Discover and read the best of Twitter Threads about #statin
Most recents (12)
1a) Welcome to a live-tweeted, #accredited #tweetorial from @nationallipid #NLA23 in #Atlanta on advances in #hyperlipidemia management #LLT. Our expert returning faculty is Pam R. Taub, MD @PamTaubMD #cardiologist from @UCSDHealth 
1b) Dr. Taub is a clinician/scientist and is a frequent contributor to our #accredited programs. She is the founding director of the Step Family Foundation Cardiac Rehabilitation and Wellness Center at #UCSD.
#FOAMed #cardiotwitter @MedTweetorials #MedEd #lipids
#FOAMed #cardiotwitter @MedTweetorials #MedEd #lipids
2) This program is supported by an educational grant from Esperion Therapeutics & is intended for #HCPs. Statement of accreditation & faculty disclosures at cardiometabolic-ce.com/disclosures/. Earn 0.75 hr 🆓CE/#CME by following this 🧵!
🧵 Thread on my statin research 👇🏼
Our analysis in @JAMAInternalMed
21 statin trials, 143,532 participants
The benefits of #statins were minimal & most trial participants who took statins, derived no clinical benefit.
Reducing LDL-C with statins showed an inconsistent/weak… twitter.com/i/web/status/1…
Our analysis in @JAMAInternalMed
21 statin trials, 143,532 participants
The benefits of #statins were minimal & most trial participants who took statins, derived no clinical benefit.
Reducing LDL-C with statins showed an inconsistent/weak… twitter.com/i/web/status/1…
We respond to a critique by @PeterAttiaMD of our systematic review and meta analysis of #statin trials
tinyurl.com/rssdns32
tinyurl.com/rssdns32
Proposed guidelines in the UK recommend #statins to all adults if “the person is happy to take a statin”.
Here’s why it’s a bad idea 👇🏼
tinyurl.com/254987zj
Here’s why it’s a bad idea 👇🏼
tinyurl.com/254987zj
Are you a caring person?
Will you take action to save others from harm?
For example, if you see a child crossing the street on a green traffic light, would you pull them back to prevent them from being hit by a car?
@THiNKX2
1/
Will you take action to save others from harm?
For example, if you see a child crossing the street on a green traffic light, would you pull them back to prevent them from being hit by a car?
@THiNKX2
1/
What will you do when you see thousands of people dying above the average?
Excess deaths: app.powerbi.com/view?r=eyJrIjo…
@THiNKX2
2/
Excess deaths: app.powerbi.com/view?r=eyJrIjo…
@THiNKX2
2/
We have responded to a critique of our 2022 analysis on statins (published in @JAMAInternalMed)
The critique was written by physician, podcaster @PeterAttiaMD
Join in the #statin discussion on Substack 👇👇
maryannedemasi.substack.com/p/response-to-… @pbyrne82 @mjones110164 @DrPaulMason
🧵👇
The critique was written by physician, podcaster @PeterAttiaMD
Join in the #statin discussion on Substack 👇👇
maryannedemasi.substack.com/p/response-to-… @pbyrne82 @mjones110164 @DrPaulMason
🧵👇
Too often, statin advocates will communicate a drug’s relative risk reduction (impressive number), without quoting the absolute risk reduction (trivial number), a practise we consider unethical (see graph)
The FOURIER trial was cited as evidence of benefit but it did not show a mortality benefit. In fact, there were more cardiovascular deaths and total deaths in the group taking the PCSK9 inhibitors compared to placebo, albeit not statistically significant.
What can patients do to lower #cholesterol levels, if they can not take #statin due to any reason?
1. They can take #garlic and #lemon juice, if statins are contraindicated or causing any #adverse effects such as myalgia or muscle weakness.
#MedTwitter
doi.org/10.4103%2F2008…
1. They can take #garlic and #lemon juice, if statins are contraindicated or causing any #adverse effects such as myalgia or muscle weakness.
#MedTwitter
doi.org/10.4103%2F2008…
2. High cholesterol level is a risk factor for stroke and heart attacks. Statins are commonly prescribed drugs to lower cholesterol levels. However, some patients can not take statins due to adverse effects such as muscle pain and muscle weakness.
#Diet #nutrition #healthydiet
#Diet #nutrition #healthydiet
3. In a study, 20 gram of raw garlic and one tablespoon of lemon juice was given daily for 8 weeks in people with high chol. Total cholesterol reduced by 41 mg/dl, LDL cholesterol reduced by 30 mg/dl and BMI reduced by 1.6. (Ref: International Journal of Preventive Medicine 2016)
I have never claimed to be fashionable and rarely do I ever match ☺️
I am wearing my heart shoes and my red dress tie from @HeartNews @AHAScience @GoRedForWomen
#AHA22 Day 1
I am wearing my heart shoes and my red dress tie from @HeartNews @AHAScience @GoRedForWomen
#AHA22 Day 1
My shoe buddy and frankly the genesis for why I purchased these shoes @KnightSNPs
Stop by S3156. Dr Knights poster on #disparities in #research. #aha22
We need to fix it.
Stop by S3156. Dr Knights poster on #disparities in #research. #aha22
We need to fix it.
Also, don’t miss Dr Horne’s poster on #statin and #etoh. S3063
If transaminases are elevated and statins are indicated: keep the statin, abstain from etoh
@Intermountain @KirkKnowlton
#aha22
If transaminases are elevated and statins are indicated: keep the statin, abstain from etoh
@Intermountain @KirkKnowlton
#aha22
1) Welcome to @cardiomet_CE's new series on #lipid management! This is a 10-#tweetorial program, all #accredited, that will cover it all. Our first expert author is Paul Thompson MD @PaulDThompsonMD, esteemed #cardiologist from @hartfordhosp @UConn Med & now @MGHHeartHealth !
