Discover and read the best of Twitter Threads about #ClinicalResearch
Most recents (19)
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1/18
We at HCC are so proud of our team and participating centers. 6 abstracts of our collective work have been accepted for #ASH22. If you wish to be a part of this movement either as an individual or as a participating institution, do visit us at hemecancer.org/membership.php
1/18
We at HCC are so proud of our team and participating centers. 6 abstracts of our collective work have been accepted for #ASH22. If you wish to be a part of this movement either as an individual or as a participating institution, do visit us at hemecancer.org/membership.php
@chepsyphilip @pb10_bmt @udaypkulkarni @NancyArthurPhD @DrArunCMC @dranupjdevasia @DrNikitaMehra @faheema_hasan @madhavi_maddali @jayastuMD @MJosephJohn1 @dbhurani @lingarajnayak @Prasshmehta @hkJain_kmc @b_poonkuzhali @nvpatkar @rayaz_hemat @drmanuprasad
2/18
#2976 Prognostic Factors and Outcomes of Adolescent and Adult Burkitt Lymphoma and Leukemia from a Low-Middle Income Country: An Experience from Hematology Cancer Consortium
ash.confex.com/ash/2022/webpr…
#2976 Prognostic Factors and Outcomes of Adolescent and Adult Burkitt Lymphoma and Leukemia from a Low-Middle Income Country: An Experience from Hematology Cancer Consortium
ash.confex.com/ash/2022/webpr…
1/5 @pancreatitis_nl trials addressing the management of infected pancreatic necrosis in acute pancreatitis #TheAmylaseSchool @my_ueg @EurPancClub @MarcBesselink #ClinicalResearch
2/5
Panther trial: A Step-up Approach or Open Necrosectomy for Necrotizing Pancreatitis @NEJM
This trial robustly demonstrated that minimally invasive treatment (percutaneous drainage and minim. invasive surgery if needed) was better than open surgery
nejm.org/doi/10.1056/NE…
Panther trial: A Step-up Approach or Open Necrosectomy for Necrotizing Pancreatitis @NEJM
This trial robustly demonstrated that minimally invasive treatment (percutaneous drainage and minim. invasive surgery if needed) was better than open surgery
nejm.org/doi/10.1056/NE…
3/5 Penguin trial: Endoscopic Transgastric vs Surgical Necrosectomy for Infected Necrotizing Pancreatitis @JAMA_current jamanetwork.com/journals/jama/… This trial showed that endoscopic necrosectomy was better (less aggressive) than open surgery
I am a recent but huge fan of @Freakonomics podcast. I've also been enjoying @DrBapuPod by @AnupamBJena
Episode today was about #ArtificialIntelligence in #medicine and I want to share my concerns about the discussion on racial disparities in knee pain (starting at 19:00)
A 🧵
Episode today was about #ArtificialIntelligence in #medicine and I want to share my concerns about the discussion on racial disparities in knee pain (starting at 19:00)
A 🧵
#1 - The suggestion that only pain that can be explained by pathology seen on a knee xray is "real, organic, genuine" and other pain is "in someone's head" is hugely problematic and detrimental to patients seeking care for #Chronicpain and providers.
nature.com/articles/s4159…
nature.com/articles/s4159…
This is not aligned with the role of nervous system sensitization, psychological factors, and other mechanisms underlying the chronic pain experience.
Imp to note that #machinelearning model from xrays explained only 16% of variability in pain overall
@NatureMedicine @oziadias
Imp to note that #machinelearning model from xrays explained only 16% of variability in pain overall
@NatureMedicine @oziadias
Just a friendly reminder @moderna_tx told the @SECGov that the @US_FDA defines #mRNA as gene therapy. And called it an unprecedented new category of #medicines tho they really want that #vaccine classification anyways for liability protections & fear the public wouldn’t take it.
In a recent lung cancer pilot study, we identified and quantified a record number of 13,187 protein groups with our next-generation single-shot proteomics technology HRM.
This was achieved using FAIMS-DIA with highest resolution chromatography and FAIMS Exploris 480. (1/n)
This was achieved using FAIMS-DIA with highest resolution chromatography and FAIMS Exploris 480. (1/n)
The depth of analysis was superior to the one achieved in the Deep Human Proteome Atlas (deep fractionated tissue with multiple MS acquisitions, Wang et al., 2019, Mol Syst Biol).
