Discover and read the best of Twitter Threads about #Clinical
Most recents (24)
1/@LineageCell announced it entered an exclusive option & license agreement with $ERNA for the development of novel B2M deficient induced pluripotent #stem #cell #iPSC by using Eterna’s #GeneEditing technology thus developing therapies for #CNS diseases. #BioTech #CRISPR $LCTX 
2/The new cell lines - to be developed by $ERNA, will support the creation of additional product candidates at $LCTX and specifically for the treatment of central #nervoussystem #CNS disorders & other #neurology targets via Eterna’s IP #CRISPR collaboration with @FactorBio
3/This agreement will also allow @LineageCell to enter the #CRISPR field and will provide $LCTX an option to obtain an exclusive license to utilize & sublicense $ERNA novel #GeneEditing cell lines for #preclinical, #clinical, & commercial purposes in the field of CNS diseases.
Great to see my #review on #pharmacogenomics in @NatureRevGenet. rdcu.be/c4iur
@BritPharmSoc @LivUni @pandtuol @CDSS_Liverpool @pgrnhub @pharmgkb @nwgmsa @LivUniISMIB
Key messages:
@BritPharmSoc @LivUni @pandtuol @CDSS_Liverpool @pgrnhub @pharmgkb @nwgmsa @LivUniISMIB
Key messages:
A. Wider definition of #pharmacogenomics
B. Pharmacogenomic #variation is common, we are exposed to many #drugs which require pharmacogenomic #guidance
C. There is increasing #evidence of #clinical #utility of #PGx
B. Pharmacogenomic #variation is common, we are exposed to many #drugs which require pharmacogenomic #guidance
C. There is increasing #evidence of #clinical #utility of #PGx
D. We need more studies on #diversity in #PGx
E. The time is right for #implementation of #PGx #personalised #prescribing
bps.ac.uk/getmedia/b43a3…
E. The time is right for #implementation of #PGx #personalised #prescribing
bps.ac.uk/getmedia/b43a3…
1/ A THREAD on what $PVCT achieved in 2022. #event #discovery #milestone #milepost. #rosebengal #rosebengalsodium.
3/ $PVCT #clinical and #research collaborators made 6 presentations at 5 medical conferences about PV-10 for different cancers. #ENETS22 #AACR22 #ASCO22 #ISOO2022 #melanomabridge. #presentations. #rosebengal #rosebengalsodium.
Resources to study #Neurology
Adams and Victor’s. By far my favourite textbook.
The book is more clinically oriented, coloured with anecdotes and mental models. Reading it feels like seeing a pt in the ward/OPD
#MedTwitter #neurotwitter
Adams and Victor’s. By far my favourite textbook.
The book is more clinically oriented, coloured with anecdotes and mental models. Reading it feels like seeing a pt in the ward/OPD
#MedTwitter #neurotwitter
It has elements of philosophy, history and is written eloquently.
Whimsical, yet profound, it’s teachings stay with me. Added bonus, my Guru in Neurology finds mention in the text 🙃 I’d recommend this for #mbbs #md and #dm students
Whimsical, yet profound, it’s teachings stay with me. Added bonus, my Guru in Neurology finds mention in the text 🙃 I’d recommend this for #mbbs #md and #dm students
Bradley is the standard #textbook in #neurology. A great book, it’s more like #Harrison. Great for information, latest research and management. Essential for the DM #neurology candidate, but also useful for MD #internalmedicine
A woman who had a constant urge to move her right leg while sitting or lying down
1. 42-year old woman consulted me last month with complaints of constant urge to move her right leg for past 12 years. Symptoms occurred mostly in evenings and nights.
#MedTwitter #neurotwitter
1. 42-year old woman consulted me last month with complaints of constant urge to move her right leg for past 12 years. Symptoms occurred mostly in evenings and nights.
#MedTwitter #neurotwitter
2. She would develop crawling sensation and discomfort in right leg while sitting for long or lying down, which would go away only after she jerked or vigorously shook her leg.
She remained reasonably well during the day.
