Discover and read the best of Twitter Threads about #FERRITIN
Most recents (5)
Our latest paper describing #universal #CoV vaccine that can protect against #MERSCoV and #SARSCoV is now out in #preprint @YaleMed
Short thread 👇🏼
“Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice” biorxiv.org/content/10.110…
Short thread 👇🏼
“Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice” biorxiv.org/content/10.110…
We were interested in developing vaccination strategies against highly pathogenic human #coronaviruses with epidemic potential. Our previous studies, and those of others, defined the #RBD as a major target of neutralizing antibodies.
#FERRITIN is being widely ordered these days. Let's dive into the details and learn more about this protein. A short thread for those interested. Covers some history, biology and practical aspects about FERRITIN.
1/n
1/n
It was discovered in 1937 by Laufbérger but it wasn't until 1972 that an assay was devised to measure serum ferritin.
Ferritin is present in 2 forms
👉 Intra-cellular (in the cytosol)
👉 Extra-cellular
2/n
Ferritin is present in 2 forms
👉 Intra-cellular (in the cytosol)
👉 Extra-cellular
2/n
It is a ~450kDa protein.
Has 24 subunits of 2 major types
👉 H : gene on chr 11q
👉 L : gene on chr 19q
Serum ferritin has ⬆️ L: H ratio.
3/n
Has 24 subunits of 2 major types
👉 H : gene on chr 11q
👉 L : gene on chr 19q
Serum ferritin has ⬆️ L: H ratio.
3/n
THREAD from the new #bradykinin research (pre-print) from 🇳🇱:
"We propose that the severity of the disease and many deaths are due to a local vascular problem due to activation of B1 receptors on #endothelial cells in the lungs."
#COVID19 #kinins
preprints.org/manuscript/202…
"We propose that the severity of the disease and many deaths are due to a local vascular problem due to activation of B1 receptors on #endothelial cells in the lungs."
#COVID19 #kinins
preprints.org/manuscript/202…
➡️"the B1 receptor on endothelial cells is upregulated by proinflammatory #cytokines
➡️ Without #ACE2 acting as a guardian to inactivate the ligands of B1, the lung environment is prone for local vascular leakage leading to #angioedema"
...
#bradykinin #COVID19
➡️ Without #ACE2 acting as a guardian to inactivate the ligands of B1, the lung environment is prone for local vascular leakage leading to #angioedema"
...
#bradykinin #COVID19
After a 4-day tour of duty here are some pearls:
#COVIDPearl 1: PE and thrombosis are common. Have a low threshold to treat with full dose Lovenox when Ddimers are markedly elevated and you are having difficulty weaning O2, or there is a setback in the patient’s O2 requirement
#COVIDPearl 1: PE and thrombosis are common. Have a low threshold to treat with full dose Lovenox when Ddimers are markedly elevated and you are having difficulty weaning O2, or there is a setback in the patient’s O2 requirement
#COVIDPearl 2. Be prepared to see sky high inflammatory markers including #CRP and #Ferritin. Their magnitude is not as important as their trends.
#COVIDPearl 3: If the #ProCalcitonin and #WBC go up in the setting of worsening oxygenation, think superimposed bacterial pneumonia
Starting a series on clinical Pearls I am gathering in #COVID19 patients based on experiences of many experts
Will add as we go along
Feel free to add your own observations/experiences
#covidclinicalpearls /1
Will add as we go along
Feel free to add your own observations/experiences
#covidclinicalpearls /1
Anosmia is likely the most specific #COVID19 related symptom
30% of patients have anosmia as their 1st symptom
#covidclinicalpearls /2
30% of patients have anosmia as their 1st symptom
#covidclinicalpearls /2
Around 90% of patients have fever.
50% maybe afebrile at the time of presentation
Fever tends to be very resistant to routine measures in hospitalized patients
There is no consensus that NSAIDs are to be avoided in #COVID2019 patients
#covidclinicalpearls /3
50% maybe afebrile at the time of presentation
Fever tends to be very resistant to routine measures in hospitalized patients
There is no consensus that NSAIDs are to be avoided in #COVID2019 patients
#covidclinicalpearls /3
