Discover and read the best of Twitter Threads about #Metaanalysis
Most recents (24)
1/ Meta-analysis is a powerful statistical technique for synthesizing data from multiple studies. In R, there are several packages available for conducting meta-analyses. Let's take a look at some of them! #RStats #MetaAnalysis #DataScience 
2/ There are several R packages available to conduct meta-analysis, but some of the most popular include metafor, meta, and netmeta. Each package has its own strengths and weaknesses, so it's important to choose the right one for your specific analysis. #rstats
3/ metafor is a powerful package that can handle complex meta-analyses with multiple predictors and moderators. It also has robust methods for dealing with publication bias. However, it can be a bit tricky to use for beginners. #rstats
Tuxedo Protocols: github.com/broadinstitute…
This repository contains a collection of protocols and tools for analyzing RNAseq data, including alignment, quantification, and differential expression analysis. (1/10)
This repository contains a collection of protocols and tools for analyzing RNAseq data, including alignment, quantification, and differential expression analysis. (1/10)
RNASeq Workflow: github.com/gringer/RNASeq…
This repository contains a workflow for analyzing RNAseq data using the R programming language, including quality control, alignment, and differential expression analysis. (2/10)
This repository contains a workflow for analyzing RNAseq data using the R programming language, including quality control, alignment, and differential expression analysis. (2/10)
The programme for #ESMARConf2023 is taking shape!
We'll have an incredibly exciting and engaging week of talks, panel discussions, workshops, tutorials and networking opportunities!
Here's a thread with a few details...
#EvidenceSynthesis #MetaAnalysis #RStats
1/8
We'll have an incredibly exciting and engaging week of talks, panel discussions, workshops, tutorials and networking opportunities!
Here's a thread with a few details...
#EvidenceSynthesis #MetaAnalysis #RStats
1/8
We're hoping to have 6 hackathons around #ESMARConf2023 - these are slow-burn group projects run over the year to produce or develop FREE tools to support evidence synthesis!
FREE TOOLS, PEOPLE!
2/8
FREE TOOLS, PEOPLE!
2/8
We hope to have 10 x 60-minute panel discussions, covering things like: using text analysis to support search methods; rapid reviews and R; stakeholder engagement and evidence synthesis, plus tonnes more!
3/8
3/8
Thread re: evidence appraisal/paucity of #PedsICU data based on recent @ESPNIC_Society guidelines on IV maintenance fluids
link.springer.com/content/pdf/10… @yourICM
Started by discussions in our monthly #PICUJournalWatch sessions @Bham_Childrens #PedsICU based on @PICJournalWatch
1/
link.springer.com/content/pdf/10… @yourICM
Started by discussions in our monthly #PICUJournalWatch sessions @Bham_Childrens #PedsICU based on @PICJournalWatch
1/
PICO3: The paper states [& I don't disagree]:
In "critically ill children", balanced solutions should be favoured when prescribing *intravenous maintenance* fluid therapy to slightly reduce length of stay:
B Strong consensus
& "in acutely ill children": A Strong consensus 2/
In "critically ill children", balanced solutions should be favoured when prescribing *intravenous maintenance* fluid therapy to slightly reduce length of stay:
B Strong consensus
& "in acutely ill children": A Strong consensus 2/
They add "balanced IV-MFT solutions, the length
of acute care or PICU stay were slightly but significantly decreased in children receiving balanced solutions in a meta-analysis of 5 studies, including 283 patients. mean difference: −0.20 days; 95% CI [−0.33; −0.08], p=0.001 3/
of acute care or PICU stay were slightly but significantly decreased in children receiving balanced solutions in a meta-analysis of 5 studies, including 283 patients. mean difference: −0.20 days; 95% CI [−0.33; −0.08], p=0.001 3/
What causes back pain?🤔
Specifically: how much do nervous system, spine tissue and psychosocial contribute to #backpain?
