Discover and read the best of Twitter Threads about #Antiviral
Most recents (24)
You mean like provable #CauseAndEffect?
Like #HCQ a 70-yo drug, that IS #SafeAndEffective being #ConfiscatedAndProhibited from use, a historical first, CAUSED mistrust in our govt's National Health Advisor, Tony Fauci and the EFFECT led to countless unnecessary deaths.
Like #HCQ a 70-yo drug, that IS #SafeAndEffective being #ConfiscatedAndProhibited from use, a historical first, CAUSED mistrust in our govt's National Health Advisor, Tony Fauci and the EFFECT led to countless unnecessary deaths.
Or maybe you mean, our govt classifying information that would save lives but expose the above #CauseAndEffect, forcing a legal FOIA request to expose, he was lying and KNEW that 1. people would dies and 2. it violates US #AntiTrustLaws to knowingly manipulate the market in order
to force the market to have no choice but to use a product you directly profit from?
So the first event; denying 333M Americans #HCQ, which was used successfully to ward off the #ZikaPandemic b/c of its' #AntiInflammatory and #AntiViral abilities for which it won a #NobelPrize
So the first event; denying 333M Americans #HCQ, which was used successfully to ward off the #ZikaPandemic b/c of its' #AntiInflammatory and #AntiViral abilities for which it won a #NobelPrize
The classic #trilemma goes: "Fast, cheap or good, pick any two." The #ModeratorsTrilemma goes, "Large, diverse userbase; centralized platforms; don't anger users - pick any two." 1/
If you'd like an essay-formatted version of this thread to read or share, here's a link to it on pluralistic.net, my surveillance-free, ad-free, tracker-free blog:
pluralistic.net/2023/03/04/pic… 2/
pluralistic.net/2023/03/04/pic… 2/
The Moderator's Trilemma is introduced in "Moderating the Fediverse: Content Moderation on Distributed Social Media," a superb paper from @ARozenshtein of @UofMNLawSchool, forthcoming in the journal @JournalSpeech, available as a prepub on @SSRN:
papers.ssrn.com/sol3/papers.cf… 3/
papers.ssrn.com/sol3/papers.cf… 3/
Let's talk about #H5N1 ! What is the risk for us humans and should we be worried?
Also at virology blog. 1/
virology.ws/2023/03/02/its…
Also at virology blog. 1/
virology.ws/2023/03/02/its…
Recent news headlines have been highlighting the global spread of #H5N1, the strain of influenza virus that is typically associated with “bird flu.” 2/
This outbreak is the largest in recorded history, involving at least 50 million dead birds and countless non-human mammals, including sea lions, otters, mink, foxes, cats, dogs, and skunks. But what does this mean for us? 3/
#Riboflavin (#vitamin B2) versus #covid19?
A series of molecular docking studies (modeling of biological actions by computer) indicate that plain old cheap old perfectly-safe old RIBOFLAVIN inhibits critical #SARS_CoV2 #proteases -- thus acting as potential #antiviral compound.
A series of molecular docking studies (modeling of biological actions by computer) indicate that plain old cheap old perfectly-safe old RIBOFLAVIN inhibits critical #SARS_CoV2 #proteases -- thus acting as potential #antiviral compound.
By analogy: viral protease inhibitors are the basis of anti-#HIV #ART (anti-retroviral therapy) - drugs used widely to maintain disease-free, #AIDS-free life, albeit at a cost: $25-50K per year. Plus headache, nausea, diarrhea, fatigue, and a dozen other crappy side effects.
Riboflavin, if it proves to be effective in humans, or even if it doesn't, would cost perhaps $25 (twenty five, not 25 thousand) per year, with no headaches, nausea or the rest of that rot. Just so you know.
There is only slight chance that the definitive human studies will be
There is only slight chance that the definitive human studies will be
#Prayagraj व देश में #dengue के बढ़ते केस व #platelets के लिए मचे हाहाकार के कारण मैं ये पोस्ट पुनः लिख रहा हूँ!
