Discover and read the best of Twitter Threads about #kidneytransplant
Most recents (12)
My hero mom successfully donated one of her kidneys to my dad @NM_Transplant last week! As a family with Polycystic Kidney Disease @PKDFoundation we have prepared for this for decades since my grandpa was diagnosed and transplanted in 2001. 🧵 
As a 7-year old, I remember feeling so confused that someone else’s kidney was functioning in my grandpa. Fast forward to pharmacy school @UIPharmacy when I learned of the immense impact a transplant pharmacist could have on the transplant process.
Close monitoring of immunosuppression, patient and family counseling, and participation in transplant selection committees - all pushed me to pursue a career in clinical pharmacy. I wanted to help families like mine through this process.
1) Welcome to our new #accredited #tweetorial which is Part 2 of a 2-part "highlights" program on new #SGLT2i & #DKD data presented at @ERAkidney #ERA22. #Physicians #nurses #pharmacists #PAs and #NPs can all earn 0.5h CE/#CME by following this 🧵!
2a) @ERAkidney #ERA22 is a primary international scientific symposium for interaction and exchange among basic scientists and clinicians working in #Nephrology. Our expert author is Dr. Clara García Carro (@ClaraGCarro) from San Carlos Clinical Hospital (Madrid, Spain).
2b) Be sure to check out the first half of this #ERA22 recap from my colleague @shbermejo, and get MORE 🆓CE/#CME at ckd-ce.com/dkd12_ERA22a/. Join me in following @ckd_ce for the BEST in #cardiorenal education delivered entirely by #tweetorial!
Good morning followers, new and not-new! After the flux of newcomers this weekend, I thought I’d introduce a little bit more about me + my journey so far to becoming a scientific/data illustrator. Read within! ⬇️🧵🪞🔬👨🏻🎓 #bio #aboutme #art #artist #scientificillustration #sciart
My name's Mark and I am super passionate about telling science stories with the power of visual media🎨 I love illustration, I learn best with visuals, and I am constantly looking for (er, doodling?) ways to make pictures say MORE than just "a thousand words” 😉
I've always been drawn to art as a kid. Ever since I could hold a pencil, I've been creatively engaged. Growing up I was discouraged from pursuing art (who wasn't?) and so I gradually developed an interest in science. Natural History is my favourite subject. 🌐🪱🐒🦀🦩🍄🪸🪐✨
1/17 Taking forward the theme of #WorldKidneyDay let’s discuss what it means for “#WOMEN to live well with #kidney disease” 💃
🧵ahead is for anyone who cares about 💃!
@womeninnephro #womenempowerment #WomensDay #WomensHistoryMonth
Q-Do kidney diseases affect women differently?
🧵ahead is for anyone who cares about 💃!
@womeninnephro #womenempowerment #WomensDay #WomensHistoryMonth
Q-Do kidney diseases affect women differently?
2/17
Women have
⬆️Autoimmune diseases (SLE, RA, Systemic Scleroderma)
In #Women of Color that's 2- 3X commoner, early-onset with⬆️ complications
⬆️UTI due to short urethra
In #Pregnancy ⬆️risk of pyelonephritis and sepsis
karger.com/Article/FullTe…
Women have
⬆️Autoimmune diseases (SLE, RA, Systemic Scleroderma)
In #Women of Color that's 2- 3X commoner, early-onset with⬆️ complications
⬆️UTI due to short urethra
In #Pregnancy ⬆️risk of pyelonephritis and sepsis
karger.com/Article/FullTe…
3/17 Pregnancy poses a high risk of #kidney injury due to various etiologies (see pic) which can progress to CKD in the future.
#Preeclampsia is a definite risk factor for #CKD and #ESKD in mother and also for #cardiovascular disease
pubmed.ncbi.nlm.nih.gov/26342729/
#Preeclampsia is a definite risk factor for #CKD and #ESKD in mother and also for #cardiovascular disease
pubmed.ncbi.nlm.nih.gov/26342729/
Continuing our #KidneyWk virtual e-poster tour! Check out this thread for some interesting research on #exercise, #PhysicalActivity, & #PhysicalFunction in CKD and ESKD!