She remained reasonably well during the day.
3. These symptoms occurred on daily basis causing sleep disturbance (she could #sleep only 5 hours at night).
She felt tired during day and found it hard to concentrate.
She was unable to sit for long while travelling or during meetings during daytime.
She felt tired during day and found it hard to concentrate.
She was unable to sit for long while travelling or during meetings during daytime.
Are there any changes in #brain #structure during the first year following #trauma #exposure? Is there a difference between individuals who develop #chronic #PTSD and those who #recover? A quick thread about our work published today in @molpsychiatry📜🧠🧵
nature.com/articles/s4138…
nature.com/articles/s4138…
Reduced #hippocampus and #amygdala volumes have been repeatedly documented in #PTSD patients. But do they reflect a #pretrauma vulnerability trait or #postexposure stress-induced atrophy?
To answer this question, we examined the association between #longitudinal #volumetric #changes of the hippocampus and the amygdala, as well as their #key #subregions, and #PTSD #symptom #trajectories during the first #14months following #trauma exposure.
🔥Highlight from @BavenoVII #cirrhosis session
CSPH Cut-off:
✅Rule in: LSM>25kPa
✅Rule out: LSM<12kPa, Plt>150
👀co-factors:
⛔️Obesity
⛔️Diabetes
⛔️Alcohol
#ILC2022 #Livertwitter @ReibergerThomas @RodriguesSu24 @crisripol @jaumebosch9 @EASLnews
CSPH Cut-off:
✅Rule in: LSM>25kPa
✅Rule out: LSM<12kPa, Plt>150
👀co-factors:
⛔️Obesity
⛔️Diabetes
⛔️Alcohol
#ILC2022 #Livertwitter @ReibergerThomas @RodriguesSu24 @crisripol @jaumebosch9 @EASLnews
Defining Recompensation @BavenoVII
✅Regression (struc/func)
⛔️Primary etiology
⛔️Decompensation (<12m)
✅Stable Liver func
#ILC2022 #LiverTwitter @ReibergerThomas @RodriguesSu24 @crisripol @MattiasMandorf1 @jaumebosch9 @ggarciatsao
✅Regression (struc/func)
⛔️Primary etiology
⛔️Decompensation (<12m)
✅Stable Liver func
#ILC2022 #LiverTwitter @ReibergerThomas @RodriguesSu24 @crisripol @MattiasMandorf1 @jaumebosch9 @ggarciatsao
🔥PSVD by Dr Aurelie Plessier @ValdigGroup
Based on #clinical/#histo
✅Specific signs
✅Non-specific signs
🗝️Histology essential for diagnosis (nor now)
👉emerging role: NOT in PSVD
#ILC2022 #LiverTwitter @BavenoVII @ggarciatsao @ReibergerThomas @VirginiaHdezGea @jaumebosch9
Based on #clinical/#histo
✅Specific signs
✅Non-specific signs
🗝️Histology essential for diagnosis (nor now)
👉emerging role: NOT in PSVD
#ILC2022 #LiverTwitter @BavenoVII @ggarciatsao @ReibergerThomas @VirginiaHdezGea @jaumebosch9
Pre-dawn, MP is working remotely from the roof-top pool at the hotel, preparing for the session @IUPESMWC2022. He gets text on ‘WhatsApp’ from IM
IM: Hey doc, I see that you are checking the slides one final time. BTW, we all are looking forward to your session this morning
1/
IM: Hey doc, I see that you are checking the slides one final time. BTW, we all are looking forward to your session this morning
1/
MP: Really, how come?
IM: Since #WC2022 is hybrid, even though it is late in some parts, we are looking forward
MP: Thanks–Yes, lot of efforts went in pulling this session. Thanks to Dr Borras (@IOMP & @aapmHQ ) & Dr Tom Judd (@IFBME & @WHO ), even I am looking forward to
2/
IM: Since #WC2022 is hybrid, even though it is late in some parts, we are looking forward
MP: Thanks–Yes, lot of efforts went in pulling this session. Thanks to Dr Borras (@IOMP & @aapmHQ ) & Dr Tom Judd (@IFBME & @WHO ), even I am looking forward to
2/
IM: BTW doc, my cousin said, she liked your title, “Symbiotic relationship between #MedicalPhysicists and #Clinical Engineers” & so do I.