घर पर बन सकने वाला ये #Ayurveda #काढ़ा #प्लेट्लेट्स संख्या कम होने से सफलतापूर्वक रोकता है, ऐसा मेरा 12 वर्षों का अनुभव है!
कृपया शेयर कर लोगों की सहायता करें!
1/n
घर पर बन सकने वाला ये #Ayurveda #काढ़ा #प्लेट्लेट्स संख्या कम होने से सफलतापूर्वक रोकता है, ऐसा मेरा 12 वर्षों का अनुभव है!
कृपया शेयर कर लोगों की सहायता करें!
1/n
2/n
हर साल ये काढ़ा मैं हज़ारों मरीज़ों को देता रहा हूँ, लेकिन फिर भी असंख्य मरीज़ों को ये काढ़ा मैं नहीं दे पाता हूँ,
इसलिए इस काढ़े को #घर_पर_बनाने_का_तरीक़ा मैं फिर से शेयर कर रहा हूँ, ताकि आप इसे घर पर भी भविष्य की ज़रूरत के लिए बना कर रख सकें!
हर साल ये काढ़ा मैं हज़ारों मरीज़ों को देता रहा हूँ, लेकिन फिर भी असंख्य मरीज़ों को ये काढ़ा मैं नहीं दे पाता हूँ,
इसलिए इस काढ़े को #घर_पर_बनाने_का_तरीक़ा मैं फिर से शेयर कर रहा हूँ, ताकि आप इसे घर पर भी भविष्य की ज़रूरत के लिए बना कर रख सकें!
3/n
STEP_1
1 लीटर काढ़ा बनाने में मात्र लगभग ₹3000/ का खर्च आता है (अगर जड़ी बूटियाँ ठीक मिल जाएँ तो), और इतना काढ़ा #Dengue के 2 रोगियों के लिए पर्याप्त है!
निम्नलिखित सूखी हुयी जड़ी-बूटियों को बराबर मात्रा में लीजिएः
1. अतिविषा
2. द्रोणपुष्पी
3. वासा
4. हरीतकी..
STEP_1
1 लीटर काढ़ा बनाने में मात्र लगभग ₹3000/ का खर्च आता है (अगर जड़ी बूटियाँ ठीक मिल जाएँ तो), और इतना काढ़ा #Dengue के 2 रोगियों के लिए पर्याप्त है!
निम्नलिखित सूखी हुयी जड़ी-बूटियों को बराबर मात्रा में लीजिएः
1. अतिविषा
2. द्रोणपुष्पी
3. वासा
4. हरीतकी..
Hier le médecin à l'hopital ne percutait pas sur le #paxlovid. Aujourd'hui ils ont eu une réunion de service & il va regarder. Des interactions médicamenteuses & des contre-indications, mais j'espère que cela va le faire.
#Antiviral sur #ordonnance
#covid19
1/10
#Antiviral sur #ordonnance
#covid19
1/10
2/10
Au cas où je m'étais bien documentée et je mets les liens dans ce thread.
C'est à prendre dans les 5 jours, et même si les molécules ne sont pas nouvelles mais l'usage associé l'est donc il est intéressant d'être bien au courant avec son médecin.
Au cas où je m'étais bien documentée et je mets les liens dans ce thread.
C'est à prendre dans les 5 jours, et même si les molécules ne sont pas nouvelles mais l'usage associé l'est donc il est intéressant d'être bien au courant avec son médecin.
3/10
#Paxlovid (PF-07321332/ritonavir) #France #EU #UE
Aperçu de Paxlovid et pourquoi il est autorisé dans l’Union européenne (UE)
European Medicines Agency
ema.europa.eu/en/documents/o…
#Paxlovid (PF-07321332/ritonavir) #France #EU #UE
Aperçu de Paxlovid et pourquoi il est autorisé dans l’Union européenne (UE)
European Medicines Agency
ema.europa.eu/en/documents/o…
Multi-country #monkeypox #outbreak: situation update
780 laboratory confirmed cases of monkeypox have been reported to or identified by #WHO from 27 Member States across four WHO regions that are not endemic for monkeypox virus.
