Discover and read the best of Twitter Threads about #Genomic
Most recents (23)
1/ Are you a bioinformatics researcher looking for powerful tools to analyse your data? Check out @Bioconductor ! Here are some of my favorite packages for #bioinformatics analyses. 
2/ First up: #DESeq2 by @mikelove. This package provides a method for differential gene expression analysis of RNA-seq data. It's widely used and highly cited in the field, and it's perfect for identifying genes that are differentially expressed between samples.
3/ Next, I recommend #edgeR. Like DESeq2, edgeR is a package for differential gene expression analysis of RNA-seq data. It's particularly useful for smaller sample sizes and can detect differential expression with greater sensitivity.
Are you interested in learning about #bioinformatics and working with #genomic data? Here's a detailed #learning path to get you started:
To build a strong foundation in biology, you'll need to learn about:
The #structure and #function of #cells, including the various #organelles and their roles in the cell. This will help you understand how cells work and how they carry out essential functions such as #metabolism and #energy production.
🧵#Bioinformatics applied to genomics, a THREAD🧵🧵:
#Genomics is the study of the entire #genetic makeup of an #organism, including its #DNA sequence, #gene structure, and regulation of #gene #expression.
#Bioinformatics is the application of computational techniques, such as #machine #learning and data mining, to the analysis of large datasets of biological information, such as #genomic, #proteomic, and #metabolomic data.
Are you interested in getting started in #bioinformatics but not sure where to begin? Here are some tips to help you get started on your journey. A THREAD🧵🧵:
Start by learning a high-level #programming language, such as #Python or #R, and familiarizing yourself with data structures and #algorithms commonly used in #bioinformatics. The #BioPython and #Bioconductor libraries are great resources for this.
🧵#Bioinformatics applications, a THREAD🧵🧵:
One of the key areas of #bioinformatics is the application of #computational techniques to the analysis of large #datasets of biological information, such as #genomic, #proteomic, and #metabolomic data.
#Genomic data provides information about the entire genetic makeup of a #biological system, including the #sequences of all its genes and the #regulation of their e#xpression.
@LisaMWatki That @ukfuturehealth somewhat 'buries the lede' on its intention to construct a giant £212 million 👇 #DNA / #genomic database in its patient literature is somewhat concerning...
find-tender.service.gov.uk/Notice/019818-…
find-tender.service.gov.uk/Notice/019818-…
@LisaMWatki @ukfuturehealth ...not to mention the £62.5 million+ they'll be spending taking people's #bloods, etc.:
find-tender.service.gov.uk/Notice/005068-…
find-tender.service.gov.uk/Notice/005068-…
@LisaMWatki @ukfuturehealth Of course, #OurFutureHealth had to get its money from somewhere.
I'll give you one guess as to where...
ourfuturehealth.org.uk/partners/#htoc…
I'll give you one guess as to where...
ourfuturehealth.org.uk/partners/#htoc…
As business from around the world meet at the @OceanCouncil Sustainable Ocean Summit 🌊 to discuss the #ocean, #climate and #biodiversity, #PLOSBiology is proud to announce our new collection of articles on #OceanSolutions for a sustainable, healthy and inclusive future 🧵1/11
Collection guest editors Nancy Knowlton @SeaCitizens and Emanuele Di Lorenzo @manu_ocean outline their vision for the collection in their Editorial #OceanSolutions 🧵2/11
plos.io/3Tvazu5
plos.io/3Tvazu5
In their Perspective, @jenniferjacquet and Daniel Pauly argue that the current definition of ‘#sustainable fisheries’ should be reimagined to minimize exploitation and prioritize small-scale artisanal and subsistence fishing #OceanSolutions 🧵3/11
plos.io/3MBQfFf
plos.io/3MBQfFf
10 minute reminder: @VanessaPorter will be on stage in the auditorium shortly with her talk: 'Identification of novel #genomic structures and regulation patterns at #HPV integration events in cervical #cancer'. #nanoporeconf
VP: HPV is a necessary driver of cervical cancer. HPV integration is present 70% of cervical cancers. Often disrupts E2 gene & causes structural rearrangements. #nanoporeconf
VP: HPV integration often upregulated neighbouring genes. #nanoporeconf
I see #NHSEx has published the slides from its @HDR_UK “Data Access & Discovery” event, charmingly subtitled “A Forest Through the TREs” - on YouTube, if you want to listen:
__
*I thought the phrase was “cannot see the forest for the TREs”, but hey...
