Discover and read the best of Twitter Threads about #rapamycin
Most recents (8)
1/3
Most answers to questions on #rapamycin, including dosing, you may find in this paper, if you read it slowly to its end. Anti-aging doses have no side-effects by definition: highest doses that do not cause side effects and you are comfortable with.
ncbi.nlm.nih.gov/pmc/articles/P…
Most answers to questions on #rapamycin, including dosing, you may find in this paper, if you read it slowly to its end. Anti-aging doses have no side-effects by definition: highest doses that do not cause side effects and you are comfortable with.
ncbi.nlm.nih.gov/pmc/articles/P…
2/3
Doses and schedules are individual and must be personalized under doctor supervision. They may range widely. In my case, I never had side effects at relatively high doses (20 mg/2 weeks) compared to typical 6 mg/week. Will shift to 24, probably. But do not do that on your own
Doses and schedules are individual and must be personalized under doctor supervision. They may range widely. In my case, I never had side effects at relatively high doses (20 mg/2 weeks) compared to typical 6 mg/week. Will shift to 24, probably. But do not do that on your own
3/3
Rapamycin may be combined with (under supervision):
Daily physical exercise
Low carb diets
Metformin
Vit B3 derivates, D3
And others discussed in the paper on 1/3 tweet
Rapamycin may be combined with (under supervision):
Daily physical exercise
Low carb diets
Metformin
Vit B3 derivates, D3
And others discussed in the paper on 1/3 tweet
1/Short thread on #Longevity
Longevity is a complex challenge, it appears that humans have a rough cap to #lifespan at about 120 years of age (even if you eat healthy, exercise and get lucky with great genes and a great environment).
Longevity is a complex challenge, it appears that humans have a rough cap to #lifespan at about 120 years of age (even if you eat healthy, exercise and get lucky with great genes and a great environment).
3/ There's promising data around #calorierestriction and #MTOR activating molecules like #rapamycin, which in other species can extend #lifespan by 10-15% (which if we're lucky, for the few it might extend the human lifespan cap to 132-138 years of age). discovermagazine.com/mind/the-two-f…
358/ #Alzheimers
Question on my cognitive quiz yesterday
How many animals can you name in one minute?
Test your ability. Have someone time you.
Prep for your cognitive exam.😉
@LukeEdwards504 @Gearoidmuar @reelbryanwilson
@julie_eye
My answer below
meandgin.blogspot.com/2020/08/how-ma…
Question on my cognitive quiz yesterday
How many animals can you name in one minute?
Test your ability. Have someone time you.
Prep for your cognitive exam.😉
@LukeEdwards504 @Gearoidmuar @reelbryanwilson
@julie_eye
My answer below
meandgin.blogspot.com/2020/08/how-ma…
359/ #Alzheimers
I am 9 months into writing my 3rd book on my AZ
I am providing a link that will take you to the draft.
The Pursuit of Happiness w AZ
docs.google.com/document/d/1IU…
@LukeEdwards504 @Gearoidmuar @julie_eye @bmaccullough @reelbryanwilson @FatEmperor @ZKForTre @johnzahorik
I am 9 months into writing my 3rd book on my AZ
I am providing a link that will take you to the draft.
The Pursuit of Happiness w AZ
docs.google.com/document/d/1IU…
@LukeEdwards504 @Gearoidmuar @julie_eye @bmaccullough @reelbryanwilson @FatEmperor @ZKForTre @johnzahorik
360/ #Alzheimers
I updated my draft today for the complete 9 months of my third year with AZ.
The free draft can be read at:
docs.google.com/document/d/1IU……
I updated my draft today for the complete 9 months of my third year with AZ.
The free draft can be read at:
docs.google.com/document/d/1IU……
weight of #centenarians in Austria (> 100 years old)
For men, body weights 60 kg (132 lb), heights 167 cm; #BMI 21.5.
For women, body weights 52 kg (115 lb); heights 149 cm; BMI 22.8
academic.oup.com/biomedgerontol…
For men, body weights 60 kg (132 lb), heights 167 cm; #BMI 21.5.
