Discover and read the best of Twitter Threads about #Longevity

David Vilchez

@TheVilchezLab

New work from the lab @NatureAging!❄️Lowering body temperature extends #longevity. We find that cold-induced #proteostasis prevents #aging and aggregation of proteins that cause age-related diseases #ALS #HuntingtonDisease in C. elegans and human cells nature.com/articles/s4358…

This was a tour de force by Hyun Ju Lee, @sedakoyuncu12, Hafiza Alirzayeva, @AlirezaBarandaq, and Amir Khodakarami (3 lab generations!). 1000x thanks to @impetusgrants for believing in us. Thanks to @CECAD_ @CGA_age @UniCologne @UKKoeln for their support

Aging is a major risk factor for neurodegenerative disorders linked with protein aggregation (#Alzheimers, #Parkinsonsdisease , #HuntingtonDisease, #ALS). We hypothesized that defining cold-induced changes can lead to converging modifiers of pathological protein aggregation🤔

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Dr Sudhir Kumar MD DM🇮🇳

@hyderabaddoctor

Lower resting heart rate (HR) and its health-related benefits

1. My resting HR has reduced from 72 bpm (in 2020) to 42 bpm (in 2023); mainly due to consistent running (average mileage of 15 km/day in 2021; 12.6 km/day in 2022) and weight loss (28 Kg)
#running #fitness #longevity

2. People with higher resting HR have a higher risk of death due to cardiovascular disease and cancers (breast, lung, kidney or colorectal cancers)
dx.doi.org/10.1136/heartj…

3a. In another study, people with RHR >75 bpm had 2-fold higher risk of all-cause death, or deaths due to stroke or heart attack (over 10-yr follow up), as compared to those with RHR <55 bpm.
Risk of all cause death increased by 3% for every bpm rise in RHR in the study period.

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Pandit AlokJagawat 🌞

@AlokJagawat

Prana rekhā #lifeline #jyotisa rules #mercury #Juiter #snake curse in hand #longevity devī’s grace
The prana rekhā starts from mercury and goes till the mount of Jupiter.
🦜Jupiter is prana & rules akas. It is wrongly called heartline in western palmistry
🦜 It starts from

mercury. Mercury is bookish knowledge, maths, vocabulary, memory etc. The purpose of life is to evolve above this base education and move to spiritual knowledge. Hence the lines start below Mercury.
🦜Chains, islands on this line will end the life early if visible in both hands.

Usually, Jupiter is afflicted in certain way in the chart and Saturn is strong in negative way.
🦜serpentine movement of this line indicates Rāhu afflicting Jupiter and person suffers from naga dośa
🦜If the line is cut from another line specially from mars the person loses

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Mickel Adzema

@sillymickel

This is a threaded version of Chapter 12:

“The Eleventh Descent—Sedentary Life...

"Sickness & Suffering:”

of *Prodigal Human: The Descents of Man*

by Michael Adzema.

READ CHAPTER THREAD or CLICK a link for free BOOK...

READ BOOK> sillymickel.blogspot.com/2022/02/prodig… #psychology

PH 12/1

Chapter 12 is subtitled,

“Eden Scorned—

“With Sedentary Living & Its Restricted Options for Sustenance, We Forego Perfect Assistance for Health of Body & Mind,

"Which Has Horrible Consequences”

THREAD wp.me/pwMlb-3in #psychology #devo #health #civilization

PH 12/2

[*Quotes/highlights:*] “Human Instinct, Comfort Feeding, & the Suffering Ape:

"Why would we “eat the apple”...

"that is, go it on our own with agriculture?