1/9
who.int/emergencies/di…
780 laboratory confirmed cases of monkeypox have been reported to or identified by #WHO from 27 Member States across four WHO regions that are not endemic for monkeypox virus.
1/9
who.int/emergencies/di…
#Monkeypox outbreaks in endemic countries in the #African región, 2022.
1408 suspected and 44 confirmed cases including 66 deaths were reported from seven endemic countries
2/9
1408 suspected and 44 confirmed cases including 66 deaths were reported from seven endemic countries
2/9
WHO #Risk assessment: MODERATE considering this is the first time that many #monkeypox cases and clusters are reported concurrently in non-endemic and endemic countries in widely disparate WHO geographical areas.
3/9
3/9
La gente en #Venezuela anda comprando #Molnupiravir y #Remdesivir como si fuera Acetaminofen. Muchas veces sin prescripción médica, solo porque el familiar, el amigo o la vecina se lo recomendo.
Aquí les explico cuál es su uso correcto
🧵
Aquí les explico cuál es su uso correcto
🧵
Tenemos 4 #antivirales disponibles para #COVID19 hasta el momento.
#Paxlovid (Nirmatrelvir/Ritonavir) (oral)
#Sotrovimab (endovenoso)
#Remdesivir (endovenoso)
#Molnupiravir (oral)
De las cuáles, solo tenemos disponibles en Venezuela los 2 últimos.
#Paxlovid (Nirmatrelvir/Ritonavir) (oral)
#Sotrovimab (endovenoso)
#Remdesivir (endovenoso)
#Molnupiravir (oral)
De las cuáles, solo tenemos disponibles en Venezuela los 2 últimos.
¿Cuando usarlos?
Se recomienda el uso de #antivirales orales en pacientes NO hospitalizados con enfermedad leve/moderada (Saturación mayor o igual a 94%) que tienen ALTO RIESGO DE PROGRESIÓN.
Ese riesgo será definido por su médico, pero les voy a aclarar a que se refiere eso.
Se recomienda el uso de #antivirales orales en pacientes NO hospitalizados con enfermedad leve/moderada (Saturación mayor o igual a 94%) que tienen ALTO RIESGO DE PROGRESIÓN.
Ese riesgo será definido por su médico, pero les voy a aclarar a que se refiere eso.
Happy to be a co-author of this article about #viralepersistence in #longCovid patients-found by dogs of @Env_Alfort- w/ Dominique GRANDJEAN, Dorsaf SLAMA, Capucine GALLET, Clothilde JULIEN, Marc BLONDOT, Maissa BENAZAZIEZ, Judith ELBAZ and Dominique SALMON #apresJ20 #Covid19
Dogs have already demonstrated high capacity in detecting Covid19 infection in acute phase (very high sensitivity)
Now they help demonstrating once more that #viralepersistence is present « in some Long Covid patient »..#apresJ20 #longCovid #Covidlong #Covid19 👇
Now they help demonstrating once more that #viralepersistence is present « in some Long Covid patient »..#apresJ20 #longCovid #Covidlong #Covid19 👇
I would like to explain why we wrote « at least in some Long Covid patients » : dogs positively discriminated half of the 45 people but there are surely much more #longCovid #Covidlong positive = with #viralepersistence #persistancevirale #apresJ20 👇
Antiviral pills for #COVID19 may be available soon: 3 in clinical trials, results expected as soon as late fall/winter: Merck & Ridgeback Biotherapeutics’ #molnupiravir ; Pfizer’s #PF07321332, & Roche & Atea’s #AT527 usatoday.com/story/news/hea…
“only one antiviral drug, remdesivir, has been approved to treat #COVID. But it is given intravenously to patients ill enough to be hospitalized, & is not intended for early, widespread use. By contrast, the top contenders under study can be packaged as pills.”
