeting 🎯 #cancer #stemcells of solid tumors.
📰@NatureCancer
➡️bit.ly/3MLiu3h
#IRBScience
📰@NatureCancer
➡️bit.ly/3MLiu3h
#IRBScience
Named Petosemtamab, the antibody MCLA-158 prevents the onset of #metastasis (that is, the spread of #cancer to other vital organs) and slows the growth of primary tumours in experimental models of cancer.
The study also lays the groundwork for the use of #organoids in the #DrugDiscovery process undertaken by pharmaceutical companies.
Organoids are patient-derived samples that can be grown in the laboratory, and they reproduce certain aspects of the tumour compartment.
Organoids are patient-derived samples that can be grown in the laboratory, and they reproduce certain aspects of the tumour compartment.
Do Bone Marrow Haematopoietic Stem and Progenitor Cells (#stemcells) influence #fattyliver, Core Liver Networks, and liver cancer?
Very happy to share our findings in this (5 min read) Tweetorial🧵
More details on bioRxiv:
#livertwitter
Very happy to share our findings in this (5 min read) Tweetorial🧵
More details on bioRxiv:
#livertwitter
2. In our previous publication in @CellSystemsCP, we used network analysis (#WGCNA) to identify the preserved liver networks (Core-Modules) between species and screened for their genetic regulators (module-eQTLs).
Infographic by Misaki Ouchida:
misakiouchida.com
Infographic by Misaki Ouchida:
misakiouchida.com
3. Here you can find a concise review/commentary on our previous paper on core liver networks in @CellRepMed
sciencedirect.com/science/articl…
sciencedirect.com/science/articl…
Study from @salkinstitute found that partial reprogramming using the #Yamanaka transcription factors (#Oct4, #Sox2, #Klf4 & #cMyc) for short periods of time:
-restored a youthful #epigenetic signature to #aging cells & extends the life span of a #premature #aging mouse model.
-restored a youthful #epigenetic signature to #aging cells & extends the life span of a #premature #aging mouse model.
-long-term partial reprogramming led to rejuvenating effects in different tissues, such as the #kidney & #skin, and at the #organismal level; duration of the treatment determined the extent of the beneficial effects.
-The rejuvenating effects were associated with a reversion of the #epigenetic clock and metabolic and #transcriptomic changes, including reduced expression of genes involved in the #inflammation, #senescence & #stressresponse pathways.
nature.com/articles/s4358…
nature.com/articles/s4358…
@IBDimmunology @DCharabaty @P_DeepakIBDMD @drvishal82 @MondayNightIBD @southasianIBD @nehagastrord @ibdesis @ownyourcrohns @FITWITMD @crohnsbabble @rebelliousgut @drsumitbhatia @DrAnjaliPandit @deepakjgastro @shivaramsingh @drroshanag @stevenbollipo @drkeithsiau @doctorboletoh @Rajatgastro @KailashKolhe @DrAnuraagJ @realTBpeople @anupam_gastro @UjjwalSonika @DrAshokGastro @vandana_midha @ashok_doctor @drakashmathur @Khanna_S @miNitinjagtap @jalpa_devi @DharJahnvi @SamirGadepalli @DrSamirAShah1 @SunandaKaneMD @UmaMahadevanIBD @BilalMohammadMD @AsadurRahman87 @ShimaghavimiMD @ibdmd_kaur @IBDMD @GKochharMD @KofiClarkeMD @JHashashMD @shanilkadir Safe ✈️ @IBDimmunology
08: 00 hrs 🇬🇧 🕰
A9/1
⭕️ Refractory Perianal #Fistula in #CD
A clear unmet need in #IBD as we set out in the #ECCO workshop pubmed.ncbi.nlm.nih.gov/26826183/
#MondayNightIBD
08: 00 hrs 🇬🇧 🕰
A9/1
⭕️ Refractory Perianal #Fistula in #CD
A clear unmet need in #IBD as we set out in the #ECCO workshop pubmed.ncbi.nlm.nih.gov/26826183/
#MondayNightIBD
