Discover and read the best of Twitter Threads about #Cells
Most recents (19)
Mitochondria are essential to our overall health and well-being. In addition to producing energy, they regulate many critical processes in the body. (1/11) #mitochondria #energy #health
Mitochondria play a key role in the production and regulation of neurotransmitters. They also help produce key hormones like cortisol, estrogen, and testosterone. (2/11) #mitochondria #hormones #neurotransmitters #neurotwitter
Mitochondria are involved in epigenetics, which is the expression of #genes from the nucleus. They send signals to the nucleus that turn genes on or off. (3/11) #epigenetics #genes #mitochondria
Ageing: an inevitable part of life. Right? Perhaps not! Recent research from @Harvardmed (10.1016/j.cell.2022.12.027) suggests that ageing may be reversible. This exciting new research may help us better understand ageing! Thread→
@joanna_kacprzyk #Ageing #Biology #Cells
@joanna_kacprzyk #Ageing #Biology #Cells
Ageing is a gradual process which occurs at the cellular level in all living things. In humans, this is marked by physical and mental deterioration. Ageing also increases the risk of nearly all diseases. Though thanks to @davidasinclair, there is hope 👏(1/9).
Research published last month in @CellCellPress looked at the cause and potential solutions to ageing. One primary cause of ageing occurs in DNA, though not in the genes themselves (because that would be far too easy!). The changes actually occur at the epigenetic level (2/9).
1/@GraphiteBio presented preclinical results supporting the use of a single-#cell #RNA #sequencing method to assess #gene correction outcomes in #patients treated with nulabeglogene autogedtemcel (nula-cel) - GPH-101. #BioTech #CRISPR #GeneEditing #Genomics $GRPH #ASH22
2/GPH101 (nula-cel) is a #CRISPR #Cas9 #GeneEditing autologous #stem #cell-based #therapy in clinical development aimed to treat #SickleCellDisease. GPH101 is designed to directly correct the underlying mutation, thereby decreasing HbS production & restoring HbA expression #ASH22
3 $GRPH gene correction platform involves editing hematopoietic #stem cells found in the #bonemarrow that develop into various types of #blood #cells. Since red blood cells lose their genomic DNA during maturation-tracking #GeneEditing in mature cells via sequencing is impossible
Are you interested in learning about #bioinformatics and working with #genomic data? Here's a detailed #learning path to get you started:
To build a strong foundation in biology, you'll need to learn about:
The #structure and #function of #cells, including the various #organelles and their roles in the cell. This will help you understand how cells work and how they carry out essential functions such as #metabolism and #energy production.
"Best practices for single-cell histone modification analysis" w/ @VallotCeline @jeanphi_vert and @PPrompsy.
We identify how to analyze scCUT&Tag, from matrix construction, QC, #cells, up to dimension reduction.
paper: biorxiv.org/content/10.110…
code: github.com/vallotlab/benc…
We identify how to analyze scCUT&Tag, from matrix construction, QC, #cells, up to dimension reduction.
paper: biorxiv.org/content/10.110…
code: github.com/vallotlab/benc…
@VallotCeline @jeanphi_vert @PPrompsy We use multiomics assays to evaluate the quality of the representation in a completely unsupervised fashion, by using the kNN-AUC between the two modalities (see openproblems.bio/benchmarks/mul…)
We further look at the 5 most common histone marks on human PBMC and mouse brain data.
We further look at the 5 most common histone marks on human PBMC and mouse brain data.
@VallotCeline @jeanphi_vert @PPrompsy We show that similarly to scATAC-seq, LSI-based methods such as Signac and ChromSCape tend to outperform their competitors.
We further show that enhancing marks (H3K4me1 and H3K27ac) have extremely high agreement with expression data.
We further show that enhancing marks (H3K4me1 and H3K27ac) have extremely high agreement with expression data.
How precise are noisy #morphogen gradients in #tissue #patterning?
It turns out that the positional information they convey to #cells in the #neuraltube is much more accurate than previously estimated!
Our new #devbio paper is out in @NatureComms: rdcu.be/cH8Fx
It turns out that the positional information they convey to #cells in the #neuraltube is much more accurate than previously estimated!
Our new #devbio paper is out in @NatureComms: rdcu.be/cH8Fx
A methodological subtlety has previously led to overestimated positional errors of the morphogen gradients in the mouse neural tube. We reanalysed the noisy gradients and found that the positional information they can convey to cells is actually orders of magnitude more precise.
Also, morphogen gradients in differently sized tissues must not be pooled and rescaled to their mean length, or else an artificial positional error is added.
