Discover and read the best of Twitter Threads about #transcription
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Forget ChatGPT, these 8 AI tools will supercharge your productivity in no time 🔥
Let's dive into it! #ai
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looka.com is an AI-powered platform that helps you create a logo, brand identity, and marketing materials in minutes. No design skills are required. #looka
stockimg.ai/is a great tool for designing logos, posters, book covers, art, etc…
Proud of this collaboration, getting to the bottom of the links between chromatin mobility, #transcription control and #loopextrusion processes, now on bioRxiv:
biorxiv.org/content/10.110…
1/8
@mitchell_lab @tinekelenstra @EviSoutoglou @molina_lab @AkisPapantonis @kerstinbys
biorxiv.org/content/10.110…
1/8
@mitchell_lab @tinekelenstra @EviSoutoglou @molina_lab @AkisPapantonis @kerstinbys
We tagged the Sox2 promoter and enhancer for their simultaneous tracking in live ES cells. While the two elements were frequently close , this distance remained largely unchanged on different means of inhibiting gene transcription.
2/8
2/8
More importantly, we found that the promoter and enhancer were significantly less mobile than control regions. This was predicted by molecular dynamics simulations, taking loop extrusion and transcription factor-mediated clustering into account.
3/8
3/8
Are you interested in learning about #bioinformatics and working with #genomic data? Here's a detailed #learning path to get you started:
To build a strong foundation in biology, you'll need to learn about:
The #structure and #function of #cells, including the various #organelles and their roles in the cell. This will help you understand how cells work and how they carry out essential functions such as #metabolism and #energy production.
Guide sur la transcription écrite pour une meilleure accessibilité.
Retrouvez notre thread sous forme de visuels sur Instagram sinon vous avez notre thread sous forme de texte ci-dessous. 😉
instagram.com/p/CbPNX75qlPp/…
#Transcription #Accessibilité #Podcast #Podcaccessible
Retrouvez notre thread sous forme de visuels sur Instagram sinon vous avez notre thread sous forme de texte ci-dessous. 😉
instagram.com/p/CbPNX75qlPp/…
#Transcription #Accessibilité #Podcast #Podcaccessible
Le sous-titrage et la transcription écrite sont tout indiqués pour rendre accessible à un grand nombre de personnes ou encore améliorer la visibilité de votre contenu et créer de l’engagement.
Avec ce guide, nous voulons vous faire découvrir la transcription écrite ainsi que quelques bonnes pratiques pour produire une transcription de qualité.
Le sous-titrage fait l’objet d’un autre guide afin de ne pas s’emmêler les pinceaux.
Le sous-titrage fait l’objet d’un autre guide afin de ne pas s’emmêler les pinceaux.
Thrilled to share our latest work, now in @ScienceMagazine! Exploring how #3DGenome organization controls #transcription dynamics during #development. A few highlights below! #InHoxWeTrust
@XinyangBing
Zachary Sisco
@J_Raimundo_
@Michal_Levo
Mike Levine
science.org/doi/10.1126/sc…
@XinyangBing
Zachary Sisco
@J_Raimundo_
@Michal_Levo
Mike Levine
science.org/doi/10.1126/sc…
The Drosophila genome is organized by 2 types of elements: tethers mediate focal contacts, while insulators establish #TAD boundaries. We used genome editing and live transcription imaging to explore their roles in the temporal regulation of #Hox gene expression in the embryo.
Transcription of the endogenous Scr gene, live! Active transcription foci (white spots) appear in a narrow stripe of nuclei (blue) just prior to the onset of gastrulation. (Scr-MS2, MCP-GFP, His2A-RFP)
1/ The DNA of the cell serves as a master blue print. Every cell of our body has a complete copy of this
DNA blueprint. Depending on the cell and its functions, it will use specific parts of the blueprint found in the DNA to produce the proteins and enzymes needed by that cell.
DNA blueprint. Depending on the cell and its functions, it will use specific parts of the blueprint found in the DNA to produce the proteins and enzymes needed by that cell.
2/ The rule is that each gene creates
one fully functional protein or enzyme.
one fully functional protein or enzyme.
Our first paper authors.elsevier.com/a/1cRqD6tu0Cbo… is now out @CellStemCell! With @ionispharma & the Jamieson Lab @UCSanDiegoDRM, we found that selective #antisense oligonucleotides inhibiting #IRF4 reduce disease burden & #multiplemyeloma #regeneration in #cancer models. @CellPressNews 1/
IRF4 (interferon regulatory factor 4) is a key plasma cell transcription factor that is known to play a critical role in #myeloma progression. It's been shown to activate networks of #cellcycle and cancer regulators, including the notorious #cancer and #stemcell gene, #MYC. 2/
In this new work, the talented @PhoebeMondala & @AshniVora first dug deeper into the IRF4 networks activated in high-risk forms of #myeloma, including #plasmacellleukemia. IRF4 target genes (SLAMF7, BCMA) were widely induced, especially among genes regulating the #cellcycle. 3/
Highlights from our #preprint on #transcription activation domains (ADs)!