Comprehensively, we could identify 414 oncogenes, 392 transcription factors, 837 plasma membrane proteins (25 GPCR), and 316 kinases covering a dynamic range of 10. In addition, 0.25 Mio peptides (including modifications) were measured in totality.
#tweetorial 🧵
🚩Metabolism and Acute Myeloid Leukemia
(1/23)
➡️📈🔎Increased attention over the last decade on the metabolic perturbations in AML
➡️Potential therapeutic implications – with ‘druggable’ targets
🚩Metabolism and Acute Myeloid Leukemia
(1/23)
➡️📈🔎Increased attention over the last decade on the metabolic perturbations in AML
➡️Potential therapeutic implications – with ‘druggable’ targets
(2/23)
➡️🗒️📌Summary of recent concepts
🔊IT IS ALL HAPPENING IN THE MITOCHONDRIA
👉📈🏹Increase potential of targeting the mitochondria
👉🦀Anti-cancer agents specifically targeting cancer cell mitochondria are referred to as 'mitocans'
➡️🗒️📌Summary of recent concepts
🔊IT IS ALL HAPPENING IN THE MITOCHONDRIA
👉📈🏹Increase potential of targeting the mitochondria
👉🦀Anti-cancer agents specifically targeting cancer cell mitochondria are referred to as 'mitocans'
(3/23)
➡️Metabolic adaptions of AML cells
AML is a 🦀cancer derived from the myeloid lineage of blood🩸cells, characterized by overproduction of malignant cells.
➡️Metabolic adaptions of AML cells
AML is a 🦀cancer derived from the myeloid lineage of blood🩸cells, characterized by overproduction of malignant cells.
#tweetorial 🧵
➡️Ph-like ALL / BCR-ABL1-like ALL
👉A provisional entity in the 2016 World Health Organization classification of acute leukemia 🩸🩸
👉Gene expression 🧬signature similar to Ph-positive ALL but lacks the BCR-ABL1 translocation
@NancyArthurPhD
➡️Ph-like ALL / BCR-ABL1-like ALL
👉A provisional entity in the 2016 World Health Organization classification of acute leukemia 🩸🩸
👉Gene expression 🧬signature similar to Ph-positive ALL but lacks the BCR-ABL1 translocation
@NancyArthurPhD
➡️Originally defined by gene expression 🧬profiling in 2009 by 2 groups
👉Children's Oncology Group (COG) and St. Jude Children's Research Hospital (referred to as Ph-like ALL) 👉Dutch Childhood Oncology Group (referred to as BCR-ABL1-like ALL) – DCOG/COALL
👉Children's Oncology Group (COG) and St. Jude Children's Research Hospital (referred to as Ph-like ALL) 👉Dutch Childhood Oncology Group (referred to as BCR-ABL1-like ALL) – DCOG/COALL
👉The differences in the approaches are outlined in the figure; more on the gene expression 🧬 signatures and diagnostic conundrums later!
We're thrilled to announce that PREVENT-19 (US/Mex Phase 3) results were submitted for publication. The manuscript is now available as a pre-print. Let's dive into what we found. Thread: medrxiv.org/content/10.110…
PREVENT-19 builds on observations from other/ongoing #clinicaltrials, investigating the safety & efficacy of NVX-CoV2373 in the United States and Mexico amidst an evolving #COVID19 pandemic. ir.novavax.com/2021-08-05-Nov…
The trial randomized adults age 18+ in a 2:1 ratio to receive 2x 5μg doses of NVX-CoV2373, our investigational #vaccine candidate, or placebo, 21 days apart. novavax.com/sites/default/…
"VEXAS SYNDROME", a multidisciplinary team of researchers @genome_gov have identified this new disorder:
(1/8)
➡️Monogenic adult-onset autoinflammatory disease affecting males ♂️👨👦
(1/8)
➡️Monogenic adult-onset autoinflammatory disease affecting males ♂️👨👦
(2/8)
➡️Caused by a mutation in the UBA1 gene 🧬 that encodes major E1 enzyme that initiates ubiquitylation
➡️Suggests postzygotic somatic mutation may be a more frequent cause of human disease👨
➡️Patients develop inflammatory symptoms🔥and hematological abnormalities🩸👇
➡️Caused by a mutation in the UBA1 gene 🧬 that encodes major E1 enzyme that initiates ubiquitylation
➡️Suggests postzygotic somatic mutation may be a more frequent cause of human disease👨
➡️Patients develop inflammatory symptoms🔥and hematological abnormalities🩸👇
(3/8)
🔥🔥INFLAMMATORY SYMPTOMS
👉Fatigue 😫
👉Recurrent fever 🤒🌡️
👉Lung infiltrates 🫁
👉Skin lesions🔴
👉Ear chondritis👂
👉and vasculitis
🔥🔥INFLAMMATORY SYMPTOMS
👉Fatigue 😫
👉Recurrent fever 🤒🌡️
👉Lung infiltrates 🫁
👉Skin lesions🔴
👉Ear chondritis👂
👉and vasculitis
I’m excited to launch @ABPI_UK's new report into the UK’s clinical research landscape (and my first as Head of Research Policy @ABPI_UK!) Here are my 6 takeaways 🧵...
