Discover and read the best of Twitter Threads about #artemisinin
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Very pleased to present our recent study of #endocytosis in #apicomplexans that draws on #K13 and drug-resistance in #malaria to learn of a highly unusual endocytic machinery in #Toxoplasma with a deep evolutionary origin. biorxiv.org/cgi/content/sh… 
Using the #Plasmodium #artemisinin-resistance genes as initial leads, some proximity proteomics, and a good deal of super-res microscopy, a comprehensive molecular model of endocytic pits integrated into the cell’s complex (IMC) pellicle was achieved.
Remarkably, this superstructure is highly stable with the typically ephemeral proteins rigidly anchored at this site. Even more unusual, the complex is preassembled in daughter cells before the plasma membrane is even recruited. (and yes, Toxo daughter cells ARE gorgeous!)
Taken together, we suggest that artesunate and pyronaridine might be effective drug candidates for use in human patients with COVID-19 and/or influenza, which may co-circulate during this coming winter season.
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
Pyramax is currently conducting clinical trials for covid-19 in South Africa and South Korea.
-South Korea
clinicaltrials.gov/ct2/show/NCT04…
-South Africa
clinicaltrials.gov/ct2/show/NCT04…
-South Korea
clinicaltrials.gov/ct2/show/NCT04…
-South Africa
clinicaltrials.gov/ct2/show/NCT04…
Plz. Look at this.
Pyramax
(Artesunate-pyronaridine)
Pyramax
(Artesunate-pyronaridine)