A comparison of #frailty measures among individuals referred for #KidneyTransplant in Canada (PO1704). #KidneyWk @FilteredDoc @tennankore @CNTN_RCEN
A pilot RCT to embed technology-enabled group-based #Exercise programming in the clinic: The Exercise Is Medicine in Chronic Kidney Disease Trial (PO2057). #KidneyWk @felipelobelo @ahadbootwala @Shuchi_Anand @JasonCobbMD
One upside of #KidneyWk being virtual, is the ability to view posters on-demand through the ASN website (bit.ly/3maGrDJ)! Check out this thread highlighting a few of the posters on #exercise, #PhysicalActivity, & #PhysicalFunction that were presented today!
A pilot & feasibility RCT targeting #SedentaryBehavior in CKD: Results from the Sit Less, Interact and Move More (SLIMM) Study (PO0586). #KidneyWk @UofUNephrology
The association of self-reported & objective measures of #PhysicalActivity with leg muscle mitochondrial oxidative capacity in CKD (PO2062). #KidneyWk
@broshan @JLGamboa_Velez
@broshan @JLGamboa_Velez
1/
Another #immunosuppression #tweetorial...spotlight today on #belatacept today
How do you say it? @Babybel @MedTweetorials
Another #immunosuppression #tweetorial...spotlight today on #belatacept today
How do you say it? @Babybel @MedTweetorials
2/
Belatacept is the FUSION protein that has been the @NKOTB in #kidneytransplant - having been approved for use in 2011.
What's fused?
1. Human IgG1 Fc fragment
2. Extracellular domain of cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4)
pubmed.ncbi.nlm.nih.gov/25416857/
Belatacept is the FUSION protein that has been the @NKOTB in #kidneytransplant - having been approved for use in 2011.
What's fused?
1. Human IgG1 Fc fragment
2. Extracellular domain of cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4)
pubmed.ncbi.nlm.nih.gov/25416857/
3/
The goal of this fusion protein? Disrupt Signal 2⃣ of the 3⃣-Signal T-cell activation pathway
Signal 2 = Binding of CD28 (on T-cell) to B7-1/B7-2 (on APC)
This important step is called co-stimulation and is necessary for T-cell activation
nejm.org/doi/full/10.10…
The goal of this fusion protein? Disrupt Signal 2⃣ of the 3⃣-Signal T-cell activation pathway
Signal 2 = Binding of CD28 (on T-cell) to B7-1/B7-2 (on APC)
This important step is called co-stimulation and is necessary for T-cell activation
nejm.org/doi/full/10.10…
1/ A continuation #tweetorial from my last one introducing human leukocyte antigen (#HLA) , the cell surface antigen...
Below, let's briefly review basics of #Luminex testing & "cross-matching."
What/who is Luminex?
Below, let's briefly review basics of #Luminex testing & "cross-matching."
What/who is Luminex?
2/ In this #tweetorial, we'll answer 3Qs that help us assess a #kidneytransplant recipient's immunological risk:
1. Does this recipient have #DSA* (against HLA-antigens) ?
2. Can the antibodies bind?
3. Can the antibodies activate complement?
*DSA: donor specific antibodies
1. Does this recipient have #DSA* (against HLA-antigens) ?
2. Can the antibodies bind?
3. Can the antibodies activate complement?
*DSA: donor specific antibodies
1/ A short #tweetorial introducing human leukocyte antigen (HLA) and typing...an important and often confusing topic in #transplantation #kidneytransplant
#FOAMed @MedTweetorials
What is an "HLA"?
#FOAMed @MedTweetorials
What is an "HLA"?
2/
HLAs = cell surface proteins encoded by highly polymorphic major histocompatibility complex (MHC) genes on Ch 6 🧬
In #transplantation, HLA proteins are #polymorphic antigens ➡️ alloreactive trigger for the immune response ➡️ can ultimately lead to organ #rejection ☠️
HLAs = cell surface proteins encoded by highly polymorphic major histocompatibility complex (MHC) genes on Ch 6 🧬
In #transplantation, HLA proteins are #polymorphic antigens ➡️ alloreactive trigger for the immune response ➡️ can ultimately lead to organ #rejection ☠️
3/ The 2 primary classes of MHC molecules are 1⃣ and 2⃣.
