Discover and read the best of Twitter Threads about #realtimechem
Most recents (11)
(1/25) I am writing this thread concerning grad student life in organic synthesis. Some folks will agree with it (though perhaps not openly). Others may be very upset. Either way is OK. But here are some stories, thoughts, and advice
#chemtwitter #realtimechem @RealTimeChem
#chemtwitter #realtimechem @RealTimeChem
(2/25) I began grad school in June 2004, working in the lab of (now retired) Prof. James A. Marshall. He was one of Prof. Ireland’s first graduate students (1957-1960). I joined the Marshall group not because it was easy, but because it was hard. The hard is what made it great
(3/25) Expectations were laid out the first day I arrived. Dr. Marshall was hands off, expected you to generate your own ideas, and understood that lots of reactions don’t work. The PhD is earned by solving problems, and problems won’t fix themselves. You need to put the time in
(1/5) My two cents from someone in the energetic materials arena. Med chem is equivalent to small molecule discovery of new explosive and propellant ingredients. Process chem is the scale-up of these materials for testing purposes.
#chemtwitter #RealTimeChem @RealTimeChem
#chemtwitter #RealTimeChem @RealTimeChem
(2/5) In the discovery phase, cost of reagents, cost of synthesis, and length of the synthesis route aren’t an immediate priority. Goal is to make the new stuff, and get preliminary data to see if it’s even worth scaling-up.
#chemtwitter #RealTimeChem @RealTimeChem
#chemtwitter #RealTimeChem @RealTimeChem
(3/5) If the new energetic fails thermal analysis, is found to be too sensitive to work with, or is incompatible with ingredients it will come into contact with in a formulation, then its dead. This can be determined with little material
#chemtwitter #RealTimeChem @RealTimeChem
#chemtwitter #RealTimeChem @RealTimeChem
(1/25) Having received some DMs on the subject, I would like to tell you all about military technologies, and how they impact our daily lives. This will be a long thread that I hope you’ll read and think about.
#chemtwitter #realtimechem @RealTimeChem
#chemtwitter #realtimechem @RealTimeChem
(2/25) The internet (which originated from the ARPANET), computers, GPS technologies, duct tape, drones, weather radar, microwave ovens, digital cameras, jet engines, synthetic rubber, superglue, canned food, jeep vehicles,
#chemtwitter #RealTimeChem @RealTimeChem
#chemtwitter #RealTimeChem @RealTimeChem
(3/25) The mass production of penicillin, wristwatches, walkie-talkies, night vision, sanitary napkins, freeze drying, the EpiPen, Jerrycans, blood banks and blood transfusions, ambulances, aviator sunglasses, and the entire Space Program
#chemtwitter #reatimechem @RealTimeChem
#chemtwitter #reatimechem @RealTimeChem
So you want to do ammonia-free Birch reductions?
“Large Scale Synthesis of Dysprosium and Neodymium Diiodides” (plus Thulium 💚).
pubs.acs.org/doi/abs/10.102…
A thread #ChemTwitter #RealTimeChem (but from the past). (Table - pubs.acs.org/doi/10.1021/ja…)
“Large Scale Synthesis of Dysprosium and Neodymium Diiodides” (plus Thulium 💚).
pubs.acs.org/doi/abs/10.102…
A thread #ChemTwitter #RealTimeChem (but from the past). (Table - pubs.acs.org/doi/10.1021/ja…)
Divalent lanthanide chemistry is often limited to Sm(II), Eu(II) and Yb(II). Eu(II) is actually stable in degassed water, the other two are oxidized. SmI2 is a powerful reductant used lots in organic chemistry.
Eu(II) has some pretty #Fluorescence!!
Eu(II) has some pretty #Fluorescence!!
Now, Sm, Eu and Yb behave nicely and you can just take the metal carefully with I2 in THF to make [LnI2(THF)5], which can be partially desolvated. In that picture above the inner blue is [EuI2(THF)5], and the outer pale blue is EuI2(THF)2.
You can also use I-C2H4-I, or I2CH2.
You can also use I-C2H4-I, or I2CH2.
Busy days for atmospheric composition over the North Pacific Ocean: high values of total column SO2 & sulphate aerosol from #Nishinoshima🌋 and long-range transport of carbon monoxide at 300hPa (~9km) & smoke aerosol from #Siberia #wildfires. More charts➡️ atmosphere.copernicus.eu/charts/cams/
Find out more about #CopernicusAtmosphere Monitoring Service #OpenData at atmosphere.copernicus.eu
#AtmosChem
#AirPollution
#AirQuality
#RealTimeChem
#AtmosChem
#AirPollution
#AirQuality
#RealTimeChem
When the pandemic lockdown started in March, I did 6 weeks of live-streamed science lessons geared toward k-5th graders. This thread is a recap of them. The video quality isn’t the best because they were uploaded directly from my webcam, but I hope they’re helpful...
