Discover and read the best of Twitter Threads about #clotting
Most recents (4)
@kimisgubbed @VirusesImmunity @KaminskiMed @Be_Kinderr @jenbrea @ahandvanish Hey! Well hypoxic tissue cld lead to lower O2 extraction, & infected tissue is often hypoxic. Most intracellular pathogens hijack metabolism of cells they infect & “push” host mitochondrial metabolism to anerobic glycolysis (O2 not being used for OXPHOS): ij.hapres.com/htmls/IJ_1341_…
@kimisgubbed @VirusesImmunity @KaminskiMed @Be_Kinderr @jenbrea @ahandvanish 2/ In fact many intracellular #pathogens either directly or indirectly enhance hypoxia inducible factor (HIF-1) stability. HIF-1 is a key glycolytic regulator/transcription factor whose stability reduces reliance on OXPHOS by initiating glycolytic #metabolism
@kimisgubbed @VirusesImmunity @KaminskiMed @Be_Kinderr @jenbrea @ahandvanish 3/ With that in mind @VirusesImmunity, it was interesting that in your brain organoid model, you showed SARS-CoV-2 capable of infecting neurons, where it induced a locally hypoxic environment as measured by staining for HIF-1 alpha: pubmed.ncbi.nlm.nih.gov/33433624/
New @polybioRF podcast! I interviewed Dr. Resia Pretorius: Department Head/Research Professor at Stellenbosch University in South Africa. Listen on an App like Spotify () or watch on Youtube ()
2/ In the interview Resia talks about how her research team has identified microclots resistant to fibrinolysis + hyperactivated platelets in the blood of #LongCovid patients. We also discuss how we are planning to extend the research to #ME/CFS 
3/ When it comes to the LongCovid microclots, Resia describes her earlier research showing that platelets (blood cells that contribute to #clotting) have receptors that recognize a wide range of viral, bacterial, and fungal proteins or products
This is a really important preprint. @dbkell, @resiapretorius used a range of techniques to image clotting in the blood of #COVID-19 patients vs. controls...and found MAJOR differences in COVID-19 blood clotting patterns: medrxiv.org/content/10.110…
Hmm. I'm aware that authors don't always set their own headline, but this one's actually misleading.
If anything, #COVID19 will likely become like a '#FifthFlu', i.e. a seasonal killer - not MERS or SARS, bur *far* less benign than the common cold...
unherd.com/2020/07/why-co…
If anything, #COVID19 will likely become like a '#FifthFlu', i.e. a seasonal killer - not MERS or SARS, bur *far* less benign than the common cold...
unherd.com/2020/07/why-co…
As @TomChivers points out, with so many publications and so much amplification, it can be difficult to work out what's going on.
There's encouraging news on the #vaccine front, with provisos: of which KCL's #antibody study is one:
There's encouraging news on the #vaccine front, with provisos: of which KCL's #antibody study is one:
