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Please enjoy our new #preprint, "High-throughput discovery and characterization of human transcriptional effectors"! 😀
We tested thousands of protein domains and mutants for the ability to repress/activate #GeneExpression and ID effectors in 600 proteins
biorxiv.org/content/10.110…
We tested thousands of protein domains and mutants for the ability to repress/activate #GeneExpression and ID effectors in 600 proteins
biorxiv.org/content/10.110…
For many human #TranscriptionFactors & #chromatin regulators, we know more about *where* they bind than *how* they regulate expression
To find effector domains in an unbiased way, we tested a library of the majority of nuclear protein domains with our new method, HT-recruit
To find effector domains in an unbiased way, we tested a library of the majority of nuclear protein domains with our new method, HT-recruit
We find hundreds of human #repressor domains, including several domains of unknown function