Daily Bookmarks to GAVNet 10/31/2021 greeneracresvaluenetwork.wordpress.com/2021/10/31/dai…
Adrienne LaFrance on Twitter and TreadReader
threadreaderapp.com/thread/1452591…
#facebook #transparency #profit #MoralCompass #manipulation
threadreaderapp.com/thread/1452591…
#facebook #transparency #profit #MoralCompass #manipulation
SpaceX needs to tame toilet trouble before weekend launch
phys.org/news/2021-10-s…
#SpaceX #nasa #ToiletLeaks #repairs
phys.org/news/2021-10-s…
#SpaceX #nasa #ToiletLeaks #repairs
Daily Bookmarks to GAVNet 06/28/2021 greeneracresvaluenetwork.wordpress.com/2021/06/28/dai…
Economist Julie Nelson Says Much of Economics is a Sham Science
evonomics.com/pretending-har…
#economics #science #principles #normative #mathematics #HumanBehavior
evonomics.com/pretending-har…
#economics #science #principles #normative #mathematics #HumanBehavior
In Defense of Science
steady.substack.com/p/in-defense-o…
#science #nature #universe #trust #knowledge #application #value
steady.substack.com/p/in-defense-o…
#science #nature #universe #trust #knowledge #application #value
Beware of blue check (w/ few exceptions). #UHN offers ice cream & music in exchange for those willing to take 1st experimental injection - w/ emphasis on #children, 12 yrs of age & up.
UHN Partners:
1. BlueRock
2. CCRM
3. Technion
#4IR #Biotech #Vaccines #CndPoli #tdot
UHN Partners:
1. BlueRock
2. CCRM
3. Technion
#4IR #Biotech #Vaccines #CndPoli #tdot
"BlueRock is using its unique cell+gene platform to direct cellular differentiation & #genetically #engineer #cells to create an entirely new generation of cellular medicines in the areas of neurology, cardiology, & #immunology."
#Biotechnology
#Biotech
#Biotechnology
#Biotech
"As damaging as #H5N8 has been to birds, it had never infected people. Until February."
nytimes.com/2021/04/21/sci… #pandemics #risk
nytimes.com/2021/04/21/sci… #pandemics #risk
1/ "The Russian health authorities also tested about 200 of the people involved in the cleanup of the farm in #Astrakhan, using nasal swabs and later blood tests for antibodies. They reported that for the first time, #H5N8 had jumped to people."
2/ "Seven of the workers appeared to have been infected with the virus, although none of them became ill. Only one of those seven cases, however, was confirmed by genetically sequencing the virus."
How do the hundreds of genetic risk-factors for #Schizophrenia actually lead to disease? New work medrxiv.org/content/10.110… from @manoliskellis illuminates the #SingleCell landscape of #Brains from patients with #Schizophrenia and their healthy counterparts🔬🧠🧵1/10
Combining single-nuclear RNA-Seq @10xGenomics, barcode #ing, and multi-level cell-state decomposition, first author Brad Ruzicka et al. identify 20 cell types in the prefrontal cortex of 24 patients with #Schizophrenia and 24 controls 2/10
While most of these #cells have been described before, what's powerful about the approach is that we can now ask: are there specific cell-types that are increased or decreased in numbers in #Schizophrenia patients compared to healthy individuals (great study design) 3/10
Daily Bookmarks to GAVNet 11/04/2020 greeneracresvaluenetwork.wordpress.com/2020/11/04/dai…
To build back better, we will have to reinvent capitalism | World Economic Forum
weforum.org/agenda/2020/07…
#capitalism
weforum.org/agenda/2020/07…
#capitalism
How to understand cells, tissues and organisms as agents with agendas | Aeon Essays
aeon.co/essays/how-to-…
#cells #agents
aeon.co/essays/how-to-…
#cells #agents
Daily Bookmarks to GAVNet 09/09/2020 greeneracresvaluenetwork.wordpress.com/2020/09/09/dai…
We need to shift our focus from competencies to agency | by Esko Kilpi | Medium
medium.com/@EskoKilpi/we-…
#agency #competencies
medium.com/@EskoKilpi/we-…
#agency #competencies
Urbanization - Our World in Data
ourworldindata.org/urbanization
#data #rural #population #world #urban
ourworldindata.org/urbanization
#data #rural #population #world #urban
Daily Bookmarks to GAVNet 09/04/2020 greeneracresvaluenetwork.wordpress.com/2020/09/04/dai…
Daily Bookmarks to GAVNet 08/07/2020 greeneracresvaluenetwork.wordpress.com/2020/08/07/dai…
The Pandemic's Biggest Mystery Is Our Own Immune System - The Atlantic
theatlantic.com/health/archive…
#pandemic #system #immune #mystery
theatlantic.com/health/archive…
#pandemic #system #immune #mystery
In northern China, scientists have found what may be the 2 billion-year-old birthmarks of Earth's first supercontinent
sciencex.com/news/2020-08-n…
#china #geological #earth
sciencex.com/news/2020-08-n…
#china #geological #earth
#Ayurveda #Herbal #real #Tales
1