@IBDimmunology @DCharabaty @P_DeepakIBDMD @drvishal82 @MondayNightIBD @southasianIBD @nehagastrord @ibdesis @ownyourcrohns @FITWITMD @crohnsbabble @rebelliousgut @drsumitbhatia @DrAnjaliPandit @deepakjgastro @shivaramsingh @drroshanag @stevenbollipo @drkeithsiau @doctorboletoh @Rajatgastro @KailashKolhe @DrAnuraagJ @realTBpeople @anupam_gastro @UjjwalSonika @DrAshokGastro @vandana_midha @ashok_doctor @drakashmathur @Khanna_S @miNitinjagtap @jalpa_devi @DharJahnvi @SamirGadepalli @DrSamirAShah1 @SunandaKaneMD @UmaMahadevanIBD @BilalMohammadMD @AsadurRahman87 @ShimaghavimiMD @ibdmd_kaur @IBDMD @GKochharMD @KofiClarkeMD @JHashashMD @shanilkadir A 9/2
Also highlighted by @LindAlliance as one of the top 10 priorities
led in 🇬🇧 by the brilliant @DrAilsaHart
pubmed.ncbi.nlm.nih.gov/27506537/
#MondayNightIBD
Also highlighted by @LindAlliance as one of the top 10 priorities
led in 🇬🇧 by the brilliant @DrAilsaHart
pubmed.ncbi.nlm.nih.gov/27506537/
#MondayNightIBD
@IBDimmunology @DCharabaty @P_DeepakIBDMD @drvishal82 @MondayNightIBD @southasianIBD @nehagastrord @ibdesis @ownyourcrohns @FITWITMD @crohnsbabble @rebelliousgut @drsumitbhatia @DrAnjaliPandit @deepakjgastro @shivaramsingh @drroshanag @stevenbollipo @drkeithsiau @doctorboletoh @Rajatgastro @KailashKolhe @DrAnuraagJ @realTBpeople @anupam_gastro @UjjwalSonika @DrAshokGastro @vandana_midha @ashok_doctor @drakashmathur @Khanna_S @miNitinjagtap @jalpa_devi @DharJahnvi @SamirGadepalli @DrSamirAShah1 @SunandaKaneMD @UmaMahadevanIBD @BilalMohammadMD @AsadurRahman87 @ShimaghavimiMD @ibdmd_kaur @IBDMD @GKochharMD @KofiClarkeMD @JHashashMD @shanilkadir @LindAlliance A 9/3
In 2022 are we addressing this unmet need in #CD #fistula
and help patients as in our vignette 🤔
@Jonathansegal85 @charlie_lees
pubmed.ncbi.nlm.nih.gov/34917313/
#MondayNightIBD
In 2022 are we addressing this unmet need in #CD #fistula
and help patients as in our vignette 🤔
@Jonathansegal85 @charlie_lees
pubmed.ncbi.nlm.nih.gov/34917313/
#MondayNightIBD
I will start my lab in July 2021 #HumanTechnopole
Looking forward to working with a dream team #Neurogenomics #HumanTechnopole
@gtesta72 @KalebicNereo @oliverharschnitz jose davila-valderrain
#neurodevelopmentaldisorders #stemcells #disordersofglycosylation
Looking forward to working with a dream team #Neurogenomics #HumanTechnopole
@gtesta72 @KalebicNereo @oliverharschnitz jose davila-valderrain
#neurodevelopmentaldisorders #stemcells #disordersofglycosylation
Thanks to all my mentors: they deeply shaped my thinking. Molecular neuroscience @RosaLab @CNRMIlano Cell biology meets developmental neuroscience @HuttnerLab @mpicbg Evolutionary neurobiology @SvantePaabo @MPI_EVA_Leipzig
A special thanks to Suhasa Kodandaramaiah @bksuhasa @uniminnesota. Developing a robot to study neural stem cells brought me out of my comfort zone. It was so much fun. I really look forward to our future projects.
#stemcellsmeetrobotics
#stemcellsmeetrobotics
main.icmr.nic.in/sites/default/…
Important @ICMR statement on evidence based use of #StemCell Therapy based on critical review of literature & claims by large panel of academic clinicians, which I had the privilege to lead. #StemCells often hyped & shouldn't be offered as #StandardOfCare
Important @ICMR statement on evidence based use of #StemCell Therapy based on critical review of literature & claims by large panel of academic clinicians, which I had the privilege to lead. #StemCells often hyped & shouldn't be offered as #StandardOfCare
Inherent public appeal of #StemCellTherapy is being exploited & promoted unethically as a #MagicRemedy to vulnerable patients & should be regulated. There are many diseases where Basic/Translational/Clinical Research can establish its utility @ISSCR @ICMR @fda @ema leads the way!
