Discover and read the best of Twitter Threads about #Phylogenetic
Most recents (12)
😂
Some real talk:
It can be difficult to tell with certainty whether a random virus is engineered or not based purely on the sequence, but when we talk about a specific virus, e.g. SC2, we were 'lucky' that we can tell with high certainty it is a natural virus.
Why?
1/
Some real talk:
It can be difficult to tell with certainty whether a random virus is engineered or not based purely on the sequence, but when we talk about a specific virus, e.g. SC2, we were 'lucky' that we can tell with high certainty it is a natural virus.
Why?
1/
We were lucky in the sense that coronaviruses evolve through recombination (not only random mutations & selection).
That means their genomes consist of a patchwork of puzzle pieces assembled by crossings paths with other CoVs.
In SC2's case, we talking like 27 recombination pc
That means their genomes consist of a patchwork of puzzle pieces assembled by crossings paths with other CoVs.
In SC2's case, we talking like 27 recombination pc
Each piece comes with its own evolutionary history and can be mapped on a #phylogenetic family tree based on common ancestors & cousin viruses.
This allows researchers to figure out what "crossing events" lead to SC2 genome by sampling CoVs in the wild
academic.oup.com/gbe/article/14…
This allows researchers to figure out what "crossing events" lead to SC2 genome by sampling CoVs in the wild
academic.oup.com/gbe/article/14…
🧵#Bioinformatics and its impact on #healthcare, a THREAD🧵🧵:
#Bioinformatics is the application of #computational techniques to the analysis of #biological data, such as #DNA sequences and #protein #structures.
In #healthcare, #bioinformatics is used to gain insights into the #genetic basis of diseases, and to develop new #diagnostic tests and #treatments.
Are you interested in getting started in #bioinformatics but not sure where to begin? Here are some tips to help you get started on your journey. A THREAD🧵🧵:
Start by learning a high-level #programming language, such as #Python or #R, and familiarizing yourself with data structures and #algorithms commonly used in #bioinformatics. The #BioPython and #Bioconductor libraries are great resources for this.
🧬🧵here is a Twitter thread explaining #Bioinformatics in simple terms:🧬🧵
#Bioinformatics is the field that uses computational tools and methods to analyze and interpret #biological #data.
This can include analyzing #DNA and #protein #sequences, predicting the structure and function of #molecules, and modeling biological systems.
1/5 #Deforestation is leading to increasingly #fragmented landscapes🌲
Aim: How do #bats respond to changes in local habitat quality and fragmentation of the wider landscape via investigation of 3 holistic diversity facets #taxonomic, #functional, #phylogenetic🦇
#WBTC #Land1
Aim: How do #bats respond to changes in local habitat quality and fragmentation of the wider landscape via investigation of 3 holistic diversity facets #taxonomic, #functional, #phylogenetic🦇
#WBTC #Land1
2/5 Data from #BDFFP in Central #Amazon 🇧🇷 largest & longest running ecological (+40 y/s) study of #fragmentation
• Field work by: @adria_baucells @RicardoNature
• When: 2011-2013
• Sites: 33
• Acoustic data: 281,664 calls
• #Bat Species: 21 🦇
• Families: 5
#WBTC2 #Land1
• Field work by: @adria_baucells @RicardoNature
• When: 2011-2013
• Sites: 33
• Acoustic data: 281,664 calls
• #Bat Species: 21 🦇
• Families: 5
#WBTC2 #Land1
3/5 #Taxonomic, #functional & #phylogenetic metrics based on #acoustic data were related to local vegetation descriptors & landscape-scale habitat composition & configuration variables using #GLMMs.
#WBTC2 #Land1
#WBTC2 #Land1
#OneYearAgo a "coronavirus #genome from a case of a respiratory disease from the #Wuhan outbreak" was published on #GenBank... 🧐#SARSCoV2
#OneYearAgo "The cluster of infections had raised fears of a potential epidemic after China said last week that the virus causing it was a previously unknown type but came from the same family of viruses that caused the #SARS and #MERS epidemics".🧐
reuters.com/article/us-hea…
reuters.com/article/us-hea…
#OneYearAgo It was suddenly clear that the virus was travelling fast... any bell ringing?🧐#covid19
cidrap.umn.edu/news-perspecti…
cidrap.umn.edu/news-perspecti…
Our nation-wide study on the #genomic #epidemiology of #SARS-CoV-2 #superspreader_events in #Austria is out in @ScienceTM !
doi.org/10.1126/scitra…
Please find the highlights in this thread. 1/8
doi.org/10.1126/scitra…
Please find the highlights in this thread. 1/8
Through #Phylogenetic #SARSCoV2 analyses and data integration with @GISAID @nextstrain , we unveiled the links between #Austrian clusters to the global #pandemic. Explore our data and data-driven narratives at #NextstrainAustria sarscov2-austria.org ! 2/8
#Epidemiological and #Phylogenetic data revealed the geographic origins and distributions of SARS-CoV-2 in Austria. Different viruses circulated in the ski-resort region of #Ischgl with the most dominant #Tyrol-1 linked to @nextstrain clade 20C. 3/8
📢🎉The work of #Bat1K is featured on the cover in the latest issue of @nature: “Six reference-quality #genomes reveal evolution of #bat adaptations” 🦇🧬 #bats Our thread 👇 on the paper:nature.com/articles/s4158… 📸: Olivier Farcy(1/n)
📢Have you ever wondered how 🦇 manage to do what they do? #bats have extraordinary adaptations, including powered #flight, laryngeal #echolocation, #vocal #learning and an exceptional #longevity with unique #immunity and resistance to #cancer! 📸: @DanielWhitby5 (2/n)
A #Bat1K team led by @Sonja_Vernes @EmmaTeeling1 @hillermich @TheGeneMyers has just published the raw genetic material that codes for these unique 🦇 adaptations and #superpowers in @nature! #bats #genomics #cool! (3/n)
Our collaborative study unravels #SARSCoV2 #SuperSpreader events in #Austria and the inter- and intra-host mutational dynamics.
