Discover and read the best of Twitter Threads about #cytokinestorm
Most recents (17)
1) How I cured my #LongCovid in 3mos after suffering for almost a year. This was my last hope. I researched what #Covid does to the body, came up with a list of "clinically studied" supplements and...
2) took them all. Firstly, I am not a MD. In March 2021 I caught Covid while working as a #frontline #healthcare worker. My symptoms of #brainfog, #fatigue, #jointpain, #muscleweakness, morning #stiffness happened after my recovery. At the time, this #postcovid #syndrome was...
3) was just starting to be discussed online. The the term #Longhauler was coined. Those in the #ME, #CFS, #Lyme #MCAS #community starting speaking out about the similarity of #symptoms with #LC. #Covidclinics started to sprout up, include one at the....
'Endemic Delusion' in Denmark - coming to a continent / country / city / town / village / house near you, if it isn't already in your living-room.
#FarFromNormal
#P100
#ElastomericBulletproof
Q & A.
Not sure why anyone would focus on one particular continent when this happens to be a global pandemic.
When Pi?
#ButtonUp #N95 #FFP3 #GoElastomeric #P100
This is how it's done. Humanity at work, finally.
Italy gets it.
#MasksInSchools #MasksSaveLives #MasksSaveBrainDamage
My mom was hospitalized with low O2 (82) and inability to standup due to fainting (hypoxia) due to #coronavirus on Day 8 of her infection last Sunday, 12/20.
She received #Ivermectin and Dexa and a mild steroid. She received 2nd round of #Ivermectin Tues.
Symptoms ~70% better
She received #Ivermectin and Dexa and a mild steroid. She received 2nd round of #Ivermectin Tues.
Symptoms ~70% better
Since #Ivermectin, She has recovered her sense of taste and smell.
No more rigor (shaking) due to probable #coronavirus sepsis.
Fever reduced to 101 F and only @ night.
Cough reduced 90%.
No more sore throat.
Blood O2 @ 92-97 [safe bounds, avg 95], checked hourly.
No more rigor (shaking) due to probable #coronavirus sepsis.
Fever reduced to 101 F and only @ night.
Cough reduced 90%.
No more sore throat.
Blood O2 @ 92-97 [safe bounds, avg 95], checked hourly.
She took it way too late (Day 8 and 10).
For best results take #Ivermectin on exposure or at FIRST SIGN of drainage or throat tickling...
DO NOT WAIT til you're collapsing like my mom did.
For best results take #Ivermectin on exposure or at FIRST SIGN of drainage or throat tickling...
DO NOT WAIT til you're collapsing like my mom did.
#Leronlimab is an antibody that blocks a cell receptor called CCR5. The #CCR5 receptor just happens to be a key doorway HIV uses to get inside a cell so that’s why we developed it as an HIV treatment. But the actual function of CCR5 inside our body is to direct cell movement and
Function. Breast, prostate, and a few other cancers co-opt the immune system to support their growth by using the CCR5 receptor to control cell movement and function. We were targeting that role of CCR5 to support cancer cell growth when COVID-19 hit. Our early signals of success
in breast cancer led us to believe we could impact the inflammation, or #cytokinestorm, that is killing patients with Covid-19 since it is the same cell movement and function controlled by CCR5 that is involved. And, as incredible as it sounds, I believe we got very lucky and
(1/3) Timeline of a #covidiot.
37 yro Richard Rose of Ohio said he thought #coronavirus was "a hoax" and was very pro-Trump and very strong anti-masker, like @SarahConner39.
April 28th: he said this:
37 yro Richard Rose of Ohio said he thought #coronavirus was "a hoax" and was very pro-Trump and very strong anti-masker, like @SarahConner39.
April 28th: he said this:
(2/3) July 1st he became symptomatic and got tested with a rapid test. Confirmed #coronavirus positive.
On 2 July 2020, he posted this:
On 2 July 2020, he posted this:
(3/3) The next day, July 3rd he posted this.
But by July 4th, he was *DEAD*! #CardiacArrest, probably from #CytokineStorm.
This #covidiot learned the hard way that #coronavirus is NOT A JOKE!
dailymail.co.uk/news/article-8…
But by July 4th, he was *DEAD*! #CardiacArrest, probably from #CytokineStorm.
This #covidiot learned the hard way that #coronavirus is NOT A JOKE!
dailymail.co.uk/news/article-8…
A tweet thread.
Subject: Critical appraisal of Itolizumab in #Coronavirus infection.
Events: 1. @sardesairajdeep ran a programme on 11 July showcasing what was claimed to be a breakthrough in the hunt for a drug that worked against #Covid19. Featured #Biocon's @Kiranshaw
Subject: Critical appraisal of Itolizumab in #Coronavirus infection.
Events: 1. @sardesairajdeep ran a programme on 11 July showcasing what was claimed to be a breakthrough in the hunt for a drug that worked against #Covid19. Featured #Biocon's @Kiranshaw
Kiran Mazumdar-Shaw has blocked me so she won't see this thread. You can watch @sardesairajdeep programme here: .