Acutely aware that patients & their groups want freedom to try whatever might help them & detest when the academic medical community or regulators are so hung up on #RiskBenefitRatio & good evidence and till then say this therapy they cannot take outside regulated clinical trials
1/Short thread on #Longevity
Longevity is a complex challenge, it appears that humans have a rough cap to #lifespan at about 120 years of age (even if you eat healthy, exercise and get lucky with great genes and a great environment).
Longevity is a complex challenge, it appears that humans have a rough cap to #lifespan at about 120 years of age (even if you eat healthy, exercise and get lucky with great genes and a great environment).
3/ There's promising data around #calorierestriction and #MTOR activating molecules like #rapamycin, which in other species can extend #lifespan by 10-15% (which if we're lucky, for the few it might extend the human lifespan cap to 132-138 years of age). discovermagazine.com/mind/the-two-f…
New paper! We developed an approach to perform scRNA-seq on islets from #stemcells after txp. We found the islets cured #diabetes & matured to very closely resemble real donor islets! Congrats to @WashUBME PhD co-1st authors @punnaug & @KristinaGMaxwel 1/n cell.com/cell-reports/f…
STORY TIME: This project concept has been a fantasy of mine since I was a graduate student, but the technology to do it robustly was simply not there until recently. Even then, we first performed the transplantations for this study in 2018, because of the extended timescales. 2/n
Many labs, including our own, had observed that pancreatic stem cell derivatives (pancreatic progenitors, endocrine progenitors, stem cell-derived islets (SC-islets) at varies stages of maturation) better controlled glycemia with extended time in mice. 3/n
Absolutely delighted to share the lab’s newest study showing that autism-iPSCs diverge from control-iPSCs from early development in a region-specific manner. Heroic work by @neuro_blue & wonderful collaboration with @sbaroncohen biologicalpsychiatryjournal.com/article/S0006-… What did we find? (thread)
Prenatal development may be a key period when differences associated with autism could be established. We studied early neurodevelopment using human iPSCs generated from autistic or typically developing individuals.
We found that autism-iPSCs displayed impaired ability to self-organise into neural rosettes, which are neurogeneic niches that give rise to neural progenitors that subsequently differentiate into neurons.
Meet Kevin Hendrawan, the PhD Student from the @SVH_BSCCR lab at St Vincent's Centre for Applied Medical Research @UNSW, the researcher helping us understand how people with #multiplesclerosis may benefit from stem cell transplantation
A thread 👇
#stemcells #transplant #Tregs
A thread 👇
#stemcells #transplant #Tregs
While our immune system is important for eliminating harmful foreign molecules and/or pathogens (like the virus causing COVID-19), it is equally important that it does not attack our own cells and organs (which is what occurs in autoimmune diseases).
This delicate balance is, in part, maintained by immune-suppressive cells known as T regulatory cells (Tregs).
(📸: blog.quartzy.com/iq_biosciences…)
(📸: blog.quartzy.com/iq_biosciences…)
#BSDBGenSoc2020 These days we all have other things in our minds, it is difficult to concentrate and many of my thoughts R w/ family anf friends in #Spain) but discussing our work, is an important part of our being and it is going to be important in the weeks and months to come.
While many, all, of us rather do al this in person, we are going to have to adjust in the weeks to come. #BSDBGenSoc2020 is a good way to explore how we are going to do it so, THANKS @_BSDB_ and @the_Node for organizing and running this.
My Tweetorial follows the phenomenal one from @TimFulton_1 @SteventonLab (with whom @AMA_Lab work closely) this morning and is very related.
And now onto the tweetorial in the form of a loooong thread.
And now onto the tweetorial in the form of a loooong thread.
(1/n) Delighted to share our work using #scRNAseq to explore the intersection between regeneration, development and #immune recognition in #cancer #metastasis online @NatureMedicine @sloan_kettering @WeillCornell @scell_papers @dana_peer @LabMassague
nature.com/articles/s4159…
nature.com/articles/s4159…
@NatureMedicine @sloan_kettering @WeillCornell @scell_papers @dana_peer @LabMassague (2/n) human primary #lungcancer is characterized by the emergence of regenerative cell types, typically seen in response to lung injury, but showing striking lineage promiscuity (identity confused!)
@NatureMedicine @sloan_kettering @WeillCornell @scell_papers @dana_peer @LabMassague (3/n) #metastasis exhibits a continuum of more primitive stem to epithelial progenitor states – driven in large part by key embryonic and lung-specifying transcription factors, SOX2 and SOX9.