MP: Glad you liked, hopefully y’all will like what I present
@WelcomeSG
3/
MP: Glad you liked, hopefully y’all will like what I present
@WelcomeSG
3/
#Thread #Health #Elders #SeniorCitizens
By Arnaldo Liechtenstein, physician: "Whenever, I teach #clinical #Medicine to students in the fourth year of medicine, I ask the following question:
"What are the causes of mental confusion in the elderly?"
1
By Arnaldo Liechtenstein, physician: "Whenever, I teach #clinical #Medicine to students in the fourth year of medicine, I ask the following question:
"What are the causes of mental confusion in the elderly?"
1
Some answer: "Tumors in the head".
I answer: No!
Others suggest: "Early symptoms of Alzheimer's".
I answer again: No!
With each rejection of their answers, their responses dry up.
And they are even more open-mouthed, when I list the three most common causes:
2
I answer: No!
Others suggest: "Early symptoms of Alzheimer's".
I answer again: No!
With each rejection of their answers, their responses dry up.
And they are even more open-mouthed, when I list the three most common causes:
2
- uncontrolled diabetes
- urinary infection
- dehydration
It may sound like a joke; but it isn't.
People over 60 generally stop feeling thirsty and consequently, stop drinking fluids.
When no one is around to remind them to drink fluids, they quickly dehydrate.
3
- urinary infection
- dehydration
It may sound like a joke; but it isn't.
People over 60 generally stop feeling thirsty and consequently, stop drinking fluids.
When no one is around to remind them to drink fluids, they quickly dehydrate.
3
Victorian biomedical science and innovation come of age. #mRNA #Protein #Vaccine
A somewhat long thread:
Our #mRNA vaccine was conceptualised, invented, developed and manufactured (mostly) right here in #Australia. And has now reached #clinical trials.
heraldsun.com.au/news/victoria/…
A somewhat long thread:
Our #mRNA vaccine was conceptualised, invented, developed and manufactured (mostly) right here in #Australia. And has now reached #clinical trials.
heraldsun.com.au/news/victoria/…
2/ To say the least: It has been a thrilling journey.
All I want is to say a few words about innovating a new class of medicine and mention some of the important people and events related to the #mRNA vaccine.
This is my short and personal tribute to them and the events
All I want is to say a few words about innovating a new class of medicine and mention some of the important people and events related to the #mRNA vaccine.
This is my short and personal tribute to them and the events
To translate a product from bench to clinic in two years is not easy- but to do that with a completely new entity that has never been manufactured or developed in the history of Australia - mRNA vaccines- is even more challenging. But our team was up to the challenge.
1/16 So, a long weekend to reflect on @DHRewired last week. After a couple of dog-walks and marathon poo-picking sessions, plenty of time to think. I keep coming back to the #frontline #digitisation programme. I offer this constructively. If you want to discuss, contact me
2/16 The session with the biggest impact was #Tim #Ferris. He talked about his experience in Boston at Mass Gen and he stressed that once they’d put a single system in across 8 hospitals, all staff were part of one team and they were all on the same page for every patient
3/16 What greatly troubled me is that there was no acknowledgement in the world of ICS where we are driving vertical integration, we cannot be working on a single system
Just a friendly reminder @moderna_tx told the @SECGov that the @US_FDA defines #mRNA as gene therapy. And called it an unprecedented new category of #medicines tho they really want that #vaccine classification anyways for liability protections & fear the public wouldn’t take it.
