Discover and read the best of Twitter Threads about #metabolic
Most recents (24)
1/
So you’re interested in #metabolic health and can see the benefits of making a change, but you're not sure where to begin your journey.
I suggest a two-step approach: researching for general awareness, then seeking certified coaching.
🧵
So you’re interested in #metabolic health and can see the benefits of making a change, but you're not sure where to begin your journey.
I suggest a two-step approach: researching for general awareness, then seeking certified coaching.
🧵
2/ The most basic definition of #metabolichealth is the creation and management of energy. But only 12% of Americans fall into that category. 88% are metabolically unhealthy.
Planning and direction are critical to future success, which is where
Planning and direction are critical to future success, which is where
3/ Metabolic coaches work in an industry related to #healthcare, and have spent years refining their approach to wellness.
Since coaching can be accomplished virtually, it's efficient and convenient for those who are unable to travel or don't have time to visit in-person.
Since coaching can be accomplished virtually, it's efficient and convenient for those who are unable to travel or don't have time to visit in-person.
Research suggests that these changes in cognitive function (#brain fog, poor memory, mood, and focus) may be accompanied by dysfunction in #brain energy metabolism that can be treated with #metabolic therapies. (1/17)
Cognitive dysfunction can arise when the brain's energy supply is disrupted. It's called brain hypometabolism. (2/17)
Head traumas and concussions in sports or accidents are associated with such changes and can cause behavioral changes and memory loss in adults. But you don't need a history of head injury for cognitive decline to occur. (3/17)
So what's the difference between nutritional psychiatry and metabolic psychiatry?🧵(1/6)
#Metabolicpsychiatry is a subfield that focuses on the assessment and treatment of metabolic dysfunction as a means to improve #mentalhealth. (2/6)
There is a complex but crucial relationship between #metabolic dysfunction, food, and mental health. (3/6)
The blood-brain barrier (BBB) is a crucial defense mechanism for the brain, regulating the exchange of molecules between the bloodstream and the brain. When the BBB is disrupted, it can have severe consequences for brain health. (1/12)
Alzheimer's disease is one example of a condition that is exacerbated by BBB disruption. When the BBB is compromised, amyloid beta-peptide deposits can accumulate, leading to #inflammation and disruption of neuronal function. (2/12)
A disrupted BBB in #Alzheimers means astrocyte and microglia inflammation, disruption of synaptic transmission, and myelin destruction. (3/12)
I teach people how to use a ketogenic diet to help with mood and cognitive dysfunction. But that is just the first phase in my online program toward their recovery. (1/10)
Phase 2 consists of teaching people how to do a nutrigenomics analysis for truly personalized supplementation. What is nutrigenomics and why do I think this step is important? (2/10)
Nutrigenomics explores how your genes interact with different foods and nutrients. It can inform you if you may benefit from different types, forms of supplements that improve mitochondrial function. (3/10)
I am sure many of you know who @davidludwigmd is, but just in case you are brand spanking new to the low-carb space, I want you to know who he is and that he was at the Metabolic Psychiatry Retreat put on by @janellison and @Metabolic_Mind this year! 🧵(1/8)
#metabolicpsychiatry
#metabolicpsychiatry
@davidludwigmd @janellison @Metabolic_Mind Dr. David S. Ludwig is an endocrinologist and researcher at Boston Children’s Hospital (@BostonChildrens), Professor of Pediatrics at Harvard Medical School (@harvardmed), and Professor of Nutrition at Harvard School of Public Health (@HarvardChanSPH). (2/8)
@davidludwigmd @janellison @Metabolic_Mind @BostonChildrens @harvardmed @HarvardChanSPH For more than 25 years, Dr. Ludwig has studied the effects of dietary composition on metabolism, body weight, and risk for chronic disease – with a special focus on low-glycemic index, low-carbohydrate, and ketogenic diets. (3/8)
Migraine, a common neurological disorder, may be a metabolic as much as a neurological disease, with the migraine attack serving as a warning signal to increased oxidative stress and/or hypometabolism. (1/21) #neurotwitter #hypometabolism
Despite being primarily studied in terms of neuro-vasculature and neurotransmission, recent research suggests that migraine's pathogenic mechanisms may be linked to metabolism and mitochondrial dysfunction. (2/21) #mitochondria
Magnetic resonance spectroscopy studies have consistently shown decreased ATP levels and abnormal mitochondrial function in migraineurs, suggesting a metabolic component to the disorder. (3/21)
We are discovering exciting things about how therapeutic nutritional ketosis could benefit those living with serious mental illnesses. It's time for a short thread about two main ways this could be happening. 🧵 (1/13)
First is the direct effect of ketones. Scientific studies have shown that people with serious mental illnesses often have trouble using glucose efficiently for fuel. Ketones supply fuel that doesn't depend on insulin or the cell's ability to metabolize glucose. (2/13)
By providing the brain with this alternative fuel source, ketones can help enhance energy production and improve cognitive function in people with serious mental illnesses. (3/13) #lifechanging
Can a ketogenic diet help the symptoms of a hard-core neurodegenerative disorder like Huntington's disease? Let's see what a published case study found. 🧵 (1/16)
Huntington's disease (HD) is a genetic disorder caused by a mutation in the huntingtin (HTT) gene, which produces a toxic protein that damages nerve cells in the brain. (2/16)
HD is inherited in an autosomal dominant pattern, meaning that a person only needs one copy of the mutated gene from either parent to develop the disease. (3/16)
Many people with mental health conditions rely on medications to manage their symptoms, but these medications often come with metabolic side effects like weight gain, type 2 diabetes, and sexual side effects. (1/8)
Many people complain of feeling less "bad" but also emotionally flat. As someone who does couples therapy, I can tell you these side effects come into the session with the couple.