#systematicreview with multivariate #metaanalysis in European J Pain @EFIC_org
doi.org/10.1002/ejp.18…
Led by @ScottTags 🙏collaborators
Thread
👇
Specifically: how much do nervous system, spine tissue and psychosocial contribute to #backpain?
#systematicreview with multivariate #metaanalysis in European J Pain @EFIC_org
doi.org/10.1002/ejp.18…
Led by @ScottTags 🙏collaborators
Thread
👇
Low #backpain is leading cause of disability worldwide… 90-95% of cases are considered 'non-specific'
Many factors can contribute
Image 👇from doi.org/10.2147/jpr.s1… @chadcookpt
But which ones and how much?
Many factors can contribute
Image 👇from doi.org/10.2147/jpr.s1… @chadcookpt
But which ones and how much?
Individual meta-analyses + factors associated with back pain
➡️ pain processing doi.org/10.1097/j.pain…
➡️ disc degeneration doi.org/10.3174/ajnr.A…
➡️ muscle atrophy doi.org/10.2522/ptj.20…
➡️ depression / distress doi.org/10.1093/fampra…
But is one more important than other?
➡️ pain processing doi.org/10.1097/j.pain…
➡️ disc degeneration doi.org/10.3174/ajnr.A…
➡️ muscle atrophy doi.org/10.2522/ptj.20…
➡️ depression / distress doi.org/10.1093/fampra…
But is one more important than other?
"As the wave of conferences sweeping across the globe continues, artistic expressions emerging from these gatherings are conveying an essential longing of the human soul: the need to seek harmony and to selflessly serve society."--Bahai World News Service greeneracresvaluenetwork.wordpress.com/2022/04/28/dai…
Crowd and Proud: The History of the Flash Mob - ELEPHANT
elephant.art/crowd-and-prou…
#FlashMobs, #culture, #history
elephant.art/crowd-and-prou…
#FlashMobs, #culture, #history
Investigating the upper bound of high-frequency electromagnetic waves on unshielded twisted copper pairs | Nature Communications
nature.com/articles/s4146…
#HighFrequencyElectroMagneticWaves, #CopperPairs, #ScientificInvestigation
nature.com/articles/s4146…
#HighFrequencyElectroMagneticWaves, #CopperPairs, #ScientificInvestigation
How #sleep loss may make physical #exercise more challenging for the #heart:
We find that sleep loss ⬆️ the exercise 🚴♀️-induced ⬆️ in blood levels of a #cardiac stress biomarker vs. after normal sleep
But note, exercise is essential for your health
🧵->
sciencedirect.com/science/articl…
We find that sleep loss ⬆️ the exercise 🚴♀️-induced ⬆️ in blood levels of a #cardiac stress biomarker vs. after normal sleep
But note, exercise is essential for your health
🧵->
sciencedirect.com/science/articl…
2/ Extensive epidemiological data has found that sleep impacts the risk of cardiovascular disease (CVD).
E.g. @uk_biobank (n~408k):
Vs. 7 h, sleep duration of ≤5 h & ≥9 h were associated with higher risk of CVD mortality & incidence (~+8-30%).
sciencedirect.com/science/articl…
E.g. @uk_biobank (n~408k):
Vs. 7 h, sleep duration of ≤5 h & ≥9 h were associated with higher risk of CVD mortality & incidence (~+8-30%).
sciencedirect.com/science/articl…
3/ And elegant human experimental studies have shown that curtailed #sleep can adversely impact🫀physiology.
For instance, shortened sleep can ⬆️ #bloodpressure in humans, seen both after overnight wakefulness academic.oup.com/sleep/article/… & shortened sleep ahajournals.org/doi/abs/10.116….
For instance, shortened sleep can ⬆️ #bloodpressure in humans, seen both after overnight wakefulness academic.oup.com/sleep/article/… & shortened sleep ahajournals.org/doi/abs/10.116….