🔥Off the press: focused review on #race #ethnicity #hypertension #heartdisease w @KcfMd @ycommodore @JACCJournals #healthequity #bloodpressure #HTNroundtable #HTN80 #CardioTwitter #medtwitter @HHSGov @Surgeon_General @HeartNews @ABCardio1 @ACCinTouch
bit.ly/3rTMDG4
bit.ly/3rTMDG4
🩺#hypertension is the leading preventable #riskfactor for #heartdisease & #stroke
🩺#hypertension is a major contributor to #racial & #ethnic #disparities in #cardiovasculardisease
🩺#hypertension rates among #Black adults are one of the highest rates of globally
#HTNroundtable
🩺#hypertension is a major contributor to #racial & #ethnic #disparities in #cardiovasculardisease
🩺#hypertension rates among #Black adults are one of the highest rates of globally
#HTNroundtable
🩺#hypertension #control remains a persistent #clinical problem & #publichealth #challenge
🩺We must eliminate these #disparities in #HTN and address #barriers to #hypertensioncontrol
🩺#HTN80 #HTNroundtable #HealthEquity #bloodpressure #hypertensioncontrol
🩺We must eliminate these #disparities in #HTN and address #barriers to #hypertensioncontrol
🩺#HTN80 #HTNroundtable #HealthEquity #bloodpressure #hypertensioncontrol
1/14 🆕 🚨Accelerated article on #breastcancer just out in @nature! #bcsm
We asked:
1️⃣ What drives response to #chemotherapy in #breast #cancer❓
2️⃣ Can we use #machinelearning to predict response to chemotherapy❓
Link: nature.com/articles/s4158…
A 🧵👇👇👇 @OncoAlert
We asked:
1️⃣ What drives response to #chemotherapy in #breast #cancer❓
2️⃣ Can we use #machinelearning to predict response to chemotherapy❓
Link: nature.com/articles/s4158…
A 🧵👇👇👇 @OncoAlert
2/14 We are unable to #predict #response to treatment in clinic…
✅Good response ➡️treatment very effective ➡️better survival
❌Poorer response ➡️treatment less effective ➡️worse survival
Being able to forecast response would be a landmark advance!
✅Good response ➡️treatment very effective ➡️better survival
❌Poorer response ➡️treatment less effective ➡️worse survival
Being able to forecast response would be a landmark advance!
3/14 We ran a study in women with #breastcancer @CUH_NHS+@CRUK_CI:
1️⃣who had a #cancer biopsy (which we analysed)
2️⃣received 18 weeks of chemo+/-targeted therapy
3️⃣had surgery (and we measured how much cancer remained)
We associated PRE-therapy profiles↔️POST-therapy response👇
1️⃣who had a #cancer biopsy (which we analysed)
2️⃣received 18 weeks of chemo+/-targeted therapy
3️⃣had surgery (and we measured how much cancer remained)
We associated PRE-therapy profiles↔️POST-therapy response👇
1/ Excited to share how T cell therapies kill #leukemia!! multi-omics + new #computational #singlecell tools for longitudinal analysis 👉unexpected answer! cell.com/cell-reports/f…
*👏* @elhamazizi! 🙏 @dpeer Cathy Wu @MDAndersonNews @CPRITTexas @ColumbiaBME @sloan_kettering
*👏* @elhamazizi! 🙏 @dpeer Cathy Wu @MDAndersonNews @CPRITTexas @ColumbiaBME @sloan_kettering
2/ We studied donor lymphocyte infusion (DLI) - an #Immunotherapy for relapsed #leukemia after #BMT & the #og of #celltherapy. Previously, we showed DLI reversed T cell exhaustion - but didn't know why/how/which T cells were responsible...
ashpublications.org/blood/article/…
ashpublications.org/blood/article/…
3/ To address these ?'s, we modeled intraleukemic T cell dynamics by integrating longitudinal, multimodal data from ~100K T cells (!) during response (R) or resistance (NR: nonresponder) to DLI.
