Discover and read the best of Twitter Threads about #Optogenetics

Most recents (3)

1/ Out now on @ScienceAdvances!

#StemCells are a wonderful tool to create atrial cardiomyocytes that spontaneously and continuosly beat in a dish… but what happens if we transfect them with the highly potassium selective channelrhodopsin WiChR? #Thread

science.org/doi/full/10.11…
2/ WiChR is a channel that comes from the marine species Wobblia Lunata.

Differently from previosly described K+-conducting channels such as HcKcR1, this channel is characterized by small photocurrent inactivation and improved light sensitivity. #Thread #Physiology #Optogenetics
3/ During my secondment and thanks to the collaboration with @JoH_VieR and other labs, we successfully transfected my hiPSC-derived atrial cardiomyocytes with WiChR.
This beating cluster in the video is one of those that I indented to get sharp electrode recording! #StemCell
Read 7 tweets
🧵 "Designing #ActiveMatter in Space-time"

Today's SFI Seminar by @SurajShankar92 (@Harvard), streaming now:
"I consider the Organism, or natural Machine, a machine in which each part is a machine."
- #Leibniz

🦠 Energy → Work

"Active matter *employs* control, either internally [e.g., embryogenesis] or externally [e.g., with sheepdogs]."
- @SurajShankar92
@SurajShankar92 A potent control mechanism for active matter: using #optogenetics to paint portraits and drive micro-robotic ensembles made of modified #bacteria.

"What are the rules you need to follow and the policies you need to enact?"
- @SurajShankar92 contemplates design principles:
Read 11 tweets
Brain mapping requires thorough synaptic measurements with diverse subclasses of neurons. Check out our latest #neuroscience publication: “Synaptic connectivity to L2/3 of primary visual cortex measured by two-photon #optogenetic stimulation”
📄 elifesciences.org/articles/71103 🧵 1
Our team [including @trav_ha, @timjarsky, @HongkuiZeng & @lukecampagnola] + @bakermind combined optogenetic stimulation with simultaneous multicellular recording to measure synaptic connections within cortical microcircuits. #optogenetics🧵 2
The reliability of multiphoton optogenetic stimulation was measured across Cre lines & connectivity measurements were verified by #patchclamp recordings 🧵 3
Read 8 tweets

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