Class 1⃣ MHC are found on the cell surface of ALL nucleated cells + platelets. Their role is to present intracelleular peptide fragments to CD8 #Tcells
Class 1⃣ MHC are found on the cell surface of ALL nucleated cells + platelets. Their role is to present intracelleular peptide fragments to CD8 #Tcells
1/ Continuing the #immunosuppression #tweetorial series...@MedTweetorials
Today's player: #mTORi, mammalian/mechanistic target of rapamcyin inhibitors
Rapamcyin was @US_FDA approved for #kidneytransplant in 2003.
It was isolated from a soil sample from which island in 1975?
Today's player: #mTORi, mammalian/mechanistic target of rapamcyin inhibitors
Rapamcyin was @US_FDA approved for #kidneytransplant in 2003.
It was isolated from a soil sample from which island in 1975?
2/ Meet mTOR, a phosphatidylinositol 3-kinase (PI3)-related kinase (adds a phos). mTOR adds a phosphoryl group to serine/threonine residues.
It is a key component of the complexes mTORC1 and mTORC 2 - which regulate processes including cell growth, proliferation, and survival.
It is a key component of the complexes mTORC1 and mTORC 2 - which regulate processes including cell growth, proliferation, and survival.
3/ mTOR inhibition blocks "Signal 3" of #TCell activation - reducing cytokine dependent cell proliferation and activation.
Take a look at all 3 signals below 👇🏽
nejm.org/doi/full/10.10…
Take a look at all 3 signals below 👇🏽
nejm.org/doi/full/10.10…
1/
A brief #tweetorial on the calcineurin inhibitors #CNI and their toxicities. Let's start with a quick poll.
Which of the following describes the main mechanism of action of #CNI?
A brief #tweetorial on the calcineurin inhibitors #CNI and their toxicities. Let's start with a quick poll.
Which of the following describes the main mechanism of action of #CNI?
2/
On to the mechanism of #CNI. Calcineurin inhibitors bind to the "immunophiliins" for which they are named. Cyclosporine (CsA) binds cyclophilin and tacrolimius(FK506) binds FK binding protein.
The CNI-immunophilin complex is the superhero which then inhibits calcineurin
On to the mechanism of #CNI. Calcineurin inhibitors bind to the "immunophiliins" for which they are named. Cyclosporine (CsA) binds cyclophilin and tacrolimius(FK506) binds FK binding protein.
The CNI-immunophilin complex is the superhero which then inhibits calcineurin
3/
Meet calcineurin, whose superpower is a calcium-dependent PHOSPHATASE: enzyme that uses H2O to cleave phosphoric acid into a phosphate ion and an alcohol (read: removes phos)
Normally, calcineurin dephosphorylates NFAT - allowing it to freely swim into the nucleus.
Meet calcineurin, whose superpower is a calcium-dependent PHOSPHATASE: enzyme that uses H2O to cleave phosphoric acid into a phosphate ion and an alcohol (read: removes phos)
Normally, calcineurin dephosphorylates NFAT - allowing it to freely swim into the nucleus.
Today is #WorldKidneyDay, so here is a thread about living on #dialysis & #OrganDonation. My name is Belinda Otas. I’m #African. I’m #Nigerian. I'm #Benin. I’m #British & I’m #Black. Beyond the nationalities or passports with my name, I also believe in our shared humanity.
I was 16, when I was diagnosed with End Stage Renal Failure (ESRF.) I had no idea what was happening to me because at the time, it made no sense. However, I remember the pain of that period like noonday. I lived on dialysis until i was 22. #dialysis #OrganDonation #renalhealth
It took over my teenage years. I don’t remember having much of a life as a teenager because dialysis was 3x a week & every session was 4hrs. Add the time it takes to recover from being exhausted by the process, my day was pretty much over. #dialysis #OrganDonation #renalhealth