2) This #tweetorial, accredited for #CME/CE and intended for #physicians #physicianassociates #nurses #nursepractitioners #pharmacists is supported by an educational grant from Esperion Therapeutics. See faculty disclosures at cardiometabolic-ce.com/disclosures/.
3) @PaulDThompsonMD took on education re mechanisms & use of ezetimibe & bempedoic acid. He proposes a case: 45 ♂️ w/history of inferior wall #MI treated with primary angioplasty.
1) Welcome to @cardiomet_CE's series on #lipid management! This is a 10-#tweetorial program, all #accredited, that will cover IT ALL. The expert author for this module is Robert Giugliano MD @ @rgiugliano, renowned #cardiologist from @BrighamWomens & @harvardmed !
2) This #tweetorial, accredited for #CME/CE and intended for #physicians #physicianassociates #nurses #nursepractitioners #pharmacists is supported by an educational grant from Esperion Therapeutics. See faculty disclosures at cardiometabolic-ce.com/disclosures/.
3) @rgiugliano is going to discuss care of patients taking #statins who still have residual atherosclerotic cardiovascular disease #ASCVD risk.
Don’t miss a new accredited #tweetorial launching TOMORROW here on @cardiomet_CE. #Interventional #cardiologist, #researcher, & #SoMe education leader @DLBHATTMD will be talking all about #aspirin, its role in #cardiovascular wellness & prevention, and new approaches to . . .
. . . formulation and dosing. Don't miss it--FOLLOW US NOW! @cpcannon @AnnMarieNavar @DrM_ODonoghue @DrMarthaGulati @practicalcardio @GuyattGH @DrMauricioCohen @SVRaoMD @ASPCardio @PlateletDoc @stephanamayer @CMichaelGibson @JJheart_doc @DrSheilaSahni @mmamas1973 @Drroxmehran
1) Welcome to an #accredited #tweetorial on the foundational role of #aspirin in #cardiovascular care. There are new approaches to #aspirin formulation & dosing. This program is accredited for 0.50h CE/#CME. I am @DLBHATTMD. #FOAMed #cardiotwitter #medtwitter
Our study within the MetaCardis @FP7_Projects is out in @nature ! “Statin therapy associates with lower prevalence of gut microbiota dysbiosis” @RaesLab @ClementLab #humanmicrobiome #obesity #statin nature.com/articles/s4158… (thread) (1/7)
We explored the gut microbiota of nearly 900 individuals with BMI=[18-73]. While only 4% of lean/overweight participants were carriers of a previously described aberrant community-type (Bact2 enterotype), percentages sharply rose to 18% in obese participants. (2/7)
This dysbiotic enterotype with low microbial load, low diversity, and depleted in the anti-inflammatory Faecalibacterium, was previously detected in up to 78% of patients with IBD rdcu.be/bWz4m and 26% of people with reported depression rdcu.be/bWz3Q (3/7)
1 approach to understanding #covid19 infection is to examine co-morbidities & ask what's common?
Most prevalent Cov19 co-morbs:
1)↗️age
2)Hypertension
3)Diabetes
4)Cardiovascular disease
5)Kidney disease
6)Chronic respiratory disease (esp COPD)
8)Cancers
9)BMI>40
10)♂️>♀️
Most prevalent Cov19 co-morbs:
1)↗️age
2)Hypertension
3)Diabetes
4)Cardiovascular disease
5)Kidney disease
6)Chronic respiratory disease (esp COPD)
8)Cancers
9)BMI>40
10)♂️>♀️
2/
These are diverse diseases & increasing age technically not a disease at all. However, there is at least 1 factor in common among all of the co-morbidities identified thus far:
INFLAMMATION
These are diverse diseases & increasing age technically not a disease at all. However, there is at least 1 factor in common among all of the co-morbidities identified thus far:
INFLAMMATION
3/
A survey of the co-morbidities revealed another commonality; a close association w/ dysregulation of the pro-inflammatory, neutrophil-recruiting cytokine, IL-17A.
IL-17A is made by multiple immune cell types, including lung-resident innate lymphoid cells (ILC3s).
A survey of the co-morbidities revealed another commonality; a close association w/ dysregulation of the pro-inflammatory, neutrophil-recruiting cytokine, IL-17A.
IL-17A is made by multiple immune cell types, including lung-resident innate lymphoid cells (ILC3s).
Considering #statin in 35-y-o man worried about extensive family history of MI+stroke: 2 parents, 3 of 4 sibs.
#Cholesterol 5.8 mM, 224 mg/dl. Subtypes typical for such a total.
Non-smoker. Otherwise average.
[Live-quiz from #orbita-HQ for #cardioTwitter fellows & the curious]
#Cholesterol 5.8 mM, 224 mg/dl. Subtypes typical for such a total.
Non-smoker. Otherwise average.
[Live-quiz from #orbita-HQ for #cardioTwitter fellows & the curious]
Question C2.
First vote was for diet first, and quite right too! That is the guideline, and we must obey.
Natural, organic, eco-friendly and therefore best.
What effect size is a reasonable expectation, for patient and Dr, for the reduction of total cholesterol by diet?
First vote was for diet first, and quite right too! That is the guideline, and we must obey.
Natural, organic, eco-friendly and therefore best.
What effect size is a reasonable expectation, for patient and Dr, for the reduction of total cholesterol by diet?
Question C3.
(currently 0.8 mmol/L in the lead for Question C2)
There are several ways to choose a value. Which did you use?
(currently 0.8 mmol/L in the lead for Question C2)
There are several ways to choose a value. Which did you use?