Preprint at @biorxivpreprint available now: biorxiv.org/content/10.110… !
1/7
Preprint at @biorxivpreprint available now: biorxiv.org/content/10.110… !
1/7
Through #Phylogenetic #SARSCoV2 analyses and data integration with @GISAID @nextstrain , we unveiled the links between #Austrian clusters to the global #pandemic.
Explore our data and data-driven narratives at #NextstrainAustria cemm.at/research/sars-… !
2/7
Explore our data and data-driven narratives at #NextstrainAustria cemm.at/research/sars-… !
2/7
With #Epidemiological and #Phylogenetic data we investigated the geographic origins and distributions of SARS-CoV-2 in Austria. Different viruses circulated in the ski-resort region of #Ischgl with the most dominant #Tyrol-1 linked to @nextstrain clade 20C.
3/7
3/7
#Occupy: A #MUST (long-) #READ !
Search for Truth on #Origin of #COVID19.
#Questions needing #Answers.
The #Truth has to come out.
We need ONE MORE #Brave #Edward #Snowdon
or #Chelsea #Manning, another #HERO
to leak the information.
>veteranstoday.com/2020/04/02/fac… <-via @veteranstoday
Search for Truth on #Origin of #COVID19.
#Questions needing #Answers.
The #Truth has to come out.
We need ONE MORE #Brave #Edward #Snowdon
or #Chelsea #Manning, another #HERO
to leak the information.
>veteranstoday.com/2020/04/02/fac… <-via @veteranstoday
#Occupy: Serial: "The #Crumbling #Empire".
Episode: "#Final #Blow by a #Feral #Biowar-#Virus".
Despite #WHO obligations, the Empire's #CDC
refuses to #Show its #COVID19-#Origin-Patient Zero,
#Attacks the WHO itself & anyone requesting that information.
->unz.com/article/the-hu…
Episode: "#Final #Blow by a #Feral #Biowar-#Virus".
Despite #WHO obligations, the Empire's #CDC
refuses to #Show its #COVID19-#Origin-Patient Zero,
#Attacks the WHO itself & anyone requesting that information.
->unz.com/article/the-hu…
#Occupy: In Search of #Truth on the #Origin of #SARS_CoV_2.
The original #Strain, "A"
is not the Main-strain in China (= "B")
and is also found in the #US & #Australia.
#Genetic network analysis provides "snapshot"
of #COVID19-#Pandemic #Origins:
->shar.es/aHYg0X
The original #Strain, "A"
is not the Main-strain in China (= "B")
and is also found in the #US & #Australia.
#Genetic network analysis provides "snapshot"
of #COVID19-#Pandemic #Origins:
->shar.es/aHYg0X
La propagation de l'épidémie en France.
🔹On constate deux importations d'Italie.
🔹La seconde plus tardive en Alsace a bénéficié d'un événement de super-spreading lors de la réunion évangélique.
#phylogenetic #SARSCoV2 #covid19 @nextstrain nextstrain.org/ncov?c=gt-nuc_…
🔹On constate deux importations d'Italie.
🔹La seconde plus tardive en Alsace a bénéficié d'un événement de super-spreading lors de la réunion évangélique.
#phylogenetic #SARSCoV2 #covid19 @nextstrain nextstrain.org/ncov?c=gt-nuc_…
Pourquoi j'affirme que le sous-arbre vert est celui de Mulhouse : les dates, les lieux, l'homme de 86 ans à Thise nextstrain.org/ncov?s=France/… macommune.info/coronavirus-10…
Le fait qu'il y a deux gros foyers épidémiques bien identifiés en France : IDF et Alsace.
Le fait qu'il y a deux gros foyers épidémiques bien identifiés en France : IDF et Alsace.
It’s out! Our paper “Marine Sediments Illuminate Chlamydiae Diversity and Evolution” was published in @CurrentBiology today! Below a thread with major highlights 1/11
cell.com/current-biolog…
cell.com/current-biolog…
Big thanks to fantastic co-authors! Celebrating with @DanielTamarit, @eme_laura, @cstairs, @JoranMartijn, @hfixou, Steffen Jørgensen, @anjspa1, and @Ettema_lab. Work done @MolEvoUpp, @MIB_WUR, and @uibgeo.
For a visual summary, check out our graphical abstract 2/11
For a visual summary, check out our graphical abstract 2/11
In short: Phylogenetically diverse new lineages of #Chlamydiae (a bacterial phylum which includes the pathogen #Chlamydia) are abundant and active in deep #anoxic #marine #sediments taken from near Loki’s Castle #hydrothermal vent field 3/11
