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Very pleased to present our recent study of #endocytosis in #apicomplexans that draws on #K13 and drug-resistance in #malaria to learn of a highly unusual endocytic machinery in #Toxoplasma with a deep evolutionary origin. biorxiv.org/cgi/content/sh… 
Using the #Plasmodium #artemisinin-resistance genes as initial leads, some proximity proteomics, and a good deal of super-res microscopy, a comprehensive molecular model of endocytic pits integrated into the cell’s complex (IMC) pellicle was achieved.
Remarkably, this superstructure is highly stable with the typically ephemeral proteins rigidly anchored at this site. Even more unusual, the complex is preassembled in daughter cells before the plasma membrane is even recruited. (and yes, Toxo daughter cells ARE gorgeous!)
