Discover and read the best of Twitter Threads about #plaques
Most recents (3)
1/5 "The analysis revealed that older, #cognitively #healthy #brains showed similar amounts of #dissolvable, #non-#fibrillar #amyloid #protein as #brains of #Alzheimer’s #patients."
#aβ #Aβ #fibrils
gero.usc.edu/2023/01/05/new…
#aβ #Aβ #fibrils
gero.usc.edu/2023/01/05/new…
2/5 "But, as the researchers expected, the brains of #Alzheimer’s patients had higher amounts of #insoluble #Aβ #fibrils, the form of #amyloid #protein that aggregates to form the telltale “#plaques” seen in the #disease,..."
3/5 "... higher levels of #fibrillary #amyloid appear to be a better indicator of #poorer #brain #health."
Are #Amyloid and #Tau #PET positive cognitively unimpaired individuals destined to decline?
Find out in our new preprint: bit.ly/3yXRrOf.
See a thread👇1/11
Find out in our new preprint: bit.ly/3yXRrOf.
See a thread👇1/11
A major unanswered question in the field is whether cognitively unimpaired (CU) individuals who harbor both #Alzheimer’s disease neuropathological hallmarks (abeta #plaques and tau neurofibrillary #tangles) can preserve their #cognition over time or are destined to decline. 2/11
There is fundamental disagreement about the nomenclature. E.g. a CU individual with positive Abeta (A+) and tau (T+) biomarkers is classified as “preclinical AD” by the NIA-AA criteria, while the IWG criteria would label such an individual “at risk for progression to AD”. 3/11
#WeekendLecture
Intracranial Atherosclerotic Disease #ICAD
#ICAD leads to changes ranging from minor wall thickening to #hemodynamically significant luminal stenosis and is one of the most #common causes of #stroke worldwide
ahajournals.org/doi/10.1161/CI…
🧵
Intracranial Atherosclerotic Disease #ICAD
#ICAD leads to changes ranging from minor wall thickening to #hemodynamically significant luminal stenosis and is one of the most #common causes of #stroke worldwide
ahajournals.org/doi/10.1161/CI…
🧵
#WeekendLecture
#ICAD
✅10% of stroke, based on autopsy studies
bit.ly/3v6Lhrd
✅More prevalent in #African Americans, #Hispanics, and #Asians as compared with whites
bit.ly/3AuSiDt
Other risk factors in table
#ICAD
✅10% of stroke, based on autopsy studies
bit.ly/3v6Lhrd
✅More prevalent in #African Americans, #Hispanics, and #Asians as compared with whites
bit.ly/3AuSiDt
Other risk factors in table
#WeekendLecture
#ICAD
In postmortem studies
👉degree of luminal #stenosis
👉% of the plaques containing >40% #lipid area
👉prevalence of intraplaque #hemorrhage, #neovasculature and #thrombus,
were higher in those #plaques associated with #infarct
🔹karger.com/Article/Abstra…
#ICAD
In postmortem studies
👉degree of luminal #stenosis
👉% of the plaques containing >40% #lipid area
👉prevalence of intraplaque #hemorrhage, #neovasculature and #thrombus,
were higher in those #plaques associated with #infarct
🔹karger.com/Article/Abstra…