-found all ADs in yeast TFs
-predicted yeast & human ADs
-tested binding of all ADs to #Mediator & #TFIID
-explained mechanism with structural modeling & kinetic experiments
(1/16)
biorxiv.org/content/10.110…
-found all ADs in yeast TFs
-predicted yeast & human ADs
-tested binding of all ADs to #Mediator & #TFIID
-explained mechanism with structural modeling & kinetic experiments
(1/16)
biorxiv.org/content/10.110…
We tested ~7500 53aa tiles covering all 164 yeast transcription factors (TFs) in an activation screen in vivo.
By controlling for fragment expression & sorting GFP activation into 8 bins, we get quantitative measurements with super high signal-to-noise. We found 150 ADs. (2/16)
By controlling for fragment expression & sorting GFP activation into 8 bins, we get quantitative measurements with super high signal-to-noise. We found 150 ADs. (2/16)
Tiles with lots of acidic & hydrophobic residues activated most.
But there are conflicting reports on whether acidic residues are important, so we mutated all the acidic residues in each AD. Besides one interesting case, no mutants activated.
So all yeast ADs are acidic! (3/16)
But there are conflicting reports on whether acidic residues are important, so we mutated all the acidic residues in each AD. Besides one interesting case, no mutants activated.
So all yeast ADs are acidic! (3/16)
Please enjoy our new #preprint, "High-throughput discovery and characterization of human transcriptional effectors"! 😀
We tested thousands of protein domains and mutants for the ability to repress/activate #GeneExpression and ID effectors in 600 proteins
biorxiv.org/content/10.110…
We tested thousands of protein domains and mutants for the ability to repress/activate #GeneExpression and ID effectors in 600 proteins
biorxiv.org/content/10.110…
For many human #TranscriptionFactors & #chromatin regulators, we know more about *where* they bind than *how* they regulate expression
To find effector domains in an unbiased way, we tested a library of the majority of nuclear protein domains with our new method, HT-recruit
To find effector domains in an unbiased way, we tested a library of the majority of nuclear protein domains with our new method, HT-recruit
We find hundreds of human #repressor domains, including several domains of unknown function
National DNA Day:
🧬April 25
🧬Commemorates the day in 1953 when Watson, Crick, Wilkins, Franklin and colleagues published papers in the journal @nature on the structure of DNA
🧬Also commemorates the completion of the Human Genome Project in April 2003, took 13 years
#DNADay
🧬April 25
🧬Commemorates the day in 1953 when Watson, Crick, Wilkins, Franklin and colleagues published papers in the journal @nature on the structure of DNA
🧬Also commemorates the completion of the Human Genome Project in April 2003, took 13 years
#DNADay
DNA Double Helix:
🧬The two #DNA strands are reverse-complements
🧬Reading one strand in #reverse order and exchanging each base with its #complement gives the other strand
🧬A and T are complements, C and G are complements
DNA Sequence: AGTAGCAT
Reverse-Complement: ATGCTACT
🧬The two #DNA strands are reverse-complements
🧬Reading one strand in #reverse order and exchanging each base with its #complement gives the other strand
🧬A and T are complements, C and G are complements
DNA Sequence: AGTAGCAT
Reverse-Complement: ATGCTACT
In #Each DNA Strand:
🧬Pull the #DNA double helix apart, leaving the two single DNA strands
🧬The population (or occurrence) of every DNA sequence in that single-strand is #equivalent to the population of its reverse-complement DNA sequence in that same single-strand
#Genomics
🧬Pull the #DNA double helix apart, leaving the two single DNA strands
🧬The population (or occurrence) of every DNA sequence in that single-strand is #equivalent to the population of its reverse-complement DNA sequence in that same single-strand
#Genomics
I was born and raised in the beautiful city of #Curitiba, southern #Brazil!
This region is famous for being cold and cloudy (yes it can be cold in Brazil!).
It is also famous for its very endemic and beautiful #Araucaria pine trees. #voicesIWS @IWS_Network @500womensci /1
This region is famous for being cold and cloudy (yes it can be cold in Brazil!).
It is also famous for its very endemic and beautiful #Araucaria pine trees. #voicesIWS @IWS_Network @500womensci /1
#Actions speak louder than words! I am thankful for my parents for being who they are. Both always showed love for Nature, different interests and #curiosity! So no wonder by observing them I grew up to be a very curious girl who really loved Nature. #voicesIWS @IWS_Network /2
During High School I became fascinated by the #mendelian #genetics classes and the work of #gregormendel! I also loved studying animals, ecosystems and climate so the obvious choice for me in University (@PUCPR_oficial ) was BIOLOGY!! @IWS_Network #womeninscience #voicesIWS /3