1⃣ The UK has gone above and beyond when it comes to COVID-19 research with 6⃣8⃣ studies delivered in 2020 – the highest in Europe! 🔬🧪
2⃣When it comes to #GlobalBritain, only 🇺🇸 & 🇧🇷 started more C-19 trials in 2020. More broadly, the UK also punches above its weight in early phase research, maintaining its European lead in Phase I trials 🏆
Over the last year we’ve been voicing our charities’ stance on clinical research issues and helping to shape initiatives that influence the #clinicalresearch ecosystem.
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When the pandemic hit, AMRC charities were forced to stop, pause, or delay 73% of the clinical trials and studies they fund to support the secondment of clinical research staff to the NHS frontline & the delivery of COVID-19 research.
Apr 2020: We worked with @NIHRresearch to develop a framework (bit.ly/2SPVwBd) to restart research. We also engaged with the Life Science Council’s Clinical Research Working Group & contributed to their report on transforming the UK clinical research environment.
SO proud of our team for hosting the annual HeART of Science Workshop this weekend to celebrate American Heart Month!
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On Saturday, we taught a group of over 70 children (ages 5-12 years old) about heart health and led them in demonstrations of two of the biggest surgical advances in the treatment of heart disease.
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Many thanks to our wonderful guest speakers Aryn Knight, research director at Texas Heart Institute and Dr. Bill Chu, Medical Director at @NightLightPedi for sharing your knowledge.
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Dr. Cook begins her #CCC50 Lifetime Achievement Award talk with reflection on her own 1st presentation ever as an #ICU fellow- at an @SCCM Congress! She was struck by the interprofessional group of attendees.(Thread)
#NationalWomenPhysiciansDay #WomenInMedicine #clinicalresearch
#NationalWomenPhysiciansDay #WomenInMedicine #clinicalresearch
Her first lesson learned to impart to us.
BE BRAVE.
An early senior researcher said to her early in career:
"I just don't think research is in your future"
Imagine what #CriticalCare world would have lost if she had listened.
#CCC50 #pulmcc #PedsICU
BE BRAVE.
An early senior researcher said to her early in career:
"I just don't think research is in your future"
Imagine what #CriticalCare world would have lost if she had listened.
#CCC50 #pulmcc #PedsICU
Dr. Cook: Sometimes dialogue is more important than consensus. You have the TRUST YOUR GUT. #CCC50
You're not growing until you're changing. Defining moments for bravery may come along when you least expect them. Be brave. #WomensPhysicianDay #PedsICU #pulmcc #ICU
You're not growing until you're changing. Defining moments for bravery may come along when you least expect them. Be brave. #WomensPhysicianDay #PedsICU #pulmcc #ICU
Not only experience, which is important, but clinical #research does not parse out the Japanese man or woman from the South Asian man or woman on heart disease risk, epidemiology, treatment.
#EBM lacking for us then
#MedTwitter #AcademicTwitter #AcademicChatter
#EBM lacking for us then
#MedTwitter #AcademicTwitter #AcademicChatter
And then there is the question of who is white.
Iranian/Persian & Arabs are white on census.
Does the rest of America agree?
Racists & xenophobes tend to use loophole to say being anti-Muslim (whom they consider to all be Arab) is “not racist.”
latimes.com/projects/la-me…
Iranian/Persian & Arabs are white on census.
Does the rest of America agree?