"Why would we defy Divine Providence in making our lots more painful or difficult?”

drive.google.com/file/d/1-dlEBH…

PH 12/3

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Arun Thareja,

@tharejaarun

#Astrology : #Longevity -Role of houses
Ascendant or Lagna signifies our Physical body which is ruled by Aries sign and natural Significator or Karak is Mars as Scorpio is 8th from Aries sign . Now Mars rules both Aries and Scorpio sign , So Mars becomes the prime significator

of our Longevity through 8th house significations.....
Now as 8th from any house becomes it's karak , in the same way 3rd from any house becomes it's mool karak.... So Mercury which rules our Natural 3rd house is the Significator of our Sub-conscious mind....
So for the

Activation of Life & energy in any Physical body or Sentient beings there are three fundamental elements and factors involved in its proper Functioning , first is Gross body which is the actual hardware represented by our first house and signified by Mars planet , second is

Read 11 tweets

Dr Sudhir Kumar MD DM🇮🇳

@hyderabaddoctor

The less we eat, the longer we live

1. This seems to be true.
A recent extensive review of studies done in geographies with maximum 100+ aged people showed that most of them practiced some form of calories restriction (CR) right from childhood.
#fasting #Longevity #MedTwitter

2. Calorie restriction (CR) is defined as consuming fewer (10-30% lower) calories as compared to usual.
This can be achieved by either intermittent fasting, or time-restricted feeding or substantially reducing carbohydrate intake.
#nutrition #HealthyEating

3. In ageing, #Insulin increases and insulin sensitivity decreases, which increase the risk of #diabetes, #obesity and #cardiovascular diseases. CR reverses these- reduces insulin levels and increases insulin sensitivity. #Glucose levels also reduce with CR.

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Nick Krontiris

@nick_krontiris

This one found that Sicilian long-lived individuals have changes in circulatory fatty acids status with advancing age, characterized by a reduction in blood levels of total PUFA and trans FA with age, whereas total SFA remained unchanged throughout life.

- This fatty acid profle characterized by high MUFA content may indicate reduced peroxidation while maintaining membrane fluidity.

- "We suppose that the high consumption of the extra virgin olive oil (EVOO) may have infuenced this datum"

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Nick Krontiris

@nick_krontiris

This one suggests that age acceleration is associated with lower strength and/or loss of strength over time in US adults aged 51 years and older, followed over an 8-10 year period.

- "A growth in research evidence documents that epigenetic phenomena, such as DNA methylation (DNAm), are highly implicated in the development of disease and rate of biological ageing...

Ref:
doi.org/10.1186/s13059…

"...Given that methylation profiles are thought to be modifiable by lifestyle and other environmental factors, it has been proposed that DNAm age is a robust biological ageing clock providing a superior estimate of true biological age over chronological age...

Read 13 tweets

Nick Krontiris

@nick_krontiris

Using Mendelian randomization analysis and conventional analysis, this one finds fat mass to be causally and linearly associated with all-cause mortality, while showing that the obesity paradox found in observational analyses can be explained by high-risk lifestyle choices.

- The phenomenon where a higher BMI correlates with lower mortality risk has been called the obesity paradox.

- In order to investigate the association between fat mass and mortality and mortality not only among the whole population, but to be able to stratify in subgroups as well, the authors used six well-known lifestyle risk factors to assess high/low risk lifestyles.

Read 12 tweets

Dr Sudhir Kumar MD DM🇮🇳

@hyderabaddoctor

Association of Muscle-Strengthening and Aerobic Physical Activity With Mortality in US Adults Aged 65 Years or Older
jamanetwork.com/journals/jaman…
#exercise #Longevity #mortality #elderly

1. As little as 10 min/wk of aerobic exercises caused lesser deaths in elderly as compared to <10 min.
2. Benefits of aerobic activity were seen up to 300 min or more per week.
3. 32% lower deaths occurred with >300 min/wk of aerobic exercises as compared to 17% in 10-150 min grp

4. For muscle strengthening activity (MSA), the effect on death rate was U shaped. Deaths were higher with <2 and >6 sessions of MSA. Lowest deaths occurred in elderly doing 2-6 sessions of MSA.

Read 4 tweets

Nick Krontiris

@nick_krontiris

Using data from 3095 people living in Sweden, this one identified the most relevant predictors of 18-year mortality in individuals aged ≥60 years.

