Discover and read the best of Twitter Threads about #cerebrospinal
Most recents (2)
Awesome study used mice + human brain organiod model to show #COVID-19 can infect the CNS/#brain, where it specifically infected radial #glia, neural stem cells + #neurons. The #virus altered the #metabolism of the neurons it infected + cld use neuron cell machinery to replicate
2/ It’s not surprising that #COVID-19 can infect neurons given the nasal cavity is connected to the #CNS via the cribriform plate, olfactory epithelium + #nerve. This led the team to state that “the brain should be considered a high-risk organ system upon #respiratory exposure”
3/ The team also showed that, at least in some #COVID-19 patients w/ #neurological symptoms, there is a robust antibody response to the #virus in the #cerebrospinal fluid (CSF). In fact, CSF-containing antiviral #antibodies blocked COVID-19 infection in brain organoids
Not to mention that factoring the #microbiome/virome (+ the #pathogens that end up persisting in these communities!) into #ME/CFS 👉 allows “unique #infectious history” to factor into disease progression (w/ #chemical exposures/stress etc facilitaring pathogen persistence) 
Also keep in mind pathogens can persist in #latent forms 👉 Eg: here Zika was shown capable of persisting in the #cerebrospinal fluid + lymph nodes of monkeys for months after the #virus had been cleared from peripheral blood and urine: sciencedirect.com/science/articl…
Ok that’s it for now 😅 Thanks for reading!