For women, body weights 52 kg (115 lb); heights 149 cm; BMI 22.8
academic.oup.com/biomedgerontol…
Low weights are expected of course. But note low heights 167 cm, 149 cm (non-centenarian heights are 179 and 166 for men and women in Austria). One of explanations is that mTOR drives both growth and aging
ncbi.nlm.nih.gov/pmc/articles/P…
ncbi.nlm.nih.gov/pmc/articles/P…
Of course we cannot (and should not) decrease our heights (developmental growth) but we can decrease mTOR activity later in life by low calories diets, fasting, #keto, #rapamycin etc
True anti-aging intervention must delay age-related diseases, extending healthspan. As the simplest example, low Cal/low Carb diets/fasting/exercise do that. Aging kills via age-related diseases in humans and all animals, including worm and flies 1/3
ncbi.nlm.nih.gov/pmc/articles/P…
ncbi.nlm.nih.gov/pmc/articles/P…
Drosophila also dies from age-related diseases
It is well known that mTOR drives aging and #rapamycin extends lifespan in flies. Its shown now that mTOR kills Drosophila via age-related diseases 2/3
ncbi.nlm.nih.gov/pmc/articles/P…
It is well known that mTOR drives aging and #rapamycin extends lifespan in flies. Its shown now that mTOR kills Drosophila via age-related diseases 2/3
ncbi.nlm.nih.gov/pmc/articles/P…
And in rodents rapamycin and everolimus delay all age-related diseases including cancer
(hundreds and hundreds of papers) 3/3
(hundreds and hundreds of papers) 3/3
1 approach to understanding #covid19 infection is to examine co-morbidities & ask what's common?
Most prevalent Cov19 co-morbs:
1)↗️age
2)Hypertension
3)Diabetes
4)Cardiovascular disease
5)Kidney disease
6)Chronic respiratory disease (esp COPD)
8)Cancers
9)BMI>40
10)♂️>♀️
Most prevalent Cov19 co-morbs:
1)↗️age
2)Hypertension
3)Diabetes
4)Cardiovascular disease
5)Kidney disease
6)Chronic respiratory disease (esp COPD)
8)Cancers
9)BMI>40
10)♂️>♀️
2/
These are diverse diseases & increasing age technically not a disease at all. However, there is at least 1 factor in common among all of the co-morbidities identified thus far:
INFLAMMATION
These are diverse diseases & increasing age technically not a disease at all. However, there is at least 1 factor in common among all of the co-morbidities identified thus far:
INFLAMMATION
3/
A survey of the co-morbidities revealed another commonality; a close association w/ dysregulation of the pro-inflammatory, neutrophil-recruiting cytokine, IL-17A.
IL-17A is made by multiple immune cell types, including lung-resident innate lymphoid cells (ILC3s).
A survey of the co-morbidities revealed another commonality; a close association w/ dysregulation of the pro-inflammatory, neutrophil-recruiting cytokine, IL-17A.
IL-17A is made by multiple immune cell types, including lung-resident innate lymphoid cells (ILC3s).
I predict that so-called more selective mTORC1 inhibitors will have equal or inferior antiaging effects compared with #rapamycin. I predict that maximal anti-aging effect will be achieved with a combination of high doses of rapamycin plus low doses of pan-mTOR inhibitors
such as Torin-1, which can inhibit rapamycin-insensitive functions of #mTORC1. But doses must be low to avoid inhibition of other kinases and side effects. Thus High rapamycin plus Low pan-mTOR inhibitor
All my previous predictions were confirmed
ncbi.nlm.nih.gov/pubmed/20436272
ncbi.nlm.nih.gov/pubmed/20436272
"Better" rapalogs are patented #rapalogs so can attract investments and grants. Better rapalogs never showed life extension in any animal yet. They will be better, when, and only when, they extend life longer than "not-better" rapalogs. Better rapalogs were not given to humans.
Even if better, they will not be available soon. Current (“not better”) rapalogs (#rapamycin, everolimus) showed no side effects in all three studies in the elderly. Furthermore, they can be used intermittently and discontinued when any slight doubt emerges.
I always emphasized that no one should take rapamycin or any other rapalogs as self-experimentation, no one. Potential treatment should be performed by a doctor and under doctors’ supervision