- Individuals’ social connections and civil status were identified as meaningful predictors of mortality, as well as socio-environmental characteristics such as living conditions, civil status, and leisure activities.

- Physical function also had a strong prognostic role, as the functional status domain, encompassing several measures of physical performance and dependency, was the only single domain that showed comparable predictive performance to chronological age.

Read 12 tweets

Nick Krontiris

@nick_krontiris

This systematic review comes to the conclusion that physical activity with regular aerobic training of moderate to vigorous intensity appears to help preserve leukocyte telomere length, a biomarker of biological aging associated with several age-related diseases.

* Key points:

- As life-expectancy increases, lifestyle choices like exercise take on increasing importance in healthy aging.

Read 15 tweets

Dr. Atilla Ozmumcu🐞

@AtillaOzmumcu

🛑30 yılı geçen bir zamandır uzun yaşam, #lifespan #LONGEVITY sağlıklı yaşam ile uğraşıyorum. Biohacker bile sayılabilirim. Kendi üzerimde DMSA(dimercapto succinic acid)+Alpha Lipoic Acid saatlik zaman kombinasyonu yapmışlığım var. Bu siklusu rahmetli Prof. Dr. Ahmet Aydın
(1)

ile beraber Cerrahpaşa Adli Tıp Anabilim dalında yapmıştık.
Zaman zaman buradan sağlıklı yemekler paylaşıyorum.
Beni yakından takip edenlerin bildiği gibi pesketaryanım yani kırmızı et, beyaz et, hayvansal bir gıda almıyorum. Sadece balık ve yumurta yiyorum.
Buğday-buğday
(2)

ürünleri, süt ve süt ürünleri, paketlenmiş, kutulanmış hiç bir şey soframızda yer almaz.
Bugün sizlere çok kısık ateşte 47-50 dereceyi geçmeden pişirdiğim Somon balığından bahsedeceğim.
(Avlanma mevsimi hariç yabanıl balık da yemiyorum.)
Asla yapışmaz tabanlı her hangi bir
(3)

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nextbigfuture

@nextbigfuture

1/15 I interview antiaging expert Aubrey de Grey. He has been interviewed by Joe Rogan and 60 minutes. He corrects mistaken views on aging and talks big new developments. significant human life extension by 2035 #aging #antiaging #Future youtube.com/embed/xWAIb1Mv…

2/15 Next Level Funding has been reached for Antiaging has been reached. Over $12B+ invested. Billions from Jeff Bezos and Saudi Hevolution fund. Progress is not money limited.

youtube.com/embed/xWAIb1Mv…

3/15 Antiaging expert Aubrey de Grey talks new trends and big new antiaging developments

youtube.com/embed/xWAIb1Mv…

Read 15 tweets

a2 Collective | a2PilotAwards.ai

@a2_collective

Interested in 2nd a2PilotAwards.ai for projects at the intersection of #AI and #healthyaging?

Register for our July 14 webinar and Q&A with @JH_AITC, @pennaitech, and #MassAITC:

a2PilotAwards.ai/webinar

#agetech #ADRD #aging #longevity #healthtech #digitalhealth

@JeremyWalstonMD @Rock1MD @TonyTeano @EstherOh_MDPhD @AliciaArbaje @bbuta410 @JHUCarey @HopkinsMedicine @HopkinsEngineer @jhu_coah @JHUMCEH @JHUAPL @jhuclsp @hopkins_HAP Register: a2PilotAwards.ai/webinar

@niteeshchoudhry @UMassAmherst @BrighamWomens Register: a2PilotAwards.ai/webinar

Read 6 tweets

Martin Borch Jensen

@MartinBJensen

If you want to build a career in biotech, should you get a PhD after college or join a company directly (as a Research Associate/RA, usually)?
There's no single answer, but I have the conversation often enough that I thought I'd share some pros/cons... (1/n)