It was so great to give a (virtual) talk to the Hellenic Society of Cardiology on #covid and #whycmr- hopefully next year in person with no more need 4 Covid talks! Short 🧵 on CMR use #epeeps #cardioed #echofirst #tavr #metaanalysis …/2
#covid is bad for many organs- including the heart. The role of ACE2 receptors to facilitate entry to the cells is well known! But for the heart Covid does lead to #infarction #arrhythmias #heartfailure #myopericarditis What can you do to avoid this? GET A #VACCINE
🧵THREAD
In honour of the #Hernia2021 congress hosted by the BJS strategic partner @eurohernias, here is a thread of recent hernia-related BJS papers.
In honour of the #Hernia2021 congress hosted by the BJS strategic partner @eurohernias, here is a thread of recent hernia-related BJS papers.
European Hernia Society guidelines on management of rectus diastasis #rectusdiastasis #Hernia2021 #Hernia
academic.oup.com/bjs/advance-ar…
academic.oup.com/bjs/advance-ar…
Reporting guideline for interventional trials of primary and incisional ventral hernia repair #OpenAccess #Hernia2021 #Hernia #VentralHernia
academic.oup.com/bjs/article/10…
academic.oup.com/bjs/article/10…
Daily Bookmarks to GAVNet 08/17/2021 greeneracresvaluenetwork.wordpress.com/2021/08/17/dai…
A New Antibody-Dependent Enhancement Hypothesis
blogs.sciencemag.org/pipeline/archi…
#antibodies #SARSCoV2 #variants #ResearchResults #commentary
blogs.sciencemag.org/pipeline/archi…
#antibodies #SARSCoV2 #variants #ResearchResults #commentary
The U.S. Government Lied For Two Decades About Afghanistan
greenwald.substack.com/p/the-us-gover…
#afghanistan #misinformation #GovernmentAgencies #MilitaryOccupation #consequences
greenwald.substack.com/p/the-us-gover…
#afghanistan #misinformation #GovernmentAgencies #MilitaryOccupation #consequences
Our #systematicreview and #metaanalysis on the association of #sepsis with long-term #CVD is out now in @yourICM ! Surviving sepsis was associated with ⬆️#cvMI, #heartfailure, and #stroke over 5+ years. Take-home points below. tinyurl.com/p5n634jy
1. Many studies have examined the risk of #CVD after #sepsis, but variable population and outcome selection has complicated generalizability. We estimated the risk of #cvMI, #heartfailure, #stroke, and composite #CVD after sepsis relative to hospital and population controls.
2. 12,649 citations identified, 27 (25 cohort, 2 case-crossover) studies included. Median of 4,289 (IQR 502–68,125) sepsis survivors and 18,399 (IQR 4,028–83,506) controls per study. We assessed cumulative incidence and relative risk of #CVD from 30 days to longest follow-up.
Bashing #metaanalysis is as fashionable as ever, as always with hands up in the air. In response to a thread moaning the lack of added value of meta-analyses over individual studies, I realized I know of *many* meta-analyses that literally overturned whole fields.
So I want to start my alternative thread, in which instead the of the same old lamets, we list consequential meta-analyses in #Mentalhealth, which definitely provided more information than each and any single individual study.
These don't have to be methodologically flawless, because no study is. They do have to have a decent quality (which is much less of an elusive construct than oft presented). I will start with a few and update when I have time. Feel free to add to the collection. Order random.
1/- AUSTRALIA ARE THEY LYING?
These video scenes of #brutal #LawEnforcement are from around the world and Australia figures prominently.
It is #dehumanising and mentally debilitating to see this and to comprehend the #inhumanity
Is it right to assault citizens like this?
These video scenes of #brutal #LawEnforcement are from around the world and Australia figures prominently.
It is #dehumanising and mentally debilitating to see this and to comprehend the #inhumanity
Is it right to assault citizens like this?
2/- AUSTRALIA ARE THEY LYING
The #G7summit was a cosy affair. Social distancing for the cameras and free-for-all off-it. #Scomo was in the midst of this #Cornwall retreat to plan the next phase of #Lockstep.
Do any of them appear concerned about the “pannddemmic” ?