__
*I thought the phrase was “cannot see the forest for the TREs”, but hey...
Let’s take a look:
hdruk.ac.uk/wp-content/upl…
One reason we use the category term #TRE to refer to Trusted Research (or any other use) Environments that meet the #FiveSafes is that everyone wants to call their own TRE something different, so no-one really knows what they mean...
hdruk.ac.uk/wp-content/upl…
One reason we use the category term #TRE to refer to Trusted Research (or any other use) Environments that meet the #FiveSafes is that everyone wants to call their own TRE something different, so no-one really knows what they mean...
Call yours what you like (e.g. for @ONS it's their Secure Research Service) but if it only does four #Safes, or three Safes - and if it isn’t also #consensual and fully #transparent - then it's not a #trustworthy TRE...
Finally, the #GoldacreReview is published! (During Parliamentary Easter holidays, mid-ping-pong on the #HealthAndCareBill...)
It's 221 pages - each PDF page is a double page spread - so this could be a lo-o-o-ong [Thread].
Here goes...
It's 221 pages - each PDF page is a double page spread - so this could be a lo-o-o-ong [Thread].
Here goes...
First point to note, in the Terms of Reference (p5), is that this is about "access to #NHSdata by #researchers, #commissioners, and #innovators" - i.e. #Planning and #CommercialReUse - so it is directly relevant to the operation of millions of people's #NationalDataOptOuts...
"185 wide-ranging recommendations for us to explore", says @sajidjavid (p6). Gulp! Time for some coffee...
"systems that ensure #underrepresented groups are well represented" may (partly) refer to this "landmark review", which got off to a slow start:
gov.uk/government/new…
"systems that ensure #underrepresented groups are well represented" may (partly) refer to this "landmark review", which got off to a slow start:
gov.uk/government/new…
And in this single statement 👇 @MattHancock demonstrates not only his profound ignorance, but his underlying thinking - that information about you is a #TradableAsset.
Who "owns" the fact of your relationship with your sister? You? Her? Or your date of birth? Your current age?
Who "owns" the fact of your relationship with your sister? You? Her? Or your date of birth? Your current age?
Let's not even get started on things like #genomic data (i.e. data derived from your #DNA) which says things not only about you, but your relatives. Who "owns" that?
The reason the #powerful want people to think they "own" their #PersonalData - rather than it being protected...
The reason the #powerful want people to think they "own" their #PersonalData - rather than it being protected...
Will polygenic risk scores (PRSs) for #cancer ever be #clinically useful?
Our (@clare__turnbull @HoulstonLab_ICR @ICR_London) commentary in @Nature_NPJ is out: nature.com/articles/s4169…
A thread:
1/n
Our (@clare__turnbull @HoulstonLab_ICR @ICR_London) commentary in @Nature_NPJ is out: nature.com/articles/s4169…
A thread:
1/n
We would really like to hear your thoughts (including but not exclusively @paulpharoah @ewanbirney @GENES_PK @antonis02 @DJHunter_EPI @EricTopol @nilanjan10c @cecilejanssens @VPrasadMDMPH @DrSidMukherjee @genandgenes @hannah_wand @chris_wigley @CharlesSwanton @d_spiegel)
2/n
2/n
Genome-wide associations studies (GWAS) have identified associations between many #genetic variants and cancer #risk:
nature.com/articles/nrc.2…
3/n
nature.com/articles/nrc.2…
3/n
(Thread 1/n) The Future of Health & #Medicine: Where Can Technology Take Us?
@daniel_kraft eloquently summarizes the early innings of #healthcare #technology, and its #future. #mustwatch
$XBI $IBB
My favorite takeaways below:
@daniel_kraft eloquently summarizes the early innings of #healthcare #technology, and its #future. #mustwatch
$XBI $IBB
My favorite takeaways below:
(Thread 2/n) The Future of Health & Medicine:
Where Can Technology Take Us?