Essentially it explained the #cytokinestorm that happens is some patients with #Covid19 and can be fatal. #Itolizumab counters this.
Essentially it explained the #cytokinestorm that happens is some patients with #Covid19 and can be fatal. #Itolizumab counters this.
What is Itolizumab? Here is it's Wikipedia entry: It is a relatively newly developed drug in a class of drugs known as monoclonal antibodies (all of them end in '-mab'). They have been around as a class of pharmacologic agent since 1986.
offering comprehensive #cytokine profiling (including RANTES levels), to help Drs understand the pathogenesis of Childhood Inflammatory Disease Related to #COVID19 #Leronlimab pdf.reuters.com/htmlnews/htmln…
Recent reports in parts of the U.S. and Europe suggest a rare and potentially fatal inflammatory disease linked to #coronavirus is afflicting a small number of children. #Leronlimab may be able to help calm #CytokineStorm
Condition resembles a rare childhood illness called #KawasakiDisease, which has similar signs and symptoms and can lead to enlargement of blood vessels that in severe forms may cause heart damage. #Leronlimab has shown to help calm #CytokineStorm and maybe good #treatment
"The live SARS-like coronavirus SL-CoV-WIV1 has been isolated for the first time from bat droppings; and such virus has been confirmed to invade the host cells through the ACE2 of human beings..."
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964
In this study, we have developed a fast and cost-effective method
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily.
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily.
Morning peeps 😁 first day without a #wakeandbake time for a tolerance break 😱 wish me luck, gonna do at least 72 hours & then see if I can go any longer 🤞💚🌿🖖
Update on my cannabis tolerance break, having slight issues with muscle spasms/dystonia in my foot 😭
Morning peeps 😁
Day two without a #wakeandbake 😁 Didn’t sleep as well as usual but at least I’ve stopped being sick, couldn’t even keep water down from about 5pm last night 🤢🤮 Still taking my CBD paste though, better safe than sorry #COVIDー19 #COVID19 #cytokinestorm 💚🌿🖖
Day two without a #wakeandbake 😁 Didn’t sleep as well as usual but at least I’ve stopped being sick, couldn’t even keep water down from about 5pm last night 🤢🤮 Still taking my CBD paste though, better safe than sorry #COVIDー19 #COVID19 #cytokinestorm 💚🌿🖖
I have substantially bought #DDDD today
I have done extensive research into #COVID19 treatments companies listed on AIM over the weekend (Around 30 HOURS❗❗) and came to the conclusions DDDD is the drug which is most likely to have great efficacy and safety data 💥💥💥
I have done extensive research into #COVID19 treatments companies listed on AIM over the weekend (Around 30 HOURS❗❗) and came to the conclusions DDDD is the drug which is most likely to have great efficacy and safety data 💥💥💥
#DDDD
The Microbiome Therapeutics company focused on using an innovative solutions for treatment in unmet 21st century ailments
Areas of focus
-Vaccines
-Oncology (Cancer)
-Respiratory illnesses inc
---SARS-CoV-2 #COVID19
-Irritable Bowel Syndrome
-Central Nervous System
The Microbiome Therapeutics company focused on using an innovative solutions for treatment in unmet 21st century ailments
Areas of focus
-Vaccines
-Oncology (Cancer)
-Respiratory illnesses inc
---SARS-CoV-2 #COVID19
-Irritable Bowel Syndrome
-Central Nervous System
#DDDD 💊
Firstly, I would like to draw your attention towards the extensive co operation between 4D and @Merck
Merck are a $200b company
With the 4th Largest drug in the world 💥
KEYTRUDER®️ (based on $7+ billion Revenues in 2019)
pharmaceutical-technology.com/features/top-s…
Firstly, I would like to draw your attention towards the extensive co operation between 4D and @Merck
Merck are a $200b company
With the 4th Largest drug in the world 💥
KEYTRUDER®️ (based on $7+ billion Revenues in 2019)
pharmaceutical-technology.com/features/top-s…
7 Reasons Why @challiance is Giving N-acetylcysteine (#NAC) to #COVID19 + Patients with Early Respiratory Symptoms
NACinCOVID.net
#NACinCOVID
@MLaiB
NACinCOVID.net
#NACinCOVID
@MLaiB
1. #NAC is a powerful antioxidant...
NAC=N-acetyl derivative of amino acid L-cysteine, precursor of the body’s primary intracellular antioxidant glutathione (GSH). (Behold the reducing power of thiol -SH groups!)
NAC=N-acetyl derivative of amino acid L-cysteine, precursor of the body’s primary intracellular antioxidant glutathione (GSH). (Behold the reducing power of thiol -SH groups!)
... antioxidant #NAC scavenges reactive O2 species (ROS) that signal pro-inflammatory molecules that can incite #CytokineStorm
... hope is to prevent body's immune response from overshooting and progressing to cytokine storm and #ARDS
... hope is to prevent body's immune response from overshooting and progressing to cytokine storm and #ARDS
(1/7) Q. Is obesity really a risk factor for #COVID19?