The #G7summit was a cosy affair. Social distancing for the cameras and free-for-all off-it. #Scomo was in the midst of this #Cornwall retreat to plan the next phase of #Lockstep.
Do any of them appear concerned about the “pannddemmic” ?
3/- AUSTRALIA ARE THEY LYING?
#Scomo returns from his #G7Summit2021 all buoyed in #Lockstep and then NSW goes into #Lockdown followed by restrictions in other states.
Do you see fingerprints on this?
Is #GladysCluster trying too hard to convince?
See where we are on cases curve??
#Scomo returns from his #G7Summit2021 all buoyed in #Lockstep and then NSW goes into #Lockdown followed by restrictions in other states.
Do you see fingerprints on this?
Is #GladysCluster trying too hard to convince?
See where we are on cases curve??
Paper alert: @heimbergecon +I investigate: Do corporate tax cuts boost economic growth? There is a growing empirical literature. As often, studies come to ambiguous conclusions: corporate tax cuts increase,reduce, or do not signif. affect growth. Thread: boeckler.de/de/faust-detai…
This is a classic partisan fiscal policy debate. One camp claims that tax cuts improve profit margins which will spur investment and thus growth+jobs. The other doubts that higher profits will lead to more investment and claims that the tax revenues could be used more effectively
Former Pres. #Trump promoted the #TCJA, which entailed a large corporate tax cut, insisting on huge growth effects. The #Biden admin. now argues for reversal: funds should better be used for public investment instead. @WhiteHouseCEA
Hurray! Together with great coauthors @DomiEhrenberger, Tomas + Zuzana we finally got it published: Our #metaanalysis on the elasticity of substitution b/w capital and labor, a.k.a. the “Death to the Cobb-Douglas production function” made it to the @RevEconDyn. Thread:
First of all, here’s a 50days free access share link authors.elsevier.com/a/1d7Oo3uolWav… (which seems to work with Chrome though not with Firefox). Please feel free to share it in your networks.
The elasticity (σ) is a central parameter in macroeconomics. It determines how easy (high σ), difficult (low σ) it is to substitute capital (C) and labor (L) inputs in production. At the extreme ends, σ=0 -> no substitutability (Leontief) -> C/L always enter in fixed proportions.
Is #exercise before or after hip joint replacement better than usual care or minimal treatment?
#Metaanalysis in @JAMANetworkOpen @JAMA_current
dx.doi.org/10.1001/jamane…
Led by Tobias, Jochen and Max from @PhysioMeScience
🙏for #collaboration!
Thread
👇👇👇👇
#Metaanalysis in @JAMANetworkOpen @JAMA_current
dx.doi.org/10.1001/jamane…
Led by Tobias, Jochen and Max from @PhysioMeScience
🙏for #collaboration!
Thread
👇👇👇👇
#osteoarthritis is one of the leading causes of #pain, #disability and healthcare resource usage worldwide.
Total hip replacements (THA below) done per year are expected to grow to ~600k per year by 2030
doi.org/10.2106/jbjs.1…
Total hip replacements (THA below) done per year are expected to grow to ~600k per year by 2030
doi.org/10.2106/jbjs.1…
Some guidelines (both from 2020) recommend exercises with hip replacement
@NICEComms nice.org.uk/guidance/ng157
-pre-op advice only
-post-op inpatient ex ✅, outpatient self-directed exercise only
Dutch doi.org/10.1002/msc.14…
-pre-op ex ✅for specific patients
-post-op ✅
@NICEComms nice.org.uk/guidance/ng157
-pre-op advice only
-post-op inpatient ex ✅, outpatient self-directed exercise only
Dutch doi.org/10.1002/msc.14…
-pre-op ex ✅for specific patients
-post-op ✅
@psychgeist52 @drjanaway 1/ Sorry for the late reply @DrJanaway and indeed @psychgeist52, where is the outrage, and from psychiatrists, as asked by Dr Malcolm Kendrick years ago? Also 30 years of failed trials.
drmalcolmkendrick.org/2015/10/01/stu….
drmalcolmkendrick.org/2015/10/01/stu….