Saw 64y old #patient with #jaundice and severe #itching all over #body (called #cholestatic #hepatitis) in OPD. Went to 3 other #hospitals prior, always evaluated for #liver and #bileduct #Cancer. Always cancer tests #Negative. Liverbiopsy👇
1
Saw 64y old #patient with #jaundice and severe #itching all over #body (called #cholestatic #hepatitis) in OPD. Went to 3 other #hospitals prior, always evaluated for #liver and #bileduct #Cancer. Always cancer tests #Negative. Liverbiopsy👇
2
Biopsy shows severe #bile stagnation (#cholestasis) in liver #cells and bile-ducts with #inflammation and #swelling of livercells (#hepatocyte) - classical picture of cholestatichepatitis. CT of liver normal, #MRCP (to see bile ducts) - normal #livertwitter #pathology
CAUSE👇
Biopsy shows severe #bile stagnation (#cholestasis) in liver #cells and bile-ducts with #inflammation and #swelling of livercells (#hepatocyte) - classical picture of cholestatichepatitis. CT of liver normal, #MRCP (to see bile ducts) - normal #livertwitter #pathology
CAUSE👇
3
Patient has #diabetes. Tired of #insulin #diet control. #Ayurvedic #physician advises - stop insulin, start #natural side effect free #treatment. Gives these #CAPSULE . After 6 months on #tablet - liver injury and symptoms start. #nutrition deprived, sugar controlled. #MedEd
Patient has #diabetes. Tired of #insulin #diet control. #Ayurvedic #physician advises - stop insulin, start #natural side effect free #treatment. Gives these #CAPSULE . After 6 months on #tablet - liver injury and symptoms start. #nutrition deprived, sugar controlled. #MedEd
#Ayurvedic treatment of fatty #liver – real world evidence: A #Thread
1/n
Overweight woman, early 40’s. Routine liver tests, mild enzyme abnormalities. Advised #ultrasound liver, showed grade 2 #fattyliver. GP advised vitaminE and #weightloss, review in 3mo
#livertwitter
1/n
Overweight woman, early 40’s. Routine liver tests, mild enzyme abnormalities. Advised #ultrasound liver, showed grade 2 #fattyliver. GP advised vitaminE and #weightloss, review in 3mo
#livertwitter
2/n
Patient and husband doubtful. Hears fatty liver disease can lead to #cirrhosis. Seeks advice from #Ayurvedic practitioner nearby #home since #Herbal #DRUGS = safe. Assures complete #cure through #Ayurveda. Prescribes multiple #medicines, advises almost all foods restriction.
Patient and husband doubtful. Hears fatty liver disease can lead to #cirrhosis. Seeks advice from #Ayurvedic practitioner nearby #home since #Herbal #DRUGS = safe. Assures complete #cure through #Ayurveda. Prescribes multiple #medicines, advises almost all foods restriction.
3/n
Lets look at medicines. #tablet APFIL. Packet mentions ‘for liver #diseases’. Which liver disease? There is #alcohol related, #hepatitis B/C, #NAFLD, primary biliary #cholangitis and more causes. Nine #herbs extract combo - clinical #evidence on safety and benefit ❌
Lets look at medicines. #tablet APFIL. Packet mentions ‘for liver #diseases’. Which liver disease? There is #alcohol related, #hepatitis B/C, #NAFLD, primary biliary #cholangitis and more causes. Nine #herbs extract combo - clinical #evidence on safety and benefit ❌
Daily Bookmarks to GAVNet 7/02/2020-2
greeneracresvaluenetwork.wordpress.com/2020/07/02/dai…
Nathaniel Cline and Nathan Tankus: Fiscal Systems, Organizational Capacity, and Crisis: A Political Balance of Payments Approach
nakedcapitalism.com/2013/05/nathan…
#crisis #payments #balance #systems #capitalism #capacity
greeneracresvaluenetwork.wordpress.com/2020/07/02/dai…
Nathaniel Cline and Nathan Tankus: Fiscal Systems, Organizational Capacity, and Crisis: A Political Balance of Payments Approach
nakedcapitalism.com/2013/05/nathan…
#crisis #payments #balance #systems #capitalism #capacity
We might finally know why the coronavirus spread is out of control again
bgr.com/2020/06/30/cor…
#coronavirus #spread
bgr.com/2020/06/30/cor…
#coronavirus #spread
Did protests drive more Covid-19 cases? New research reveals a surprising answer
inverse.com/mind-body/covi…
#COVID19Cases #research #protests
inverse.com/mind-body/covi…
#COVID19Cases #research #protests
#BlackBirderWeek Day 2 is full of folks doing great #scicom & communication about what the #BlackInNature experience means.
Just a few highlights below!
Just a few highlights below!
#TIL during #BlackBirderWeek
1) Paleohistology is a really cool field! Check out @Yara_Haridy 's blog & short clip introducing #fossil remnants of #cells ()
1) Paleohistology is a really cool field! Check out @Yara_Haridy 's blog & short clip introducing #fossil remnants of #cells ()
#TIL during #BlackBirderWeek
2) More about the #BlackBirder & #BlackInNature experience from @bellzisbirding ()
2) More about the #BlackBirder & #BlackInNature experience from @bellzisbirding ()