A. It’s not necessarily a risk factor for infection, but a small number of studies suggest individuals with BMI > 30 (defined as "obese") are more likely to be hospitalized than individuals with BMI <30.
A. It’s not necessarily a risk factor for infection, but a small number of studies suggest individuals with BMI > 30 (defined as "obese") are more likely to be hospitalized than individuals with BMI <30.
(2/7) Other studies show that individuals considered obese are more likely to need ventilation or admission to acute and critical care units.
These patterns are especially pronounced among adults YOUNGER THAN 60/65 years of age (depending on the study)
These patterns are especially pronounced among adults YOUNGER THAN 60/65 years of age (depending on the study)
(3/7)
Excess body fat can induce immune dysregulation and chronic inflammation which is linked to the #CytokineStorm responsible for Acute Respiratory Distress Syndrome in respiratory diseases.
Abdominal obesity, especially, can cause compress in the diaphragm and lungs.
Excess body fat can induce immune dysregulation and chronic inflammation which is linked to the #CytokineStorm responsible for Acute Respiratory Distress Syndrome in respiratory diseases.
Abdominal obesity, especially, can cause compress in the diaphragm and lungs.
let's talk about #CytokineStorm in #COVID19.
1st, there is no standard threshold above which something is called #CytokineStorm.
Mechanistically, the simplest form of #CytokineStorm we can understand is when anti-CD19 #CART cells are infused in tumor-bearing recipients.
1st, there is no standard threshold above which something is called #CytokineStorm.
Mechanistically, the simplest form of #CytokineStorm we can understand is when anti-CD19 #CART cells are infused in tumor-bearing recipients.
in this scenario, we have large numbers of antigen-specific T cells (anti-CD19) and large numbers of antigen-bearing cells (CD19+ tumor cells). When too many T cells engage with too many antigens simultaneously in a short period of time we get #CytokineStorm
Why is that? This is because naturally developing an adaptive immune system (T cells) ordinarily doesn't work that way. 1st, for a given antigen we have very few antigen-specific T cells (~ 50 cells/antigen, unlike anti-CD19 CAR-T cells that are in millions).
Starting a series on clinical Pearls I am gathering in #COVID19 patients based on experiences of many experts
Will add as we go along
Feel free to add your own observations/experiences
#covidclinicalpearls /1
Will add as we go along
Feel free to add your own observations/experiences
#covidclinicalpearls /1
Anosmia is likely the most specific #COVID19 related symptom
30% of patients have anosmia as their 1st symptom
#covidclinicalpearls /2
30% of patients have anosmia as their 1st symptom
#covidclinicalpearls /2
Around 90% of patients have fever.
50% maybe afebrile at the time of presentation
Fever tends to be very resistant to routine measures in hospitalized patients
There is no consensus that NSAIDs are to be avoided in #COVID2019 patients
#covidclinicalpearls /3
50% maybe afebrile at the time of presentation
Fever tends to be very resistant to routine measures in hospitalized patients
There is no consensus that NSAIDs are to be avoided in #COVID2019 patients
#covidclinicalpearls /3
"Cytokine Storm". The idiot's buzzword of the week. It makes you sound smarter if you say it often enough. When I first heard of it in 1994 it sounded AMAZING! Then this RCT came out showing it increased mortality. Ouch nejm.org/doi/full/10.10…
Next came rhAPC (drotrecogin). Don't knock out the immune system: we need it to survive. APC has signalling properties to modulate inflammation. NEJM PROWESS was touted a success! nejm.org/doi/full/10.10…
Just as we were celebrating and retrospective analyses showed efficacy correlated with drotrecogin reducing Il-6 levels, bad news came in and the dream turned sour nejm.org/doi/full/10.10…
After a week of self-isolation (with presumed mild COVID 🤒) reading just a few of the astonishing number of #SARSCoV2 & #COVID19 papers/pre-prints in between doses of paracetamol... Some thoughts and questions about what we know so far about COVID19 #immunology. 1/12
The big questions (IMO): does an aberrant immune response contribute to bad clinical outcomes? What is the nature of this immunopathological response? And conversely, what is a protective immune response to #SARSCoV2? 2/12
Inflammatory cytokines eg IL6, TNF correlate with severity/ARDS. IL10, chemokines also up. High admission IL6 predicts bad outcomes. thelancet.com/journals/lance…, academic.oup.com/cid/advance-ar…. What cells drive #CytokineStorm? Does it cause deterioration or is it a bystander phenotype? 3/12
Lessons from past #coronavirus & #influenza #epidemics suggest that #viral #infections can trigger acute coronary syndromes, arrhythmias, exacerbation of heart failure owing to a combination of a significant systemic inflammatory response plus localized vascular inflammation.
#COVID19 may either induce new cardiac pathologies &/or exacerbate underlying cardiovascular diseases. A large proportion of patients have underlying cardiovascular disease &/or cardiac risk factors. Factors associated with mortality include male sex, advanced age, comorbidities.