This month marks a decade since I completed medical #internship. I thought then that I had achieved my goal, that I would find joy in my work. Little did I know where life would lead me. My #reminisces & #reflections - too long for a tweet & too short for a blog - hence, a 🧵
As the first & only #medical student in the extended family, I was in #unfamiliar waters. Moving to uncle's house in another city was a not-too-comfortable but not-wholly-unpleasant change. I'm privileged to be part of a family who did all they could to keep me happy
The pedagogy was #authoritative & #oppressive; seemed to be designed to #humiliate, not teach. I couldn't learn by rote, didn't know of any better ways (pre- ubiquitous smartphone era) Expected to address #seniors using honorifics, I felt they were as unapproachable as teachers
The Webinar on "Monoclonal gammopathy and its significance for kidneys" is about to begin!
There is still time to test your knowledge by solving the @ISNeducation quiz ➡️ bit.ly/3j7U5cn
There is still time to test your knowledge by solving the @ISNeducation quiz ➡️ bit.ly/3j7U5cn
Starting now!
Webinar: "Monoclonal Gammopathy of Renal Significance - Clinical Perspective" with
@arzuvelix and Serhan Tuglular
#ISNwebinar
Webinar: "Monoclonal Gammopathy of Renal Significance - Clinical Perspective" with
@arzuvelix and Serhan Tuglular
#ISNwebinar
Welcome Dr @arzuvelix and Dr Serhan Tuglular
Webinar: "Monoclonal Gammopathy of Renal Significance -Clinical Perspective" with
#ISNwebinar
Webinar: "Monoclonal Gammopathy of Renal Significance -Clinical Perspective" with
#ISNwebinar
Here's a fun #NINO - the UK's National Insurance Number - [Thread] to start the weekend 👇
Maybe I should do an #NHSnumber one sometime? It's a fascinating story, which (ironically) starts with these...
Maybe I should do an #NHSnumber one sometime? It's a fascinating story, which (ironically) starts with these...
[With thanks to @guy_herbert, @TomSamaki, @PrivacyMatters & others for encouragement!]
Before I start a geeky 'deep dive' on the #NHSnumber, to provide some (personal/professional) context that will hopefully become apparent, I'll just drop these two images here:
Before I start a geeky 'deep dive' on the #NHSnumber, to provide some (personal/professional) context that will hopefully become apparent, I'll just drop these two images here:
So, to begin.
After the Second World War, in a time when we started to think (again) what a #civilised society would be, and when our leaders tried to agree #principles like #UDHR that might prevent the recurrence of genocide, and support #dignity and #HumanRights for all...
After the Second World War, in a time when we started to think (again) what a #civilised society would be, and when our leaders tried to agree #principles like #UDHR that might prevent the recurrence of genocide, and support #dignity and #HumanRights for all...
Further, suboxone has required special training and certification, adding an administrative barrier and creating an added fear barrier among risk-averse clinicians whereas oxycodone can be prescribed easily with the DEA certificate we all have.
Because doctors/prescribers are definitely lacking in administrative burden and CME obligations, we're just twiddling our thumbs eager for someone to ask us to get MORE educated, taking time off from patient care to get this:
medpagetoday.com/psychiatry/add…
medpagetoday.com/psychiatry/add…
The law enforcement side sees doctors through this lens. So doctors seek to limit their risk and liability. I'm all for taking down those who harm patients. I've testified in cases like the ones below for the AG's office as a medical expert.
medscape.com/viewarticle/91…
medscape.com/viewarticle/91…
1
Listen to this story of #tuberculosis
Real, not fiction. Even though may sound like super fiction. Of a patient now admitted under me.
56 yr man. Prior #smoker No #alcohol use, no #DRUGS. Family guy. Starts havin cough. Nagging no sputum
Keeps him awake at night
#MedTwitter
Listen to this story of #tuberculosis
Real, not fiction. Even though may sound like super fiction. Of a patient now admitted under me.
56 yr man. Prior #smoker No #alcohol use, no #DRUGS. Family guy. Starts havin cough. Nagging no sputum
Keeps him awake at night
#MedTwitter
2
He goes 2 a GP. Clinical examination and blood tests done. Says some chest infection. Puts him on antibiotics for a week. Asks for review. 1wk later some change in symptoms, but not fully ok. GP extends antibiotic course 7 more days. C, no fever and no signs of infection yet.