Some companies discussed: $TDOC $DRIO $GDRX $AMZN $UBER $AAPL $FIT $AMWL $GOOGL
$GRMN $DXCM $TNDM
@TeladocHealth (I think) would be wise to purchase
@DetectTest @VitalConnectInc @TytoCare @HeartFlow
Where Can Technology Take Us?
Some companies discussed: $TDOC $DRIO $GDRX $AMZN $UBER $AAPL $FIT $AMWL $GOOGL
$GRMN $DXCM $TNDM
@TeladocHealth (I think) would be wise to purchase
@DetectTest @VitalConnectInc @TytoCare @HeartFlow
(Thread 3/n) The Future of Health & Medicine
Glucose Monitoring paving the path forward.
Diabetes care started the path forward. Wearable monitoring, is still in it's infancy. What other applications will come?
@dexcom
@TandemDiabetes
@DarioHealth
@TeladocHealth @Livongo
Glucose Monitoring paving the path forward.
Diabetes care started the path forward. Wearable monitoring, is still in it's infancy. What other applications will come?
@dexcom
@TandemDiabetes
@DarioHealth
@TeladocHealth @Livongo
BCG analyzed 🔬 🇺🇸, 🇫🇷 , 🇩🇪 , 🇮🇹, 🇪🇸 Outlook
Testing's likely to follow similar trajectories
Peak COVID demand occurring in the seasonally affected first quarters of 2021 & 2022
#Novacyt #ALNOV #NCYT
bcg.com/en-in/publicat…
Testing's likely to follow similar trajectories
Peak COVID demand occurring in the seasonally affected first quarters of 2021 & 2022
#Novacyt #ALNOV #NCYT
bcg.com/en-in/publicat…
It changes everything about what we understand, this virus is bit too much for mankind. Challenges aplenty but #Science will take us through !
Much needed Update From @mvankerkhove
On the #Antigenicdrift and possible implications on #vaccine
Our nation-wide study on the #genomic #epidemiology of #SARS-CoV-2 #superspreader_events in #Austria is out in @ScienceTM !
doi.org/10.1126/scitra…
Please find the highlights in this thread. 1/8
doi.org/10.1126/scitra…
Please find the highlights in this thread. 1/8
Through #Phylogenetic #SARSCoV2 analyses and data integration with @GISAID @nextstrain , we unveiled the links between #Austrian clusters to the global #pandemic. Explore our data and data-driven narratives at #NextstrainAustria sarscov2-austria.org ! 2/8
#Epidemiological and #Phylogenetic data revealed the geographic origins and distributions of SARS-CoV-2 in Austria. Different viruses circulated in the ski-resort region of #Ischgl with the most dominant #Tyrol-1 linked to @nextstrain clade 20C. 3/8
🎉CELEBRATION ALERT!! We reached 10K followers @NatureCancer - massive thank you to our wonderful community for the warm welcome! Given it is also 10 months of our online life, here are some of our best articles (although all are *fantastic*) #thread 1/n
#10atNatureCancer
#10atNatureCancer
January @NatureCancer: Nabel &co @SanofiUS develp #trispecific antibodies against CD3, CD28 and CD38, with preclinical efficacy and safety in humanized mice and NHPs 2/n
go.nature.com/30GlQyH
rdcu.be/b78Zr
#10atNatureCancer
go.nature.com/30GlQyH
rdcu.be/b78Zr
#10atNatureCancer
February @NatureCancer: Golub and Co @broadinstitute develop PRISM, a tool for non-oncology drug repurposing in #cancer 3/n
go.nature.com/36zCxQh
rdcu.be/b78ZE
#10atNatureCancer
go.nature.com/36zCxQh
rdcu.be/b78ZE
#10atNatureCancer
Rapid whole genome (🧬) sequencing (rWGS) is one of the most exciting (and benevolent) collisions of #AI and #genomics I can think of.
rWGS can diagnose a critically ill child in minutes where previously it took years.
illumina.com/company/news-c…
rWGS can diagnose a critically ill child in minutes where previously it took years.
illumina.com/company/news-c…
A few years ago, Illumina ($ILMN) and Rady Children's Hospital (@RadyGenomics) collaborated to offer sequencing services for diagnosing critically-ill infants and toddlers.