There are costs to these side effects. (2/8)
There are costs to these side effects. (2/8)
In addition to the financial cost of medications, these side effects can come at a high quality-of-life cost, which is why many people don't stay on them, even when they're helpful. (3/8)
Insulin receptors and IGF-1 receptors, along with their signaling partners, are found throughout the brain. I think this needs a thread. 🧵(1/13)
IGF-1 receptors are involved in important #brain processes, including neuronal growth and survival, regulation of synaptic plasticity, and modulation of #neurotransmitter release. They are implicated in neuroprotection and #cognitive function. (2/13) #science #neuroscience
Many of you are familiar with insulin, but maybe you don't know well enough what its important roles are in the brain. Insulin affects neurotransmitter channel activity, brain cholesterol synthesis, and mitochondrial function. (3/13) #mitochondria
1/5 As many of you here watch family, friends, associates and colleagues living their best lives out there, as #COVID19 surges, please know that many ARE NOT okay.
"Psychoanalyst Judith Alpert theorizes that our culture is terrified of death, illness, and vulnerability."
"Psychoanalyst Judith Alpert theorizes that our culture is terrified of death, illness, and vulnerability."
2/5 "Thus, “[t]hose who have contact with the #chronically #ill . . . do not want to be #reminded of #vulnerability and #ultimate #demise. In turn, the demand placed on the chronically ill is to #control, #hide, and #overcome the #chronic #illness.” (Alpert, 2012)."
3/5 Many of those who appear to be living their best lives are faking wellness to fit in.
psychologytoday.com/us/blog/chroni…
psychologytoday.com/us/blog/chroni…
Let’s talk about #mitochondria and #mentalhealth. Specifically, mitochondrial dysfunction…
Mitochondrial dysfunction is the term most frequently used to describe impairment in mitochondrial function. 🧵
Mitochondrial dysfunction is the term most frequently used to describe impairment in mitochondrial function. 🧵
The diseases and illnesses that have been associated with mitochondrial dysfunction are widespread, and the list includes almost all of the psychiatric disorders.
It also includes the metabolic and neurological disorders such as obesity, diabetes, cardiovascular disease, Alzheimer’s disease, epilepsy, many cancers and Parkinson’s disease, and more…
1) Welcome to a new #accredited (0.75h CE/#CME) #tweetorial on challenging case presentations for pts with #cardiometabolic disease, #CaReMe #FOAMed.
Our expert author is Claire Davies. @claireyrivs is a specialist diabetes & endocrinology #pharmacist working in Gateshead in 🇬🇧.
Our expert author is Claire Davies. @claireyrivs is a specialist diabetes & endocrinology #pharmacist working in Gateshead in 🇬🇧.
2) She is a member of UKCPA Diabetes & Endocrinology committee @UKCPADiabetes & works across #diabetes, #endocrinology, & emergency/acute care in Secondary Care. She is currently involved in development of regional guidelines & education to support medicines optimisation for PLWD
3a) This program is intended for healthcare professionals and is supported by an educational grant from Boehringer Ingelheim Pharmaceuticals Inc. and Eli Lilly Company.
📢 Very 🔥 out of press!
Our paper about #metabolic reprogramming in DC during development and activation.
OPEN ! (enjoy) nature.com/articles/s4146…
#natcomms
DC can 🔥 or🧯adaptive immune responses (IR). Also Metabolism can 🔥 or🧯 IR.
Little "zoom" on this story:👇
🧵
Our paper about #metabolic reprogramming in DC during development and activation.