@psychgeist52 @drjanaway 2/ #Study329 appeared in the Crime Section of the Huffington Post.
*The trials for Prozac/Fluoxetine are indistinguishable from those of Seroxat/ Paroxetine & other trials in showing *no evidence of benefit* & evidence of a great deal of harm to include preventable deaths
*The trials for Prozac/Fluoxetine are indistinguishable from those of Seroxat/ Paroxetine & other trials in showing *no evidence of benefit* & evidence of a great deal of harm to include preventable deaths
@psychgeist52 @drjanaway 3/ I would appeal to you as a human being to
a) read “Children of the Cure”
b) to imagine #Prozac withdrawal in a child (rxisk.org/antidepressant…)
c) Akathisia, a form of Mental Torture, in a child ()
c) #PSSD (pssdcanada.squarespace.com/our-stories/su…).
a) read “Children of the Cure”
b) to imagine #Prozac withdrawal in a child (rxisk.org/antidepressant…)
c) Akathisia, a form of Mental Torture, in a child ()
c) #PSSD (pssdcanada.squarespace.com/our-stories/su…).
🚨n.b. #postprint 🚨
v10 of our #LivingReview is live on @qeios
We have reviewed 345 studies. 52 of sufficient quality for #MetaAnalysis to explore the association of #Smoking and #COVID19 #infection, #hospitalisation, #severity and #mortality.
qeios.com/read/UJR2AW.11
v10 of our #LivingReview is live on @qeios
We have reviewed 345 studies. 52 of sufficient quality for #MetaAnalysis to explore the association of #Smoking and #COVID19 #infection, #hospitalisation, #severity and #mortality.
qeios.com/read/UJR2AW.11
No dramatic changes from v9 posted in November.
Most studies from 🇺🇸, 🇨🇳 & 🇬🇧 but from 39 countries. 65% hospital based, 8% purely community. Median of 461 individuals per study.
Smoking remains poorly recorded, only 29% of studies categorise as current 🚬, former and never 🚭
Most studies from 🇺🇸, 🇨🇳 & 🇬🇧 but from 39 countries. 65% hospital based, 8% purely community. Median of 461 individuals per study.
Smoking remains poorly recorded, only 29% of studies categorise as current 🚬, former and never 🚭
6 studies report on alternative nicotine products.
Large amounts of missing data in many studies on 🚬 status introducing bias.
Huge reliance on #ElectronicHealthRecords and all the limitations that brings. See our recent #PrePrint if interested (doi.org/10.1101/2020.1…)
Large amounts of missing data in many studies on 🚬 status introducing bias.
Huge reliance on #ElectronicHealthRecords and all the limitations that brings. See our recent #PrePrint if interested (doi.org/10.1101/2020.1…)
#Bevacizumab for #ROP Rx & Neurodevelopment thread
Delighted our #metaanalysis out today in @JPerinatology
Results indicate Neurodevelopment harm associated w/ Avastin Rx
@EBNEO @waseemoddin
nature.com/articles/s4137…
rdcu.be/cbRdK #FOAMneo
1/6
Delighted our #metaanalysis out today in @JPerinatology
Results indicate Neurodevelopment harm associated w/ Avastin Rx
@EBNEO @waseemoddin
nature.com/articles/s4137…
rdcu.be/cbRdK #FOAMneo
1/6
The idea started with a dialogue by a colleague ”We don’t do lasers, they are ancient, we do avastin - simple, easy, less recurrence.”
Me: “there are long term risks - right?”
Colleague: Na, it’s ok, we already accepted & moved 🤨
2/6
Me: “there are long term risks - right?”