Roughly 70% of rare diseases are genetic and they can take five years to diagnose.
Roughly 70% of rare diseases are genetic and they can take five years to diagnose.
As sequencing costs dropped and #AI got faster, this collaboration became Project Baby Bear: a pilot study for rWGS's diagnostic yield, clinical utility, and health economics in practice.
Several innovative companies joined Rady's in creating a rapid diagnostic pipeline.
Several innovative companies joined Rady's in creating a rapid diagnostic pipeline.
#RareDiseases are not rare. One example is Hyper-IgD Syndrome, an #autoinflammatory / #PrimaryImmunodeficiency disease. Wonderful collaboration extending over 5 years between Kozhikode Medical College, CMC Vellore and CSIR-IGIB as part of the #GUaRDIAN journals.plos.org/plosone/articl…
Our #genomic analysis suggests that a few variants account for the majority of the patients with HIDS in South #India with implications in #diagnosis, as well as in the development of cost-effective approaches for #genetic #diagnosis and #screening
@Primary_Immune @MoHFW_INDIA
@Primary_Immune @MoHFW_INDIA
📢🎉The work of #Bat1K is featured on the cover in the latest issue of @nature: “Six reference-quality #genomes reveal evolution of #bat adaptations” 🦇🧬 #bats Our thread 👇 on the paper:nature.com/articles/s4158… 📸: Olivier Farcy(1/n)
📢Have you ever wondered how 🦇 manage to do what they do? #bats have extraordinary adaptations, including powered #flight, laryngeal #echolocation, #vocal #learning and an exceptional #longevity with unique #immunity and resistance to #cancer! 📸: @DanielWhitby5 (2/n)
A #Bat1K team led by @Sonja_Vernes @EmmaTeeling1 @hillermich @TheGeneMyers has just published the raw genetic material that codes for these unique 🦇 adaptations and #superpowers in @nature! #bats #genomics #cool! (3/n)
Check out the latest preprint from the lab on "Integration of #Genomic & Multi-tissue #proteomic data in neurodegenerative diseases" lead by @chengran2020 @WUSTLdbbs in @ccrugom lab at @WUSTLmed supported by @cziscience via @medrxivpreprint medrxiv.org/content/10.110… #tweetorial ⬇️
This is the first #proteomic study that uses high throughput pQTL in neurological relevant tissues to identify novel genetic loci regulating protein levels, which will improve our understanding of the biology of #Alzheimers, #Parkinsons, & other neurodegenerative diseases
We identified hundreds of novel pQTLs in CSF, plasma, & Brain linking novel genes, biomarkers and drug targets with #Alzheimers, #Parkinsons
"The live SARS-like coronavirus SL-CoV-WIV1 has been isolated for the first time from bat droppings; and such virus has been confirmed to invade the host cells through the ACE2 of human beings..."
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964
In this study, we have developed a fast and cost-effective method
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily.
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily.
Just published: A new 5-paper Series, with contributions from @genome_gov, focuses on the exciting and maturing area of #genomicmedicine, encompassing the use of individuals’ genetic information to guide clinical treatment hubs.ly/H0k35bk0
@genome_gov @NIH @GenomicsEngland "As this Series emphasises, #genomics is now an essential part of high-quality patient care in rare disease, cancer & those areas of mainstream medicine where pharmacogenomics & the need for precision diagnostics is growing." Comment by M Caulfield et al hubs.ly/H0k6Q-M0
@genome_gov @NIH @GenomicsEngland @QMUL @QMULWHRI @GreatOrmondSt "I see genomics as providing another way of assessing risk and enabling better management of our patients"
Profile: Teri Manolio, Director of Genomic Medicine at @genome_gov & lead author of our new Series on #genomicmedicine hubs.ly/H0k7Pd00
Profile: Teri Manolio, Director of Genomic Medicine at @genome_gov & lead author of our new Series on #genomicmedicine hubs.ly/H0k7Pd00