He goes 2 a GP. Clinical examination and blood tests done. Says some chest infection. Puts him on antibiotics for a week. Asks for review. 1wk later some change in symptoms, but not fully ok. GP extends antibiotic course 7 more days. C, no fever and no signs of infection yet.
3
After 14d course, no change. Patient chucks the GP. Goes for a senior GP. Senior GP does clinical exam,blood tests AND chest X ray. X ray comes back as "not looking normal" 🙄 But no diagnosis. So he says. Let's try a short course of #antibiotics AND antifungal. Again 14 days
After 14d course, no change. Patient chucks the GP. Goes for a senior GP. Senior GP does clinical exam,blood tests AND chest X ray. X ray comes back as "not looking normal" 🙄 But no diagnosis. So he says. Let's try a short course of #antibiotics AND antifungal. Again 14 days
My highlights of the @10xGenomics #Xperience2021 event. The list of products keeps growing, I would highlight Chromium Connect as an underappreciated tool to bring the products up another level of throughput. Important as with #NGS, it won't take long to go from n=1 to n=96+.
#CellPlex species-agnostic multiplexing up to 12 samples: not dissimilar to products such as TotalSeq, but baked-in so that it's been tested to work with the rest of the workflow.
Going close to 1M cells, the #ChromiumX brings about 100x fold throughput increase, all marked with 'HT' in the Kits. I'd be interesting to know how the different #BodyAtlas projects embrace this and for what.
@FBI - I have been marked as a target by alt right already - my #GOTV work is what #MarjorieTaylorGreene spreads hate on - citizen rights of minorities. The violence that smashed the skull of #OfficerSicknick on Jan 6 was about effective #votingrights work of @staceyabrams
(Deleted tweets cuz the posted link was wrong - gah. I hate deleting tweets but the meaning totally changed.)
What I threaten is the power differential in #healthcare -by my identity & work - all bullying is about power first & foremost. Yes, I threaten bullies & their sidekicks. I open, expand, include vs paranoia to exclude, block.
Other Muslims like me, shot: dailytarheel.com/article/2020/0…
Other Muslims like me, shot: dailytarheel.com/article/2020/0…
A Thread (🧵)
Let's discuss long-read #sequencing, optical mapping, and the implications of a recent study (linked below).
Please view my disclosures at the end. I've intentionally made this thread more technical as I think it's necessary.
biorxiv.org/content/10.110…
Let's discuss long-read #sequencing, optical mapping, and the implications of a recent study (linked below).
Please view my disclosures at the end. I've intentionally made this thread more technical as I think it's necessary.
biorxiv.org/content/10.110…
First, let's deconstruct the paper's title: "De Novo Assembly of 64 Haplotype-Resolved Human Genomes of Diverse Ancestry and Integrated Analysis of Structural Variation".
De novo (Latin: "Of New") assembly involves sequencing a genome without the help of a reference.
De novo (Latin: "Of New") assembly involves sequencing a genome without the help of a reference.
Assembling a #genome de novo is like solving a jigsaw puzzle without using the picture on the front of the box. You could start with the corners, assemble the edges, and try to fill in the rest using color- or shape-matching methods.
Let me use an analogy.
Let me use an analogy.
@jenbrea Hey! So I'm getting to the point where I could write a long paper about potential overlapping connections b/t #Alzheimer's and #MECFS, but I'll summarize a few top trends in this thread! First, I brainstormed often on topic with the late Rob Moir
@jenbrea 2/ Rob’s research (done w/ Rudy Tanzi + Will Eimer at Harvard) forms the core of a potential ongoing paradigm shift in Alzheimer’s - namely that #amyloid beta may be an antimicrobial peptide that forms in response to pathogens in #brain tissue: pubmed.ncbi.nlm.nih.gov/30001512/
@jenbrea 3/ To better understand that research, read this #interview I did with Rob before he passed away last year from glioblastoma. Key to ME/CFS is his work indicates that amyloid may form in response to herpesviruses like HSV1 in the Alzheimer’s brain: microbeminded.com/2017/12/18/int…