Colleague: Na, it’s ok, we already accepted & moved 🤨
2/6
I thought it’s good idea to pursue a #Systematicreview as the evidence is sketchy & controversial but what really pushed me to do the review is👇
Avastin can fire the brain for 60 days (#staylong) by suppressing VEGF that is crucial for brain growth
3/6
is.gd/5BE9AN
Avastin can fire the brain for 60 days (#staylong) by suppressing VEGF that is crucial for brain growth
3/6
is.gd/5BE9AN
A recent study in @nature couldn't replicate drastic CO2 effects on coral reef #fish behaviour & empirically found no effect of #oceanacidification go.nature.com/3hK49UR
Our #metaanalysis of the past decade on this topic concurs ecoevorxiv.org/k9dby/
Breakdown thread👇
Our #metaanalysis of the past decade on this topic concurs ecoevorxiv.org/k9dby/
Breakdown thread👇
We demonstrate one of the most striking examples of the #DeclineEffect in #ecology to date, w/ reported effects of OA on fish behaviour all but disappearing over past decade
If you’ve never heard of the #DeclineEffect see: bit.ly/2EbZX2o
If you’ve never heard of the #DeclineEffect see: bit.ly/2EbZX2o
Qualitatively the number of studies reporting “strong” effects of #oceanacidification on fish behaviour have plummeted over time
My tips for conducting a #SystematicReview - a thread.
1. Have a look whether any systematic review or #metaanalysis has been conducted on your topic before. If so, what (gaps) did they uncover? How did they structure their results? How will your review differ?
#phdchat
1. Have a look whether any systematic review or #metaanalysis has been conducted on your topic before. If so, what (gaps) did they uncover? How did they structure their results? How will your review differ?
#phdchat
2. Have a look at the resources available at @PRISMAStatement, including the checklist and flow diagram (prisma-statement.org/PRISMAStatemen…), and use it to guide your processes.
3. Get in touch with the reference #librarian at your institution, or check out the resources available through any #HigherEducation #library website. They'll have valuable insight into search string development and database best practice.
#LibrariesRock
#LibrariesRock
My new & very likely most important paper of 2020 @TheLancetPsych #network #metaanalysis on the efficacy of cognitive bias modification for #anxiety or #depression in clinical or subclinical patients
(1st author @liviu_fodor, w/ @pimcuijpers @Toshi_FRKW )
thelancet.com/journals/lanps…
(1st author @liviu_fodor, w/ @pimcuijpers @Toshi_FRKW )
thelancet.com/journals/lanps…
People who follow this field know I have been one of its first and unrelenting critics, starting with my meta-analysis in 2015 @TheBJPsych (again w/ @pimcuijpers) cambridge.org/core/journals/…, followed by others, including many viewpoints, comments & replies that I will spare you.
I was one of the first researchers to have explicitly state that maybe #CBM just does not work and there are no moderators or boundary conditions that can save it. But time passed, studies went on, the field continued to grow & adapt, and so maybe it was time for a reassessment.
New #publication “The potential of #digitaltools to enhance #mathematics and #science learning in secondary schools: A context-specific #metaanalysis” published #openaccess in Computers & Education | doi.org/10.1016/j.comp…
The comprehensive meta-analysis investigated how the use of #technology can enhance learning in secondary school mathematics and science. 92 studies compared learning outcomes of students using digital tools to those of a control group taught without the use of digital tools.
Key Findings: Overall, digital tool use had a positive effect on student learning outcomes, g = 0.65.
Proud that my first paper as first author just got published in @ejpblog! It’s called “Resting Frontal EEG Asymmetry and Personality Traits: A Meta-analysis”. I worked on it with @w_kaeckenmester and Jan Wacker. I’ll explain what we found below! 1/12
onlinelibrary.wiley.com/doi/abs/10.100…
onlinelibrary.wiley.com/doi/abs/10.100…
Frontal asymmetry describes the difference in brain activity between the left & right frontal cortex and is often measured in the resting state via EEG. It has been used in hundreds of studies as an indicator of motivation, emotion, and psychopathology. 2/12
Research has linked resting frontal asymmetry to personality traits, especially trait approach & withdrawal motivation (BAS & BIS). However, there have been replication issues & it was unclear whether these effects exist & what their magnitude is – so we did a #metaanalysis! 3/12