#scicomm
#scicomm
Before I recap, you can follow me on IG @sciencemadesimple_llc. Also, I’m posting new science videos every Monday morning this summer on my @youtube channel, like this one from last week about pepper spray, so definitely subscribe:
Lesson 1: We learned about safety, the importance of a lab notebook, and what a hypothesis is. We also did an experiment in order to practice these principles:
Spectroscopy allows us to spy on molecules invisible to the naked eye. Through a cuvette the spectrophotometer allows us to peer and measure concentrations with the help of Beer! 👉 bit.ly/2N4nzXE
#366DaysOfScience #biochemistry #scicomm #realtimechem
#366DaysOfScience #biochemistry #scicomm #realtimechem
The Beer Lambert law (Beer’s law) allows you to convert between concentration (c) of a dissolved thing (solute) & absorbance of light. Don't have a lot - use a NanoDrop so the UV-Vis fun don't stop! bit.ly/beerslawexplai…
#366DaysOfScience #biochemistry #scicomm #realtimechem
#366DaysOfScience #biochemistry #scicomm #realtimechem
Do you listen to your spectrograph peaks when they try to speak? Or just look at highest 1 & assume purification's done? Peakiest peak *might* tell concentration - but rest can reveal contamination! 👉 bit.ly/2NblGc2
#366DaysOfScience #biochemistry #scicomm #realtimechem
#366DaysOfScience #biochemistry #scicomm #realtimechem
Looking for a weekend/holiday read?
Happy to share this major update of our #NeurIPS2019 #ML4PS workshop paper on chemical reaction classificaction (but not only.. 🧪⚗️🌍). @IBMResearch @unibern #compchem #RealTimeChem
Summary thread ⬇️:
Happy to share this major update of our #NeurIPS2019 #ML4PS workshop paper on chemical reaction classificaction (but not only.. 🧪⚗️🌍). @IBMResearch @unibern #compchem #RealTimeChem
Summary thread ⬇️:
We compared different RXN classification methods. 📍Using a BERT model borrowed from NLP, we matched the ground truth (Pistachio, @nmsoftware) with an accuracy of 98.2%.
We did not only visualize what was important for the class predictions by looking at the different attention weights...
In this thread (continued), I am looking back at highly cited (over 1000 citations) 'historical' (prior to 2008) bionano papers, in particular those that deal with nanoparticles & cells. Comments most welcome. #bionano #NanoBubble.
Some background on selection of papers + comments on the first 10 papers here
threadreaderapp.com/thread/1093179…
threadreaderapp.com/thread/1093179…
#11 2005, El-Sayed et al "Surface Plasmon Resonance Scattering and Absorption of anti-EGFR Antibody Conjugated Gold Nanoparticles in Cancer Diagnostics: Applications in Oral Cancer"
doi.org/10.1021/nl0500…
doi.org/10.1021/nl0500…
Our Molecular Transformer paper has been accepted to the ML for Molecules and Materials workshop at #NIPS2018. Looking forward!
Paper: bit.ly/2APtF8I
Platform: rxn.res.ibm.com
@IBMResearch @Cambridge_Uni
#RealTimeChem #Chem4Life #CompChem #RXNforChemistry
Paper: bit.ly/2APtF8I
Platform: rxn.res.ibm.com
@IBMResearch @Cambridge_Uni
#RealTimeChem #Chem4Life #CompChem #RXNforChemistry
Our chemical reaction prediction model was built using OpenNMT @harvardnlp and the #NMT transformer architecture by @ashVaswani et al..
Most of the work would not have been possible without @RDKit_org, @dr_greg_landrum, @nmsoftware and @dan2097. Many thanks!
After a jam-packed 2 days at #SciOut18🌪(thx @ASBMB & @rockedu_!) it was time to reflect! 🤔 Reflection is so important, but it can be hard to find ⏰ to really just think! 💭 Some of my thoughts 👉 instagram.com/p/BokNO_NhihF/
#365DaysOfScience #biochemistry #scicomm #sciout #science
#365DaysOfScience #biochemistry #scicomm #sciout #science
What’s inside? 🧐 It’s FORMAMIDE! 🤗 Formally removing RNA’s form with formamide! 🤓 FORMAMIDE in loading buffer breaks up & replaces the bonds between bases holding RNA's shape together 👇
instagram.com/p/BomwR32B4MX/
#365DaysOfScience #biochemistry #scicomm #lifeinthelab #science
instagram.com/p/BomwR32B4MX/
#365DaysOfScience #biochemistry #scicomm #lifeinthelab #science
Bring on the heat! 🔥 To help denaturants get to the huddling hydrophobic bases, we add heat ♨️ 👉 gives molecules more energy so they can “pull apart” more easily ⏩ easier access 👍 More 👇
instagram.com/p/Boo2yazBDDi/
#365DaysOfScience #biochemistry #scicomm #lifeinthelab #science
instagram.com/p/Boo2yazBDDi/
#365DaysOfScience #biochemistry #scicomm #lifeinthelab #science
