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"Better" rapalogs are patented #rapalogs so can attract investments and grants. Better rapalogs never showed life extension in any animal yet. They will be better, when, and only when, they extend life longer than "not-better" rapalogs. Better rapalogs were not given to humans.
Even if better, they will not be available soon. Current (“not better”) rapalogs (#rapamycin, everolimus) showed no side effects in all three studies in the elderly. Furthermore, they can be used intermittently and discontinued when any slight doubt emerges.
I always emphasized that no one should take rapamycin or any other rapalogs as self-experimentation, no one. Potential treatment should be performed by a doctor and under doctors’ supervision
