Discover and read the best of Twitter Threads about #anticoagulants

Most recents (7)

Spot the difference (1)
20 days after starting anticoagulants, 10 days after my 1st apheresis treatment.
Remarkable findings: less brainfog, less dizzy, less joint pain, less muscle burning, less headaches.
#ME #MEcfs #LongCovid #microclots #HELPApheresis #anticoagulants
1/4
Spot the difference (2)
Huge improvement in available energy, cleaning my deck was impossible since winter 2020. The ‘short of breath’ symptom is less but still present, had to pause frequently. No crash, no PEM. I feel alive again.
2/4
Thank you for your help, research and sharing information:
@BeateJaegerMD @doctorasadkhan @dbkell @resiapretorius @MarekSJF @loscharlos @tjalcovrv @smithsj and all my dear #pwME friends.

Great video on H.E.L.P. Apheresis:

3/4
Read 4 tweets
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications | Biochemical Journal | Portland Press. portlandpress.com/biochemj/artic…
“These microclots are more-or-less easily measured in PPP with the stain thioflavin T and a simple fluorescence microscope. Although the symptoms of Long COVID are multifarious, we here argue that . .
the ability of these fibrin amyloid microclots (fibrinaloids) to block up capillaries, and thus to limit the passage of red blood cells and hence O2 exchange, can actually underpin the majority of these symptoms.” #anticoagulants #LongCovid
Read 5 tweets
New @polybioRF podcast! I interviewed Dr. Resia Pretorius: Department Head/Research Professor at Stellenbosch University in South Africa. Listen on an App like Spotify () or watch on Youtube ()
2/ In the interview Resia talks about how her research team has identified microclots resistant to fibrinolysis + hyperactivated platelets in the blood of #LongCovid patients. We also discuss how we are planning to extend the research to #ME/CFS
3/ When it comes to the LongCovid microclots, Resia describes her earlier research showing that platelets (blood cells that contribute to #clotting) have receptors that recognize a wide range of viral, bacterial, and fungal proteins or products
Read 6 tweets
‘Overall, #antiplatelet monotherapy is ineffective for #stroke prevention [for #AtrialFibrillation] & potentially harmful (especially #elderly), whereas #DAPT associated with bleeding risk similar to OAC. Hence, antiplatelets should not be used for #stroke prevention in #AF
2020 ESC Guidelines for the diagnosis and management of #AtrialFibrillation #ESCCongress : academic.oup.com/eurheartj/adva…
‘Between 2009 & 2018, in #England, the use of #OAC for #stroke prophylaxis in #AtrialFibrillation increased, with #DOAC accounting for over half of OAC uptake in 2018.’
Read 7 tweets
This population-based, multicentre, 10-year study of the use of oral #anticoagulants for #stroke prophylaxis for ~0.5M patients with #AFib found that their prescription for patients with #AF at high risk of stroke increased by nearly 60%.
Between 2009 & 2018, 3352 individual General Practices provided a total of 5968 uploads into the GRASP-AF database. From the first upload per General Practice, there were an estimated 450 518 patients with #AFib from a total of 24 644 210 people.
Over the study period the prevalence of AF was 1.8% [95% CI 1.7–1.9%], which increased from 1.6% (1.5–1.7%) in 2009 to 2.4% (2.3–2.5%) in 2018 (P-trend < 0.001). Image
Read 17 tweets
Study warns against combined use of oral #anticoagulants , #antiplatelet therapy for #AFib 1️⃣

#GARFIELD-AF registry

escardio.org/The-ESC/Press-…
2️⃣ Currently, do you stop #aspirin w #NOAC #DOAC for #AFIB in pts w previous history of stent (>1yr prior) for non-ACS CAD ? (Yes- I know it should be a less and less common scenario)
3️⃣ Currently, do you stop #aspirin w #NOAC #DOAC for #AFIB in pts w previous history of CAD ( #STEMI / #NSTE-ACS >1year prior) ?
Read 3 tweets

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