Discover and read the best of Twitter Threads about #belatacept
Most recents (2)
Images of Infectious Diseases
6 mo post-tx: H&E (400x) of cervical biopsy of 46F s/p living unrelated donor kidney tx for adult PCKD.
Belatacept. MMF. Prednisone.
Acute cellular + antibody-mediated rejection.
CMV D+/R-. valganciclovir prophylaxis.
DDx / Rx? #MayoIDQ next
6 mo post-tx: H&E (400x) of cervical biopsy of 46F s/p living unrelated donor kidney tx for adult PCKD.
Belatacept. MMF. Prednisone.
Acute cellular + antibody-mediated rejection.
CMV D+/R-. valganciclovir prophylaxis.
DDx / Rx? #MayoIDQ next
2/
Case diagnosis: breakthrough CMV disease with cervicitis
H&E intranuclear / intracytoppasmic inclusions within endothelial cells in ectocervical stroma.
Immunohistochemistry stain for CMV shows infected endothelial cells with CMV inclusions.
doi.org/10.1111/tid.13…
Case diagnosis: breakthrough CMV disease with cervicitis
H&E intranuclear / intracytoppasmic inclusions within endothelial cells in ectocervical stroma.
Immunohistochemistry stain for CMV shows infected endothelial cells with CMV inclusions.
doi.org/10.1111/tid.13…
3/
#MayoIDQ Breakthrough CMV disease, while receiving valGCV prophylaxis, is concerning for over-immunosuppression, under-dosing of val GCV, and/or drug-resistant virus.
If gene sequencing shows the most common CMV gene mutation, what drug would be recommended Rx?
#MayoIDQ Breakthrough CMV disease, while receiving valGCV prophylaxis, is concerning for over-immunosuppression, under-dosing of val GCV, and/or drug-resistant virus.
If gene sequencing shows the most common CMV gene mutation, what drug would be recommended Rx?
1/
Another #immunosuppression #tweetorial...spotlight today on #belatacept today
How do you say it? @Babybel @MedTweetorials
Another #immunosuppression #tweetorial...spotlight today on #belatacept today
How do you say it? @Babybel @MedTweetorials
2/
Belatacept is the FUSION protein that has been the @NKOTB in #kidneytransplant - having been approved for use in 2011.
What's fused?
1. Human IgG1 Fc fragment
2. Extracellular domain of cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4)
pubmed.ncbi.nlm.nih.gov/25416857/
Belatacept is the FUSION protein that has been the @NKOTB in #kidneytransplant - having been approved for use in 2011.
What's fused?
1. Human IgG1 Fc fragment
2. Extracellular domain of cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4)
pubmed.ncbi.nlm.nih.gov/25416857/
3/
The goal of this fusion protein? Disrupt Signal 2⃣ of the 3⃣-Signal T-cell activation pathway
Signal 2 = Binding of CD28 (on T-cell) to B7-1/B7-2 (on APC)
This important step is called co-stimulation and is necessary for T-cell activation
nejm.org/doi/full/10.10…
The goal of this fusion protein? Disrupt Signal 2⃣ of the 3⃣-Signal T-cell activation pathway
Signal 2 = Binding of CD28 (on T-cell) to B7-1/B7-2 (on APC)
This important step is called co-stimulation and is necessary for T-cell activation
nejm.org/doi/full/10.10…