“That would mean millions …could have access to a daily orally administered medication, ideally a single pill, that could be taken for five to 10 days at the first confirmation of #COVID19 infection”
#location location location: thrilled to share our work @CellCellPress! #interferons dictate #COVID19 severity! Specific #IFNs are produced along the #airways in response to #SARSCoV2 and drive protective or detrimental #transcriptional programs! 1/7 doi.org/10.1016/j.cell…
The #COVID19 #antiviral domain within @remap_cap has been updated and is already recruiting! Twenty-seven patients have already been randomized.
The objective of this domain is to determine the effectiveness of different #antiviral agents for #COVID19 patients.
This @remap_cap domain previously compared hydroxychloroquine, lopinavir-ritonavir, and a combination of these agents against a Standard of Care control.
link.springer.com/article/10.100…
link.springer.com/article/10.100…
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
1/
Ministry of #AYUSH new task force 2 study effects of Ashwagandha+Yashtimadhu+Guduchi+Pippali+poly herbal drug (AYUSH-64) #Covid_19
Link: bit.ly/38xe9Pc
Decision coms aftr prev imaginary but negative trials on Ashwagandha+Guduchi+Chyawanprash
More than meets the eye+
Ministry of #AYUSH new task force 2 study effects of Ashwagandha+Yashtimadhu+Guduchi+Pippali+poly herbal drug (AYUSH-64) #Covid_19
Link: bit.ly/38xe9Pc
Decision coms aftr prev imaginary but negative trials on Ashwagandha+Guduchi+Chyawanprash
More than meets the eye+
2/
This time the ministry is DAMN sure this combination will work - bcoz they hav included their 'trump' card in the treatment combination - AYUSH-64
Know more about this super *cough* drug
Made in 1980 (Yes, older than me)
First released in 2000 4 malaria (yes, anti-parasite)
This time the ministry is DAMN sure this combination will work - bcoz they hav included their 'trump' card in the treatment combination - AYUSH-64
Know more about this super *cough* drug
Made in 1980 (Yes, older than me)
First released in 2000 4 malaria (yes, anti-parasite)
3/
Sadly, peer-reviewed paper in Current Science
showed it was not good, inferior 2 chloroquine
2016 - licensed 2 #Dabur as anti-malarial - failed 2 gain momentum
In between did an item-number dance as anti-filarial
Movie flopped
Thereafter, every1 forgot abt AYUSH-64😭
But,
Sadly, peer-reviewed paper in Current Science
showed it was not good, inferior 2 chloroquine
2016 - licensed 2 #Dabur as anti-malarial - failed 2 gain momentum
In between did an item-number dance as anti-filarial
Movie flopped
Thereafter, every1 forgot abt AYUSH-64😭
But,
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
31/08 > Un #antiviral utilisé pour traiter le #coronavirus félin se montre également efficace contre le #SARSCoV2 bit.ly/31NvnVH via @TrustMyScience #LaMethSci
[L’étude à découvrir] 27/08 > Le médicament contre le #coronavirus félin inhibe la principale protéase du #SARSCoV2 et bloque la réplication du #virus go.nature.com/3gNb4fk via @NatureComms #LaMethSci
Tabulated the topline results released by the #recoverytrial team on #hydroxychloroquine & #dexamethasone, and went over their protocol (recoverytrial.net/results) to better digest them.
Basic stuff:
- hospitalized patients @ 175 NHS centres
- open label, 5 initial arms
- thread—
Basic stuff:
- hospitalized patients @ 175 NHS centres
- open label, 5 initial arms
- thread—
Important point from #RECOVERYTrial protocol
- if a patient had a #contraindication to one of the intervention arms, according to the clinical care team at the site, that particular arm was not available to that patient at the time of #randomization
- if a patient had a #contraindication to one of the intervention arms, according to the clinical care team at the site, that particular arm was not available to that patient at the time of #randomization
So if a patient enrolled in #recoverytrial had a contraindication to #dexamethasone, that patient was not allowed to be randomized to that arm. So the results need to be interpreted in the context of no contraindication to steroids: already on steroids, #immunosuppression, etc.
