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Both neighborhood and family #socioeconomic status (SES) influence children’s gray matter structure & function, but what about #whitematter (WM)? What could be some mediating mechanisms? We studied these questions in 8842 children from the #ABCD Study: medrxiv.org/content/10.110…
RSI assessed microstructure in 31 WM tracts. We looked at RND, which measured *directional* intracellular water & could reflect organized #myelin, and RNI, which measured *isotropic* intercellular water & could reflect #glia/neuron cell bodies. (fig adapted Burnor et al 2021) 
Higher neighborhood disadvantage and lower parental education had independent links to lower RND (organized myelin) in forceps maj, corticospinal tract, and sup long fasciculus. These agree with previous findings of lower DTI-FA and lower WM integrity in low SES.
