Discover and read the best of Twitter Threads about #microglial
Most recents (2)
Our latest paper from @LabMetabolism is out! 🧠🔥
"Changes in mitochondrial morphology modulate LPS-induced loss of #calcium homeostasis in BV-2 microglial cells"
#Metabolism #NeuroTwitter #ImmunoTwitter
1/11
link.springer.com/article/10.100…
"Changes in mitochondrial morphology modulate LPS-induced loss of #calcium homeostasis in BV-2 microglial cells"
#Metabolism #NeuroTwitter #ImmunoTwitter
1/11
link.springer.com/article/10.100…
This was @osvaldo_rpe's first publication and a pretty cool debut indeed!
Osvaldo is a brilliant scientist that I had the honor to co-advise. No doubt I learned from him way way more than I taught.
A well-deserved first-authorship for an undergraduate student! 👏
2/11
Osvaldo is a brilliant scientist that I had the honor to co-advise. No doubt I learned from him way way more than I taught.
A well-deserved first-authorship for an undergraduate student! 👏
2/11
Go, go #mitochondria!
We already knew that microglial activation induces mitochondrial fragmentation and that mito morphology correlates with its Ca2+ uptake
But the influence of mito Ca2+ handling on #microglial activation was still unclear...
3/11
We already knew that microglial activation induces mitochondrial fragmentation and that mito morphology correlates with its Ca2+ uptake
But the influence of mito Ca2+ handling on #microglial activation was still unclear...
3/11
No need for skepticism of #microbiome + virome involvement in #ME/CFS 👉 But we must factor in the activity of organisms (bacteria, viruses, phages, fungi etc) that often persist + interact outside the gut☝️And many such organisms are not “good” but are pathogens/#pathobionts
In fact, Komaroff asked if anyone has a model for #ME/CFS that links together many findings recently presented at #MECFSatNIH19 👉 Well, that’s what my recent paper on ME/CFS does!...w/ #microbiome + virome activity central to how separate findings connect:frontiersin.org/articles/10.33… 
That is b/c 👉 Humans are now understood to be #holobionts: our activity is controlled by the human genome, our microbial/#viral genomes and their respective proteins + metabolites working in tandem (together!): nph.onlinelibrary.wiley.com/doi/full/10.11…