OPEN ! (enjoy) nature.com/articles/s4146…
#natcomms
DC can 🔥 or🧯adaptive immune responses (IR). Also Metabolism can 🔥 or🧯 IR.
Little "zoom" on this story:👇
🧵
🤔 What are the metabolic profiles associated to inflammatory🔥 and tolerogenic 🧯👫 monocyte derived DCs?
Tools 🛠️ developed by us @SCENITHmetab (@CIML_Immunology), @felixjhartmann and others allowed us to address those questions.
(SCENITH)
Tools 🛠️ developed by us @SCENITHmetab (@CIML_Immunology), @felixjhartmann and others allowed us to address those questions.
(SCENITH)
👆
- A dramatic metabolic switch in monocytes one day after they start differentiation (top right).
Also:
How metabolic heterogeneity links to surface markers heterogeneity by #SCENITH (@SCENITHmetab & #scMEP in 🧯or 🔥 conditions
Check the nature.com/articles/s4146…
....
- A dramatic metabolic switch in monocytes one day after they start differentiation (top right).
Also:
How metabolic heterogeneity links to surface markers heterogeneity by #SCENITH (@SCENITHmetab & #scMEP in 🧯or 🔥 conditions
Check the nature.com/articles/s4146…
....
Many people ask - I'm eating what my grandparents ate. They were vegetarians & were (mostly) healthy & slim.
Why do I have #metabolic issues? Why should I change my food?
(I'm referring to 👵🧓 before the 1980-90s era)
Consider these answers (A THREAD)
👇🏽
Why do I have #metabolic issues? Why should I change my food?
(I'm referring to 👵🧓 before the 1980-90s era)
Consider these answers (A THREAD)
👇🏽
1. NO FOOD MILES & CLEAN EATING
Have you seen them eat from a hotel? Or buy from a shop?
They always ate locally sourced items, home cooked simple meals. Grains, Fruits & veggies didn't have the amount of #pesticides that are found today.
Have you seen them eat from a hotel? Or buy from a shop?
They always ate locally sourced items, home cooked simple meals. Grains, Fruits & veggies didn't have the amount of #pesticides that are found today.
2. SUGARS & TREATS FOR SPECIAL OCCASSIONS
Sugary food, snacks & treats were mainly reserved for special occasions & feasting times. They were NOT an everyday item.
Sugary food, snacks & treats were mainly reserved for special occasions & feasting times. They were NOT an everyday item.
Welcome everyone to our 2nd Pediatric on Squares Board Review Course
We are starting today until the coming 8 days
Hope it’ll be helpful and enjoyable course
✏️ Note that you still can join and register on the course with accessibility to all recorded session until 27th of August
We are starting today until the coming 8 days
Hope it’ll be helpful and enjoyable course
✏️ Note that you still can join and register on the course with accessibility to all recorded session until 27th of August
Day 1
2nd session: Keys to Answer MCQs
3rd session: Neonatology review
By: Prof. Abdulrahman Alnemari @aalnemri
#Pediatric #Neonatology #NICU #MCQ
2nd session: Keys to Answer MCQs
3rd session: Neonatology review
By: Prof. Abdulrahman Alnemari @aalnemri
#Pediatric #Neonatology #NICU #MCQ
"Argument-Making in the Wild"
Today's SFI Seminar by Simon DeDeo (@LaboratoryMinds), streaming now. Follow our thread for pull quotes and slides:
Today's SFI Seminar by Simon DeDeo (@LaboratoryMinds), streaming now. Follow our thread for pull quotes and slides:
First, let's divide human history into three eras, or regimes of #knowledge #production and #consumption:
• #premodern/#archaic
• #modern + #postmodern
• the #egregore (online content sharing)
• #premodern/#archaic
• #modern + #postmodern
• the #egregore (online content sharing)
• The premodern era is defined by caloric restriction.
• The modern era is characterized by a small number of sellers of #information vs. a large number of consumers (see also #HerbertSimon's remarks on the "poverty of #attention")
• The modern era is characterized by a small number of sellers of #information vs. a large number of consumers (see also #HerbertSimon's remarks on the "poverty of #attention")
..many people debate the various ratios of #macronutrients like #protein, #fat, and #carbohydrates in their diet to find their optimal health. Which is great as we are #bioindividuals but most miss out on #micronutrients like #vitamins and #minerals.
The way our bodies are able to use the #macronutrients is fully dependent on how our #enzymatic pathways are influenced by various #micronutrients. One of the most important amongst is #magnesium.
1/N "back-of-the-envelope" list of reasons why #UrgencyOfNormal is INHUMANE...