Clearly the conclusion is biased because there is no significant reduction in mortality showing it is ineffective in serious cases who actually need treatment. As a clinical #Pharmacologist my conclusion is: #Remdesivir should not be standard of care for any patient of #COVID19
The mortality rate as stated reduced from 11% to 8% (3%) that they admit insignificant despite being "highly powered multicenter randomised controlled trial (RCT)".This is the clue to understand that they are trying to make this expensive drug as standard of care. #Remdesivir
The preoccupation to prove efficacy of so called modern synthetic drugs with patents is so heavy for obvious reasons that it is almost impossible to "prove" the efficacy of traditionally used antiviral formulations or herbs despite having so much in vitro as well as vivo evidence
Starting a series on clinical Pearls I am gathering in #COVID19 patients based on experiences of many experts
Will add as we go along
Feel free to add your own observations/experiences
#covidclinicalpearls /1
Will add as we go along
Feel free to add your own observations/experiences
#covidclinicalpearls /1
Anosmia is likely the most specific #COVID19 related symptom
30% of patients have anosmia as their 1st symptom
#covidclinicalpearls /2
30% of patients have anosmia as their 1st symptom
#covidclinicalpearls /2
Around 90% of patients have fever.
50% maybe afebrile at the time of presentation
Fever tends to be very resistant to routine measures in hospitalized patients
There is no consensus that NSAIDs are to be avoided in #COVID2019 patients
#covidclinicalpearls /3
50% maybe afebrile at the time of presentation
Fever tends to be very resistant to routine measures in hospitalized patients
There is no consensus that NSAIDs are to be avoided in #COVID2019 patients
#covidclinicalpearls /3
Follow this thread for coverage of our SFI Flash Workshop re: #COVID19, "After the First Wave," organized by @mikha_ehl, Cris Moore, & @svscarpino — with presentations by @meyerslab, @Caroline_OF_B, @rajivatbarnard, @glenweyl, & @sdelvall.
More info:
santafe.edu/events/after-f…
More info:
santafe.edu/events/after-f…
Some background from Lauren Ancel Meyers @meyerslab about the #epidemiology modeling community's efforts to produce #pandemic projections for the @CDC — first about #influenza and then, suddenly and with the models incomplete, pivoting to #COVID19:
Aggregate data from travel in and out of #Wuhan in early 2020. To infer the pace of the #epidemic, @meyerslab and colleagues used info on timing & location from first cases in other areas, travel volume to/from Wuhan, and gave an early doubling rate for #COVID19:
As the elderly are more susceptible to #COVID19 w/ signs of lung #inflammation, here's a thread about our @virusesimmunity 2016 flu paper on #antiviral resistance, excessive lung #inflammation, & a strategy to boost disease tolerance! science.sciencemag.org/content/352/62…
First we demonstrated that monos & macs from older adults have impaired type I IFN (antiviral) & #ISG responses but intact cytokine responses after #flu infection. To probe the possible in vivo consequences of weak #IFN responses in the face of robust inflammation...
... we made a mouse model that mimicked this immune response in the elderly (Mx1+/+ mice w/ genetic deletion of tlr7, mavs). Failure to induce type I IFN led to high viral titer, 2º bacterial infection, severe lung inflammation, and death.
With the #COVID19 outbreak, it is important to use language responsibly. Here is the first entry of our new #ContagiousWords series, defining the buzzwords and terminology dominating today's conversation. #Pandemic #PandemicsCost
@ilariacapua Language is powerful, so we must be sure and accurate in the ways we communicate science. #Epidemic #ContagiousWords #COVID19
