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Multiplication in a single neuron. In a new @Nature article, @MalisJonatan, @BirteZuidinga, Axel Borst, and I describe the arithmetic of #Drosophila motion vision in biophysical terms. #Neuroscience @MPIforBI @MSCActions @EMBO (1/4) nature.com/articles/s4158… 
Using #PatchClamp #Ephys #InVivo, we recorded the membrane potentials of ON motion-sensing T4 neurons and their presynaptic partners. One type of input neuron (blue) provides continuous shunting inhibition. (2/4)
Only during visual motion in a T4 neuron’s preferred direction, well-timed release from inhibition amplifies coincident excitation in a multiplication-like fashion. Such ‘multiplicative disinhibition’ can approximate a logic AND gate. (#FlyPushing by @BirteZuidinga; 3/4)
Brain mapping requires thorough synaptic measurements with diverse subclasses of neurons. Check out our latest #neuroscience publication: “Synaptic connectivity to L2/3 of primary visual cortex measured by two-photon #optogenetic stimulation”
📄 elifesciences.org/articles/71103 🧵 1
📄 elifesciences.org/articles/71103 🧵 1
Our team [including @trav_ha, @timjarsky, @HongkuiZeng & @lukecampagnola] + @bakermind combined optogenetic stimulation with simultaneous multicellular recording to measure synaptic connections within cortical microcircuits. #optogenetics🧵 2
The reliability of multiphoton optogenetic stimulation was measured across Cre lines & connectivity measurements were verified by #patchclamp recordings 🧵 3