First, see this thread about different types of biopharma companies. For reasons I'll get into, I think early stage (probably founder led) biotech is your best bet unless you still want to do PhD later.
(PS if you want to be a professor, it's 💯 PhD) 2/n

https://twitter.com/MartinBJensen/status/1543679616639938560?s=20&t=l9hxBM8wVkjetgL2813t7w

PhD will give you more options.
Some companies (incl. @GordianBio) will help you grow from RA to Scientist role (and beyond). But many, esp larger, companies have a glass ceiling if you don't have a PhD. Even if you pick one w/o glass ceiling, you'll be worse off it if fails. 3/n

Read 13 tweets

Elie🔺🇺🇦

@ElieRest

6 months anniversary of @colonylab! 🥳

Born at the top of the bull market, now thriving in the bear market. It has been quite a journey already!🔺

A thread to review what has been achieved and what’s next! A big thank you to our amazing community 🤗

🧵Thread to celebrate!
1/21

To start with, the team is glad to build on #Avalanche. It’s a robust platform, with amazing uptime & performances! 💯

From a development perspective we couldn’t ask for more (almost 😉)!

Many other platforms can’t say the same so I want to highlight this one! 🚀

2/21

The nascent #Avalanche community is amazing & everyone is starting to realize it.

We’re going through hardship together and you all know the destination! 💫

It’s a pleasure to ship innovative features with @colonylab for our beloved community! 🙌🏼

3/21

Read 21 tweets

Dr. Atilla Ozmumcu🐞

@AtillaOzmumcu

🛑Resveratrol konusuna tekrar döneyim.
Resveratrol için #lifespan #longevity uzun yaşam ve sağlıklı hayat dünyasında kirli ilaç, dengesiz ilaç (dirty drug) deyimi kullanılır.
İki formu bulunur.
Trans ve Cis formları.
Bu iki formun arasındaki kimyasal fark ile başınızı şişirmek(1)

istemem.
Bu yüzden kısaca Trans formunu, yani üzerinde Trans Resveratrol yazanı kullanmanız gerek diyerek işinize yarayan bilgiyi yazayım.
Besin desteği olarak sunulan Trans Resveratrollerin neredeyse hepsi Japon Madımağı (Japanese Knotweed) bitkisinden elde edilir.
Yani (2)

resveratrol sadece kırmızı üzüm kabuğu veya çekirdeğinde bulunmaz. Ticari olarak daha dengeli ve karlı üretimi japon madımadığından elde edilenidir.
Resveratrol yağda çözünen bir maddedir. Dolayısıyla sadece su ile içmek emilimini azaltır. En iyisi resveratrolü bir miktar (3)

Read 13 tweets

Omar Mossad

@OmarMglia

Does #gut #microbiota interact with #microglia in the #aging #brain? Are microglia metabolically affected (#mitochondria)? Does #diet take part? any #translational data?
Our paper made it last week in @NatureNeuro
so it's about time for a 🧵!
nature.com/articles/s4159…

1. Microglia from aged and young-adult #male & #female mice, under SPF or #germ_free conditions were profiled by bulk #RNAseq. We identified a gene-set, which depended on the housing condition regardless of #age & regulate central processes in microglia. "Microglial GF signature"

2. Utilizing #WGCNA, we found major differences between microglia of SPF and GF mice in the aged groups. But do we see any functional difference on a cellular level?

Read 13 tweets

Gastro-One

@GastroOneIndia

#LONGEVITY @ravikanths_
IS 80 THE NEW 60?
I certainly hope so.

“Not only has life span increased on average, but also health span has increased,” said Olivia I. Okereke, M.D., associate professor of psychiatry at Harvard Medical School and associate professor of epidemiology at the Harvard T.H. Chan School of Public Health.

“As a result, more older people than ever seem to lead healthy lives, engaged in a full range of activities — including in business, science, politics, and cultural and civic life.”

news.harvard.edu/gazette/story/…

Read 3 tweets