Racists & xenophobes tend to use loophole to say being anti-Muslim (whom they consider to all be Arab) is “not racist.”
latimes.com/projects/la-me…
Proving again: race is a social construct
Not until 2020 Persians really started to call selves “POC” (for self protection)
Have lots of Persian friends
Urdu culture has Farsi roots
But let’s be honest: Persians have seen selves as superior race, apart
wbez.org/stories/renewe…
Not until 2020 Persians really started to call selves “POC” (for self protection)
Have lots of Persian friends
Urdu culture has Farsi roots
But let’s be honest: Persians have seen selves as superior race, apart
wbez.org/stories/renewe…
ATTN #CBD stakeholders: @US_FDA today holding scientific conf. on CBD/other #cannabinoids. I'll be live tweeting throughout. Not sure we'll get much insight on immediate path forward for consumer products but I'll share noteworthy observations. Agenda: bit.ly/3pHXU8V
I'll be paying particular attention to @DrAbernethyFDA's remarks at 9:05a (head of #FDA's #CBD Policy Working Group) and @DThrockmortonMD's keynote at 9:15a (one of Agency's principals for regulating R&D, manufacture & marketing of #cannabis & cannabis-derived #drug products).
Good morning everyone, it’s @SDonatta on the account today, talking all things #research and #researchnurses alongside @HeatherB18 and @Sammycad77 join us @WeStudentNurse @WeNurses @UHBResearch #HCPnetwork #whywedoresearch
But first #tea . What’s your brew of choice?
My first job in #research was as a #clinicaltrialsassistant during my uni years and I quickly learnt it was different from the research taught at university as part of #nursing curriculum #HCPnetwork
Its Sunday and we’re doing a long thread on past medical abuses against Black communities to try to help science Twitter understand why “trust” is not the goal – the goal is empowerment. #blacklivesmatterinhealthtoo
When we talk about representation of Black folks in #clinicalresearch, the term “trust” is often used. “Trust” is too big a barrier and it can easily go away. The feeling is, “We’ve tried, but it’s too hard.”
But leaving communities out of advances in medicine is not the answer – we’re seeing the deadly results of this in #COVID19. But, still, we need to talk about why there is a lack of trust and why that is deserved. theatlantic.com/ideas/archive/…
These are a few of the questions I am often asked by junior physicians, or even peer physicians. I thought I’d share with you some the top 10 pearls I share with others, as we focus on many of these in the Brave Enough Master Class. #tweetorial #medicalstudents #medicalschool
1. Give your family your best. Give your work the rest. - @dalepartrigde #tweetorial #medicine #mentor #physicianwomen #womeninmedicine #medicalschool #residents #medicalstudents #healthcare #blog #blogger
#author #braveenough #gritandgrace
#author #braveenough #gritandgrace
2. Take a vacation every 3 months. Especially in the first few years. Trust me. Time away = burnout prevention. #tweetorial #medicine #mentor #physicianwomen #womeninmedicine #medicalschool #residents #medicalstudents #author #braveenough #gritandgrace #burnoutsyndrome #selfcare
1/ #ClinicalResearch Primer
A personal hands-on experince:
You’re interested in causes of ARDS & transfusion comes up. Literature review=many ?s: Is it the reason for transfusion or transfusion itself? Is it just fluid? Is it RBC or plasma. Is it “storage lesion” or antibodies?
A personal hands-on experince:
You’re interested in causes of ARDS & transfusion comes up. Literature review=many ?s: Is it the reason for transfusion or transfusion itself? Is it just fluid? Is it RBC or plasma. Is it “storage lesion” or antibodies?
2/ You dig deeper and find some fascinating studies largely known only by transfusion specialists:
ncbi.nlm.nih.gov/pubmed/4071603
ncbi.nlm.nih.gov/pubmed/11960539
You get your feet wet in a retrospective cohort study using a standardized definition (for the first time) ncbi.nlm.nih.gov/pubmed/16965572
ncbi.nlm.nih.gov/pubmed/4071603
ncbi.nlm.nih.gov/pubmed/11960539
You get your feet wet in a retrospective cohort study using a standardized definition (for the first time) ncbi.nlm.nih.gov/pubmed/16965572
3/ You learn it is plasma rather than red cells:
ncbi.nlm.nih.gov/pubmed/17400669
ncbi.nlm.nih.gov/pubmed/16276195
and the storage duration (fresh vs old) does not matter:
ncbi.nlm.nih.gov/pubmed/22281833
ncbi.nlm.nih.gov/pubmed/17400669
ncbi.nlm.nih.gov/pubmed/16276195
and the storage duration (fresh vs old) does not matter:
ncbi.nlm.nih.gov/pubmed/22281833
