Discover and read the best of Twitter Threads about #glia
Most recents (8)
Both neighborhood and family #socioeconomic status (SES) influence children’s gray matter structure & function, but what about #whitematter (WM)? What could be some mediating mechanisms? We studied these questions in 8842 children from the #ABCD Study: medrxiv.org/content/10.110…
RSI assessed microstructure in 31 WM tracts. We looked at RND, which measured *directional* intracellular water & could reflect organized #myelin, and RNI, which measured *isotropic* intercellular water & could reflect #glia/neuron cell bodies. (fig adapted Burnor et al 2021) 
Higher neighborhood disadvantage and lower parental education had independent links to lower RND (organized myelin) in forceps maj, corticospinal tract, and sup long fasciculus. These agree with previous findings of lower DTI-FA and lower WM integrity in low SES.
The Unique Regulation of Glucose and Ketosis in the Brain 🧵(1/4)
Regulatory controls are tighter in the brain than in the periphery. Glucose and glycogen regulation happens in the glia in the brain. #glia (2/4)
Ketosis can take 24-36 hours to achieve in the periphery, but the brain goes into ketosis every night. Glial glycogen stores are depleted within 6-8 hours. #ketones (3/4)
1/13
A 🧵on our work on the role of #glia in #MECFS
frontiersin.org/articles/10.33…
Our paper explains why ME/CFS research may benefit from a closer look at the role of the immune system of the brain.
A 🧵on our work on the role of #glia in #MECFS
frontiersin.org/articles/10.33…
Our paper explains why ME/CFS research may benefit from a closer look at the role of the immune system of the brain.
2/13
Many things are known about the pathobiology of ME/CFS. There is evidence for (e.g.):
- immune dysfx
- metabolic / mitochondrial / peroxisomal dysfx
- endothelial / vascular dysfx
- dysfunction of the autonomous nervous system
and the CNS in general
Many things are known about the pathobiology of ME/CFS. There is evidence for (e.g.):
- immune dysfx
- metabolic / mitochondrial / peroxisomal dysfx
- endothelial / vascular dysfx
- dysfunction of the autonomous nervous system
and the CNS in general
3/13
How do the latter dysfunctions fit together and how do they conspire to cause the symptoms of ME/CFS?
Our hypothesis: these processes can affect a very important regulatory system of our biology: the innate immune system of our brain.
How do the latter dysfunctions fit together and how do they conspire to cause the symptoms of ME/CFS?
Our hypothesis: these processes can affect a very important regulatory system of our biology: the innate immune system of our brain.
Awesome study used mice + human brain organiod model to show #COVID-19 can infect the CNS/#brain, where it specifically infected radial #glia, neural stem cells + #neurons. The #virus altered the #metabolism of the neurons it infected + cld use neuron cell machinery to replicate
2/ It’s not surprising that #COVID-19 can infect neurons given the nasal cavity is connected to the #CNS via the cribriform plate, olfactory epithelium + #nerve. This led the team to state that “the brain should be considered a high-risk organ system upon #respiratory exposure”
3/ The team also showed that, at least in some #COVID-19 patients w/ #neurological symptoms, there is a robust antibody response to the #virus in the #cerebrospinal fluid (CSF). In fact, CSF-containing antiviral #antibodies blocked COVID-19 infection in brain organoids
Sharing my #Story as an #iws, as part of @IWS_Network #Voices without #Frontiers program! #IWS #VoicesIWS #WomenInSTEM
My story starts in a small town from the northern region of the warm vibrant and culturally diverse #India.
#VoicesIWS
#VoicesIWS
Born as 3rd daughter in a culture where birth of a daughter is resented by many, my parents had to deal with 'eerie' solutions from society to get rid of the "burden" that I was about to become. But, my visionary parent-warriors had their armours on! 😇
#genderbias #VoicesIWS
#genderbias #VoicesIWS
#Ciencia más allá de #coronavirus: La edición de junio de la revista científica #Glia eligió una imagen generada por el Laboratorio de Neurodegeneración del @IPMontevideo para su portada. En este #hilo te contamos por qué esta foto de células del sistema nervioso merece la tapa:
En la foto, células del sistema inmune (en rojo) fagocitan (ingieren) mielina (gris/blanco), sustancia que cubre las prolongaciones de neuronas motoras. Esto ocurre en las enfermedades neurodegenerativas, y hace que las
neuronas pierden la capacidad de comunicarse.
neuronas pierden la capacidad de comunicarse.
En los nervios, las llamadas "células de Schwann" producen la mielina que cubre y protege a las terminaciones neuronales. Cuando hay un daño, estas
células liberan sustancias para ayudar a repararlo. Pero a veces eso se descontrola y el sistema inmune termina dañando los nervios.
células liberan sustancias para ayudar a repararlo. Pero a veces eso se descontrola y el sistema inmune termina dañando los nervios.
@AchucarroGlia organises an innovative concept of advanced training course for researchers focused or willing to work in the vibrant field of glial cells #GLIA #gliaSchool2020 🧠 🔍
Thread 👇
Thread 👇
This School fosters close interactions between speakers and attendees during three intense days.
With 🧬Practical 🧪 demonstrations of 🔬techniques and 📙 Brainstorming sessions. #gliaSchool2020
With 🧬Practical 🧪 demonstrations of 🔬techniques and 📙 Brainstorming sessions. #gliaSchool2020
#Euroglia 2019 in #Porto (PT) has just published the Meeting Program.
Very much looking forward to be there! #GliaMeeting #NetworkGlia #glia
glia2019.eu/_medien/_conte…
Very much looking forward to be there! #GliaMeeting #NetworkGlia #glia
glia2019.eu/_medien/_conte…
New in this edition:
To promote interactions between speakers and attendants, the program includes a session called “meet the speakers”. The sessions will take place during the lunch breaks from Thursday to Saturday; glia2019.eu/?s=meet-the-sp…
To promote interactions between speakers and attendants, the program includes a session called “meet the speakers”. The sessions will take place during the lunch breaks from Thursday to Saturday; glia2019.eu/?s=meet-the-sp…
What about the Posters in #Euroglia 2019 ??