1. #denial of #SARS_COV_2 #origins
2. #supression of #earlytreatment, #athome #treatment
3. #denial of #airborne #transmission
4. Denial of #urgency of #airborne #precautions
5. #oversold #immunity
1. #denial of #SARS_COV_2 #origins
2. #supression of #earlytreatment, #athome #treatment
3. #denial of #airborne #transmission
4. Denial of #urgency of #airborne #precautions
5. #oversold #immunity
2/N
6. #fabricated #superimmunity, #wallofimmunity, #herdimmunity, & #herdresistance
7. #unmitigated #transmission & #breakthroughinfections breeding #more #infectious #variants
8. #Mischaracterization of breakthrough #infections as "#rare"
9. #denial of #risk of #longcovid
6. #fabricated #superimmunity, #wallofimmunity, #herdimmunity, & #herdresistance
7. #unmitigated #transmission & #breakthroughinfections breeding #more #infectious #variants
8. #Mischaracterization of breakthrough #infections as "#rare"
9. #denial of #risk of #longcovid
3/N
10. Rampant #Gaslighting of #longcovid victims, inadequate #treatment
11. Rampant #latent long #COVID19
12. #rampant #metabolic #dysregulation & #dybiosis
13. #denial of #airborne transmission
14. #lack of #preparedness in #pandemic & #global #bioweapon #attack #management
10. Rampant #Gaslighting of #longcovid victims, inadequate #treatment
11. Rampant #latent long #COVID19
12. #rampant #metabolic #dysregulation & #dybiosis
13. #denial of #airborne transmission
14. #lack of #preparedness in #pandemic & #global #bioweapon #attack #management
Picking up where @rita_rebollo left, we spent a couple of years annotating and analyzing the rest of the rice #weevil #genome (ok, the 15% left after removing repeats)! All info presented here is on the huge Additional file 2 in @BMCBiology doi.org/10.1186/s12915… 1/n
@VargasChavezC and @gabaldonlab performed a comprehensive #phylogenomic analysis of the rice #weevil and found that this insect has a high gene expansion rate when compared to other beetles. 2/n
With the invaluable help of the SymT group from @INRAE_UMR_BF2I we have also reconstructed the #metabolic pathways from both #symbiotic partners. Specific losses of enzymes in the #weevil genome are limited while its #endosymbiont has suffered much more degradation. 3/n
In our recent review on #LongCovid/PASC we bring up the possibility that dysbiosis or imbalance of host #microbiome communities (in ecosytems such as the gut, lungs, or oral cavity) might contribute to at least some LongCovid symptoms: frontiersin.org/articles/10.33…
2/ More specifically immune dysregulation driven by #SARS-CoV-2 might allow pathobionts (bacteria capable of both commensal + virulent acitivty) in the gut, mouth, or other body sites to collectively shift towards a state of imbalance + pro-inflammatory gene/metabolite expression
3/ Conversely, b/c composition + activity of the microbiome can influence host susceptibility and ongoing control of #viral pathogens, exisiting microbiome dysbiosis in a range of body sites may serve as a form of predisposition to LongCovid
This interesting study found that skeletal #muscle cells of #ME/CFS patients showed a decrease in oxidative phosphorylation (a metabolic pathway used by #mitochondria to generate #energy). In simple terms, that caused the cells to have a dysregulated #metabolism.
2/ Not mentioned in the paper, but important to consider, is that most well-studied #viral + bacterial #pathogens “hijack” the metabolism of the cells they infect in a manner that can result in decreased oxidative phosphorylation (or similar changes in cell energy pathways).
3/ In simples terms, these #pathogens “hijack” cell metabolism to “pull” substrates out of the human mitochondrial energy pathways...and use the substrates (lipids, fatty acids, amino acids) for their own #nutritional and replication purposes!
Excited to share our publication on #inflammation, #metabolic dysregulation, & #depression symptoms now out @JAMAPsych!
This is work by @Binder_Lab, Janine Arloth, @mgeorgakis1, @and_Ramses_II, Symen Ligthart, & @golam_khandaker.
Tweetorial below
jamanetwork.com/journals/jamap…
This is work by @Binder_Lab, Janine Arloth, @mgeorgakis1, @and_Ramses_II, Symen Ligthart, & @golam_khandaker.
Tweetorial below
jamanetwork.com/journals/jamap…
In this project we studied symptom heterogeneity in #depression, which is highly prevalent and may hamper ongoing research efforts in depression. @caina89, @karmelchoi, & @EikoFried have recently conducted an excellent review on the genetic side of this:
academic.oup.com/hmg/article/29…
academic.oup.com/hmg/article/29…
In our study, we focused on the association of #inflammation w/ specific depressive symptoms, which was previously largely described in cross-sectional studies, but also some longitudinal & polygenic risk score work.
